Professor Geoff Targett DSc PhD BSc

Emeritus Professor of Immunology of Parasitic Diseases

• Affiliation
• Teaching
• Research
• Publications

• 
• Room 406
• LSHTM
• Keppel Street
• London
• WC1E 7HT
• T: 44 (0)20 7299 4708
• F: 44(0)20 7299 4720

Geoffrey Targett is a graduate in Zoology from Nottingham and began his research career with the UK Medical Research Council first at the Bilharzia Research Unit, then the National Institute for Medical Research. He was a lecturer at the University of St. Andrews, Scotland for six years before joining LSHTM. His research has covered a range of parasitic infections but has concentrated mainly on malaria immunology, chemotherapy and transmission. He was head of the Department of Medical Parasitology for nine years until 1997 and Acting Dean of the School in 2000. From 2000-2008 he was Deputy Director of the Gates Malaria Partnership, and now provides support in major capacity development and international research partnership initiatives.

Affiliation

• Immunology and Infection Department
• Department of Disease Control

Teaching

My main teaching is on malaria for several of the MSc courses and the DTM&H, covering variously parasite biology, immunology and vaccines, pathogenesis and epidemiology.

Research

My major research interest for a long time has been to investigate experimentally and in clinical trials ways in which transmission of malaria can be interrupted, thus providing a means of protecting the population as a whole. This has included studies on the natural and artificial induction of transmission-blocking immunity and  on the use of different drug combinations that, as well as being therapeutic, may stop transmission and, concurrently, slow the spread of drug resistant parasites. In my role as Deputy Director of the Gates Malaria Partership I was involved in an extensive programme of applied malaria research in Africa concerned with evaluation of antimalarial drug combinations , new vector control measures, malaria vaccines, and management of malaria at community, household and individual level.This provides a good baseline for substantial current involvement in development of malaria elimination strategies, in particular through the Malaria Elimination Group (MEG) and WHO.

• Selected publications

• Human immune responses that reduce the transmission of Plasmodium falciparum in African populations.

  Bousema, T.; Sutherland, C.J.; Churcher, T.S.; Mulder, B.; Gouagna, L.C.; Riley, E.M.; Targett, G.A.; Drakeley, C.J.;

  Int J Parasitol, 2010;

• Operational strategies to achieve and maintain malaria elimination.

  Moonen, B.; Cohen, J.M.; Snow, R.W.; Slutsker, L.; Drakeley, C.; Smith, D.L.; Abeyasinghe, R.R.; Rodriguez, M.H.; Maharaj, R.; Tanner, M.; Targett, G.;

  Lancet, 2010; 376(9752):1592-603

• The Dynamics of Naturally Acquired Immune Responses to Plasmodium falciparum Sexual Stage Antigens Pfs230 & Pfs48/45 in a Low Endemic Area in Tanzania.

  Bousema, T.; Roeffen, W.; Meijerink, H.; Mwerinde, H.; Mwakalinga, S.; van Gemert, G.J.; van de Vegte-Bolmer, M.; Mosha, F.; Targett, G.; Riley, E.M.; Sauerwein, R.; Drakeley, C.;

  PLoS One, 2010; 5(11):e14114

• Plasmodium falciparum antigens on the surface of the gametocyte-infected erythrocyte.

  Saeed, M.; Roeffen, W.; Alexander, N.; Drakeley, C.J.; Targett, G.A.; Sutherland, C.J.;

  PLoS ONE, 2008; 3(5):e2280

• Seasonal intermittent preventive treatment with artesunate and sulfadoxine-pyrimethamine for prevention of malaria in Senegalese children: a randomised, placebo-controlled, double-blind trial.

  Cissé, B.; Sokhna, C.; Boulanger, D.; Milet, J.; Bâ, el H.; Richardson, K.; Hallett, R.; Sutherland, C.; Simondon, K.; Simondon, F.; Alexander, N.; Gaye, O.; Targett, G.; Lines, J.; Greenwood, B.; Trape, J.F.;

  Lancet, 2006; 367(9511):659-67

• The epidemiology of Plasmodium falciparum gametocytes: weapons of mass dispersion.

  Drakeley, C.; Sutherland, C.; Bousema, J.T.; Sauerwein, R.W.; Targett, G.A.;

  Trends Parasitol, 2006; 22(9):424-30

• Reduction of Malaria Transmission to Anopheles Mosquitoes with a Six-Dose Regimen of Co-Artemether.

  Sutherland, C.J.; Ord, R.; Dunyo, S.; Jawara, M.; Drakeley, C.J.; Alexander, N.; Coleman, R.; Pinder, M.; Walraven, G.; Targett, G.A.;

  PLoS Med, 2005; 2(4):e92

• Artesunate reduces but does not prevent posttreatment transmission of Plasmodium falciparum to Anopheles gambiae

  Targett, G.; Drakeley, C.; Jawara, M.; von Seidlein, L.; Coleman, R.; Deen, J.; Pinder, M.; Doherty, T.; Sutherland, C.; Walraven, G.; Milligan, P.

  Journal of Infectious Diseases, 2001; 183(8):1254-9

• → View all Professor Geoff Targett's publications

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