Dr Richard Stabler PhD
- Room 380
- LSHTM
- Keppel Street
- London
- WC1E 7HT
- T: 44 207 927 2824
- F: 44 207 637 4314
Work History
I undertook my Ph.D. while working as a research assistant at St Bartholomews Hospital and then LSHTM. After completing the Ph.D. I took a post-doc position at the Bacterial Microarray Group at St. Georges Hospital (BuG@S). I was involved in design, construction, experimental design, application and data analysis on several bacterial projects.
I returned to LSHTM for my second Ph.D position that was primarily to design a microarray that could be used to monitor gene flux of virulence factors.
The Active Surveillance of Pathogens (ASP) microarray has been successfully produced and has been used to identify novel virulence determinants in Shigella sonnei and Chromobacterium violaceum.
Affiliation
Teaching
Lecturer on the MSc Medicial Microbiology course
Lecturer on the MSc Control of Infectious Diseases
Module Organiser on the Distance Learning programme
Research
RCUK Academic fellow
Research interests include
i) Clostridium difficile: molecular epidemiology and emergence of hypervirulent isolates.ii) Listeria monocytogenes: genetic basis of persistant isolates and contamination & transmission within food production facilities.
iii) Campylobacter jejuni: molecular epidemiology and identification of source specific markers.
iv) Development of a Active Surveillance Microarray for Human Pathogens (ASP) to monitor genetic flux.
v) Escherichia coli K1: Analysis of interaction with and role of gut flora in disease process.
vi) Streptococcus pneumoniae: molecular epidemiology of East African isolates
Research areas
- Bacteria
- Diagnostics
- Diarrhoeal diseases
- Genetic epidemiology
- Genomics
- Infectious disease
- Molecular epidemiology
Disciplines
- Bacteriology
- Genetics
- Microbiology
- Molecular biology
- Pathology
Other interests
- Bacterial Biofilms
- Bacterial Infections
- Bayesian Analysis
- Biofilms
- Campylobacter
- Campylobacter Jejuni
- Clostridium Difficile
- Evolution
- Microarray Technology
- Microarrays
- Microbial Pathogenicity
- Pathogenicity
- Pneumococcal Disease
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Selected publications
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Evolutionary dynamics of Clostridium difficile over short and long time scales.
He, M.; Sebaihia, M.; Lawley, T.D.; Stabler, R.A.; Dawson, L.F.; Martin, M.J.; Holt, K.E.; Seth-Smith, H.M.; Quail, M.A.; Rance, R.; Brooks, K.; Churcher, C.; Harris, D.; Bentley, S.D.; Burrows, C.; Clark, L.; Corton, C.; Murray, V.; Rose, G.; Thurston, S.; van Tonder, A.; Walker, D.; Wren, B.W.; Dougan, G.; Parkhill, J.;
Proc Natl Acad Sci U S A, 2010; 107(16):7527-32
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Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium.
Stabler, R.A.; He, M.; Dawson, L.; Martin, M.; Valiente, E.; Corton, C.; Lawley, T.D.; Sebaihia, M.; Quail, M.A.; Rose, G.; Gerding, D.N.; Gibert, M.; Popoff, M.R.; Parkhill, J.; Dougan, G.; Wren, B.W.;
Genome Biol, 2009; 10(9):R102
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Comparative analysis of BI/NAP1/027 hypervirulent strains reveals novel toxin B-encoding gene (tcdB) sequences.
Stabler, R.A.; Dawson, L.F.; Phua, L.T.; Wren, B.W.;
J Med Microbiol, 2008; 57(Pt 6):771-5
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Development and application of the active surveillance of pathogens microarray to monitor bacterial gene flux.
Stabler, R.A.; Dawson, L.F.; Oyston, P.C.; Titball, R.W.; Wade, J.; Hinds, J.; Witney, A.A.; Wren, B.W.;
BMC Microbiol, 2008; 8:177
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The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome
Sebaihia, M.; Wren, B. W.; Mullany, P.; Fairweather, N. F.; Minton, N.; Stabler, R.; Thomson, N. R.; Roberts, A. P.; Cerdeno-Tarrraga, A. M.; Wang, H. W.; Holden, M. T. G.; Wright, A.; Churcher, C.; Quail, M. A.; Baker, S.; Bason, N.; Brooks, K.; Chillingworth, T.; Cronin, A.; Davis, P.; Dowd, L.; Fraser, A.; Feltwell, T.; Hance, Z.; Holroyd, S.; Jagels, K.; Moule, S.; Mungall, K.; Price, C.; Rabbinowitsch, E.; Sharp, S.; Simmonds, M.; Stevens, K.; Unwin, L.; Whithead, S.; Dupuy, B.; Dougan, G.; Barrell, B.; Parkhill, J.
Nature Genetics, 2006; 38(7):779-786
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Comparative Phylogenomics of Clostridium difficile Reveals Clade Specificity and Microevolution of Hypervirulent Strains.
Stabler, R.A.; Gerding, D.N.; Songer, J.G.; Drudy, D.; Brazier, J.S.; Trinh, H.T.; Witney, A.A.; Hinds, J.; Wren, B.W.;
J Bacteriol, 2006; 188(20):7297-305
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Identification of pathogen-specific genes through microarray analysis of pathogenic and commensal Neisseria species.
Stabler, R.A.; Marsden, G.L.; Witney, A.A.; Li, Y.; Bentley, S.D.; Tang, C.M.; Hinds, J.;
Microbiology, 2005; 151(Pt 9):2907-22
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Construction of a Yersinia pestis microarray
Stabler, R.A.; Hinds, J.; Witney, A.A.; Isherwood, K.; Oyston, P.; Titball, R.; Wren, B.W.; Hinchcliffe, S.; Prentice, M.; Mangan, J.A.; Butcher, P.D.
Advances in Experimental Medicine and Biology, 2003; 529:47-51
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