Dr Steven Smith BSc PhD
- Room 236b
- LSHTM
- Keppel Street
- London
- WC1E 7HT
- T: 020 7612 7833
- F: 020 7637 4314
Steven's first degree was a BSc in Medical Sciences from Leeds University. He stayed in Leeds to do a PhD in the area of cancer immunotherapy, developing a DNA vaccine encoding tumour-associated epitopes. His first post-doctoral position was at the Edward Jenner Institute, Berkshire, looking at autoimmunity and T-cell regulation in the context of joint inflammation.
Affiliation
Teaching
Steven's main teaching roles at LSHTM are as organiser for the Principles of Biology module of the MSc Infectious Disease distance learning programme and as a tutor for the immunology section of the same module. He also helps organise and supervise a series of practical classes for the "in house" MSc in Immunology of Infectious Diseases and usually runs one or two lectures and teaching sessions a year associated with these classes.
Research
Steven is currently part of Prof Hazel Dockrell's team, looking at immune responses to BCG vaccination. Although BCG is known to protect infants from childhood forms of tuberculosis, the mechanisms of immunity are unclear. He is particularly interested in the T-cell response to vaccination. Characteristics of this response (e.g. the magnitude, phenotype and antigen specificity) may act as a biomarker of protection following BCG vaccination. Identifying such biomarkers, as well as aiding our understanding of BCG, will also facilitate the development of newer, state of the art vaccines for tuberculosis.
Research areas
- T-cell immunology
- Vaccines
Disciplines
- Immunology
Disease and Health Conditions
- Infectious disease
- Tuberculosis
Other interests
- BCG Vaccination
- CD8 T Cells
- Cellular Immunology
- Flow Cytometry
- Immunization,Vaccine
- Multiplex Assays
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Selected publications
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Mycobacterium tuberculosis PPD-induced immune biomarkers measurable in vitro following BCG vaccination of UK adolescents by multiplex bead array and intracellular cytokine staining.
Smith, S.G.; Lalor, M.K.; Gorak-Stolinska, P.; Blitz, R.; Beveridge, N.E.; Worth, A.; McShane, H.; Dockrell, H.M.;
BMC Immunol, 2010; 11(1):35
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Complex cytokine profiles induced by BCG vaccination in UK infants.
Lalor, M.K.; Smith, S.G.; Floyd, S.; Gorak-Stolinska, P.; Weir, R.E.; Blitz, R.; Branson, K.; Fine, P.E.; Dockrell, H.M.;
Vaccine, 2009; 28(6):1635-41
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Identification of major factors influencing ELISpot-based monitoring of cellular responses to antigens from Mycobacterium tuberculosis.
Smith, S.G.; Joosten, S.A.; Verscheure, V.; Pathan, A.A.; McShane, H.; Ottenhoff, T.H.; Dockrell, H.M.; Mascart, F.;
PLoS One, 2009; 4(11):e7972
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Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following BCG vaccination.
Lin, M.Y.; Geluk, A.; Smith, S.G.; Stewart, A.L.; Friggen, A.H.; Franken, K.L.; Verduyn, M.C.; van Meijgaarden, K.E.; I Voskuil, M.; Dockrell, H.M.; Huygen, K.; Ottenhoff, T.H.; Klein, M.R.;
Infect Immun, 2007; 75(7):3523-30
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A polyepitope DNA vaccine targeted to Her-2/ErbB-2 elicits a broad range of human and murine CTL effectors to protect against tumor challenge.
Scardino, A.; Alimandi, M.; Correale, P.; Smith, S.G.; Bei, R.; Firat, H.; Cusi, M.G.; Faure, O.; Graf-Dubois, S.; Cencioni, G.; Marrocco, J.; Chouaib, S.; Lemonnier, F.A.; Jackson, A.M.; Kosmatopoulos, K.;
Cancer Res, 2007; 67(14):7028-36
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The response of human dendritic cells to recombinant adenovirus, recombinant Mycobacterium bovis Bacillus Calmette Guerin and biolistic methods of antigen delivery: different induction of contact-dependant and soluble signals.
Smith, S.G.; Patel, P.M.; Selby, P.J.; Jackson, A.M.;
Immunol Lett, 2001; 76(2):79-88
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Human dendritic cells genetically engineered to express a melanoma polyepitope DNA vaccine induce multiple cytotoxic T-cell responses.
Smith, S.G.; Patel, P.M.; Porte, J.; Selby, P.J.; Jackson, A.M.;
Clin Cancer Res, 2001; 7(12):4253-61
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