Professor Isabel Silva MD MSc PhD

Professor of Epidemiology

• Affiliation
• Teaching
• Research
• Research areas
• Disciplines
• Publications

• 
• Room 258c
• LSHTM
• Keppel Street
• London
• WC1E 7HT
• T: +44(0)20 7927 2113
• F: +44(0)20 7580 6897

After completing my medical degree in Lisbon (Portugal), I joined the School in 1989 to work on several cancer-related projects.

Affiliation

• Department of Non-communicable Disease Epidemiology

Teaching

I teach in a large number of in-house MSc courses including the MSc Epidemiology. I was co-responsible for the development of teaching material for a large number of study units of the distance learning MSc course "Epidemiology: Principles and Practice". I have organised and taught in a large number of courses overseas including various international courses on cancer epidemiology organised by the International Agency for Research on Cancer (IARC). I wrote a textbook on cancer epidemiology which has been translated into French and Spanish. I have also supervised several PhD students.

Research

Most of our current research includes studies on the pre-natal and early-life origins of breast cancer; various prospective studies on endogenous levels of female sex hormones and growth factors and their relation to mammographic density and subsequent risk of breast cancer; association studies aimed at identifying new low-penetrance breast cancer susceptibility alleles; studies on the health effects of exposure to ionising and non-ionising radiation; and large-population-based cohort studies on human papillomavirus (HPV) and risk of cervical cancer. In collaboration with colleagues at the University of Porto, we have set up a large family-based birth cohort in the north of Portugal.

• Selected publications

• Premenopausal mammographic density in relation to cyclic variations in endogenous sex hormone levels, prolactin, and insulin-like growth factors.

  Walker, K.; Fletcher, O.; Johnson, N.; Coupland, B.; McCormack, V.A.; Folkerd, E.; Gibson, L.; Hillier, S.G.; Holly, J.M.; Moss, S.; Dowsett, M.; Peto, J.; dos Santos Silva, I.;

  Cancer Res, 2009; 69(16):6490-9

• Breast Density and Parenchymal Patterns as Markers of Breast Cancer Risk: A Meta-analysis.

  McCormack, V.A.; dos Santos Silva, I.;

  Cancer Epidemiol Biomarkers Prev, 2006; 15(6):1159-69

• Inconsistent association between the STK15 f31I genetic polymorphism and breast cancer risk

  Fletcher, O.; Johnson, N.; Palles, C.; Dos Santos Silva, I.; McCormack, V.; Whittaker, J.; Ashworth, A.; Peto, J.

  Journal of the National Cancer Institute, 2006; 98(14):1014-1018

• Lack of evidence on diets for obesity for children: a systematic review.

  Gibson, L.J.; Peto, J.; Warren, J.M.; Dos Santos Silva, I;

  Int J Epidemiol, 2006; 35(6):1544-52

• Interaction between CHEK2*1100delC and other low-penetrance breast-cancer susceptibility genes: a familial study

  Johnson, N.; Fletcher, O.; Naceur-Lombardelli, C.; Dos Santos Silva, I. D.; Ashworth, A.; Peto, J.

  Lancet, 2005; 366(9496):1554-7

• Childhood growth and breast cancer

  de Stavola, B. L.; Dos Santos Silva, I.; McCormack, V.; Hardy, R. J.; Kuh, D. J.; Wadsworth, M. E.

  American Journal of Epidemiology, 2004; 159(7):671-82

• Fetal growth and subsequent risk of breast cancer: results from long term follow up of Swedish cohort

  McCormack, V. A.; Dos Santos Silva, I.; de Stavola, B. L.; Mohsen, R.; Leon, D. A.; Lithell, H. O.

  British Medical Journal, 2003; 326(7383):248-253

• Cancer Incidence and Mortality in England and Wales: Trends and Risk Factors

  Swerdlow, A.J.; Dos Santos Silva, I.; Doll, R.

  Oxford University Press (Oxford) 2001

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