Professor Ian Roberts MB BCh FRCP FPH
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Ian Roberts is Professor of Epidemiology & Public Heath and co-director of the Clinical Trials Unit at the London School of Hygiene & Tropical Medicine. His main research interests are improving emergency care and the links between energy and health. He trained as a paediatrician and then in epidemiology at the University of Auckland, New Zealand and at McGill University, Canada. He established and is co-ordinating editor of the Cochrane Injuries Group, an international network of individuals that prepares and maintains systematic reviews of the effectiveness of interventions in the prevention, treatment and rehabilitation of injury. He is principal investigator of the CRASH trials, large international randomised controlled trials that seek better ways to treat seriously injured trauma patients. The MRC CRASH trial, which included 10,000 pateints with head injury from around the world, showed that corticosteroids, which were widely used in the management of head injury, did not improve patient outcome after head injury but increased the risk of death. The CRASH-2 trial has shown that tranexamic acid, an inexpensive and widely practicable treatment, safely reduces mortality in bleeding trauma patients. He is the author with Phil Edwards of The Energy Glut: the politics of fatness in an overheating world.
Clinical Trials Energy and Health Epidemiology
Large scale clinical trials, prognostic research, energy and health.
- Climate change
- Clinical trials
- Complex interventions
- Drug discovery and development
- Public health
Disease and Health Conditions
Antifibrinolytic drugs for acute traumatic injury.
Roberts, I.; Shakur, H.; Ker, K.; Coats, T.; on behalf of the CRASH2 Trial collaborators, .;
Cochrane Database Syst Rev, 2011; 1:CD004896
The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial.
CRASH-2 collaborators, . ; Roberts, I. ; Shakur, H. ; Afolabi, A. ; Brohi, K. ; Coats, T. ; Dewan, Y. ; Gando, S. ; Guyatt, G. ; Hunt, B.J. ; Morales, C. ; Perel, P. ; Prieto-Merino, D. ; Woolley, T. ;
Lancet, 2011; 377(9771):1096-101, 1101.e1-2
Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial.
CRASH-2 trial collaborators, .; Shakur, H.; Roberts, I.; Bautista, R.; Caballero, J.; Coats, T.; Dewan, Y.; El-Sayed, H.; Gogichaishvili, T.; Gupta, S.; Herrera, J.; Hunt, B.; Iribhogbe, P.; Izurieta, M.; Khamis, H.; Komolafe, E.; Marrero, M.A.; Mej?a-Mantilla, J.; Miranda, J.; Morales, C.; Olaomi, O.; Olldashi, F.; Perel, P.; Peto, R.; Ramana, P.V.; Ravi, R.R.; Yutthakasemsunt, S.;
Lancet, 2010; 376(9734):23-32
Comparison of treatment effects between animal experiments and clinical trials: systematic review.
Perel, P.; Roberts, I.; Sena, E.; Wheble, P.; Briscoe, C.; Sandercock, P.; Macleod, M.; Mignini, L.E.; Jayaram, P.; Khan, K.S.;
BMJ, 2007; 334(7586):197
Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury-outcomes at 6 months.
Edwards, P.; Arango, M.; Balica, L.; Cottingham, R.; El-Sayed, H.; Farrell, B.; Fernandes, J.; Gogichaisvili, T.; Golden, N.; Hartzenberg, B.; Husain, M.; Ulloa, M.I.; Jerbi, Z.; Khamis, H.; Komolafe, E.; Laloe, V.; Lomas, G.; Ludwig, S.; Mazairac, G.; Munoz Sanchez, M.d.e. .L.; Nasi, L.; Olldashi, F.; Plunkett, P.; Roberts, I.; Sandercock, P.; Shakur, H.; Soler, C.; Stocker, R.; Svoboda, P.; Trenkler, S.; Venkataramana, N.K.; Wasserberg, J.; Yates, D.; Yutthakasemsunt, S.;
Lancet, 2005; 365(9475):1957-9
Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial.
Roberts, I.; Yates, D.; Sandercock, P.; Farrell, B.; Wasserberg, J.; Lomas, G.; Cottingham, R.; Svoboda, P.; Brayley, N.; Mazairac, G.; Laloe, V.; Murillo-Sanchez, A.; Arango, M.; Hartzenberg, B.; Khamis, H.; Yutthakasemsunt, S.; Komolafe, E.; Olldashi, F.; Yadav, Y.; Murillo-Cabezas, F.; Shakur, H.; Edwards, P.;
Lancet, 2004; 364(9442):1321-8
Colloids versus crystalloids for fluid resuscitation in critically ill patients.
Roberts, I.; Alderson, P.; Bunn, F.; Chinnock, P.; Ker, K.; Schierhout, G.;
Cochrane Database Syst Rev, 2004; 4(4):CD000567
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