Dr Nuno Sepulveda MSc PhD
- Room 258d
- LSHTM
- Keppel Street
- London
- WC1E 7HT
- T: +44 (0)2076127841
Nuno Sepulveda is a Research fellow in Statistical Genetics and Genetic Epidemiology and a distance-learning tutor in the Human Genetic Epidemiology course at LSTHM. His expertise ranges different areas of Biostatistics with papers published in Statistical Genetics, Immunology, Medicine, Virology, among others. His current research interest comprises the study of human genetics of Malaria and the detection of genomic variation in general.
In the past he undertook studies (MSc and PhD) at the Gulbenkian Institute for Science in Portugal, where he developed new statistical methods for two-locus genetic interaction and comprehensive mathematical models of immunophysiology aiming to understand the genesis of autoimmune diseases.
Affiliation
Research areas
- Bayesian Analysis
- Human genetics
- Statistical methods
- T-cell immunology
Disciplines
- Epidemiology
- Genetic epidemiology
- Genetics
- Genomics
- Statistics
Disease and Health Conditions
- Malaria
Other interests
- Biodiversity
- R statistical language
- Statistical methodology
- Statistical modelling
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Selected publications
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Estimation of T-cell repertoire diversity and clonal size distribution by Poisson abundance models.
Sepúlveda, N.; Paulino, C.D.; Carneiro, J.;
J Immunol Methods, 2010; 353(1-2):124-37
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Transforming growth factor beta 2 and heme oxygenase 1 genes are risk factors for the cerebral malaria syndrome in Angolan children.
Sambo, M.R.; Trovoada, M.J.; Benchimol, C.; Quinhentos, V.; Gonçalves, L.; Velosa, R.; Marques, M.I.; Sepúlveda, N.; Clark, T.G.; Mustafa, S.; Wagner, O.; Coutinho, A.; Penha-Gonçalves, C.;
PLoS One, 2010; 5(6):e11141
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A central role for free heme in the pathogenesis of severe sepsis.
Larsen, R.; Gozzelino, R.; Jeney, V.; Tokaji, L.; Bozza, F.A.; Japiassú, A.M.; Bonaparte, D.; Cavalcante, M.M.; Chora, A.; Ferreira, A.; Marguti, I.; Cardoso, S.; Sepúlveda, N.; Smith, A.; Soares, M.P.;
Sci Transl Med, 2010; 2(51):51ra71
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Bayesian analysis of allelic penetrance models for complex binary traits
Sepulveda, N.; Paulino, C.D.; Penha-Goncalves, C.
Computational Statistics & Data Analysis, 2009; 53(4):1271-1283
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Allelic penetrance approach as a tool to model two-locus interaction in complex binary traits.
Sepúlveda, N.; Paulino, C.D.; Carneiro, J.; Penha-Gonçalves, C.;
Heredity, 2007; 99(2):173-84
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