Haleema Shakur BSc MSc RGN

Senior Lecturer

• Affiliation
• Teaching
• Research
• Publications

• 
• Room 185
• LSHTM
• Keppel Street
• London
• WC1E 7HT
• T: +44(0)20 7958 8113
• F: +44(0)20 7299 4663
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I am a Senior Lecturer - Clinical Trials Unit and have been at LSHTM since 2002. My primary research focus is in the conduct of clinical trials in critical emergency conditions, to determine the effectiveness of time critical interventions.  Research include the MRC-CRASH trial which is a randomised controlled trial designed to determine the effect of corticosteroid in traumatic brain injury. This trial was the largest to be conducted in traumatic brain injury and included over 10,000 participants and to date is the only trial to provide Class A evidence for the treatment of traumatic brain injury.  I also had a lead role in the CRASH-2 trial which is a randomised controlled trial designed to determine the effect of tranexamic acid on mortality in patients with traumatic bleeding. This trial recruited over 20,000 participants on time and on budget. The CRASH-2 trial impacted directly the clinical care of patients globally within one year of the first presentation of the results. The results led directly to tranexamic acid being included in the WHO list of essential medicines and its incorporation into civilian and military trauma guidelines world-wide.

In addition, I was one of the lead investigator in the BRAIN Trial an early phase trial looking at the effect of bradykinin B2 receptor antagonist as a treatment for traumatic brain injury.  I am the principal investigator of the WOMAN Trial which is looking at the effect of tranexamic acid as a treatment for postpartum haemorrhage. 

Affiliation

• Department of Nutrition and Public Health Intervention Research
• Faculty of Epidemiology and Population Health

Teaching

I am currently a tutor on the Distance Learning MSc Clinical Trials (www.lshtm.ac.uk/prospectus/masters/dmsct.html) and Module Organiser for CT210 (Integrating Module). Since the start of this MSc I have taught on several modules other  including CT103, 104, 201, 203, 204 and 205.

Research

I work with an amazing global group of people on clinical trials in critical emergency situations (see http://www.trialscoordinatingcentre.lshtm.ac.uk/)

• Selected publications

• Haemostatic drugs for traumatic brain injury.

  Perel, P.; Roberts, I.; Shakur, H.; Thinkhamrop, B.; Phuenpathom, N.; Yutthakasemsunt, S.;

  Cochrane Database Syst Rev, 2010; (1):CD007877

• Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial.

  CRASH-2 trial collaborators, .; Shakur, H.; Roberts, I.; Bautista, R.; Caballero, J.; Coats, T.; Dewan, Y.; El-Sayed, H.; Gogichaishvili, T.; Gupta, S.; Herrera, J.; Hunt, B.; Iribhogbe, P.; Izurieta, M.; Khamis, H.; Komolafe, E.; Marrero, M.A.; Mej?a-Mantilla, J.; Miranda, J.; Morales, C.; Olaomi, O.; Olldashi, F.; Perel, P.; Peto, R.; Ramana, P.V.; Ravi, R.R.; Yutthakasemsunt, S.;

  Lancet, 2010; 376(9734):23-32

• Anti-fibrinolytic agents in post partum haemorrhage: a systematic review.

  Ferrer, P.; Roberts, I.; Sydenham, E.; Blackhall, K.; Shakur, H.;

  BMC Pregnancy Childbirth, 2009; 9:29

• The BRAIN TRIAL: a randomised, placebo controlled trial of a Bradykinin B2 receptor antagonist (Anatibant) in patients with traumatic brain injury.

  Shakur, H.; Andrews, P.; Asser, T.; Balica, L.; Boeriu, C.; Quintero, J.D.; Dewan, Y.; Druw?, P.; Fletcher, O.; Frost, C.; Hartzenberg, B.; Mantilla, J.M.; Murillo-Cabezas, F.; Pachl, J.; Ravi, R.R.; R?tsep, I.; Sampaio, C.; Singh, M.; Svoboda, P.; Roberts, I.;

  Trials, 2009; 10:109

• Clinical trials in emergency situations - New guidance allows patients to be enrolled without prior consent

  Shakur, H.; Roberts, I.; Barnetson, L.; Coats, T.

  British Medical Journal, 2007; 334(7586):165-166

• Marketing and clinical trials: a case study.

  Francis, D.; Roberts, I.; Elbourne, D.R.; Shakur, H.; Knight, R.C.; Garcia, J.; Snowdon, C.; Entwistle, V.A.; McDonald, A.M.; Grant, A.M.; Campbell, M.K.;

  Trials, 2007; 8(1):37

• Towards sustainable clinical trials

  Burnett, J.; Clarke, M.; Darbyshire, J.; Haines, A.; Roberts, I.; Shakur, H.; Siegfried, N.; Wilkinson, P.

  British Medical Journal, 2007; 334(7595):671-673

• Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial.

  Roberts, I.; Yates, D.; Sandercock, P.; Farrell, B.; Wasserberg, J.; Lomas, G.; Cottingham, R.; Svoboda, P.; Brayley, N.; Mazairac, G.; Laloe, V.; Murillo-Sanchez, A.; Arango, M.; Hartzenberg, B.; Khamis, H.; Yutthakasemsunt, S.; Komolafe, E.; Olldashi, F.; Yadav, Y.; Murillo-Cabezas, F.; Shakur, H.; Edwards, P.;

  Lancet, 2004; 364(9442):1321-8

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