Professor Eleanor Riley BSc BVSc PhD FSB FMedSci
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Eleanor Riley graduated from Bristol University with degrees in Cellular Pathology and Veterinary Science. After an internship in Veterinary Pathology at Cornell University (USA) she studied for a PhD in immunology and parasitology in the Department of Veterinary Pathology at the University of Liverpool. She began working on the immunology of malaria in 1985, as a member of the senior scientific staff at the Medical Research Council Laboratories in The Gambia, West Africa. In 1990, Eleanor moved to the University of Edinburgh as a Wellcome Trust Senior Research Fellow. Eleanor moved to the London School of Hygiene and Tropical Medicine in October 1998 where she is Professor of Infectious Disease Immunology. Eleanor is currently Chair of the BBSRC Bioscience for Health Strategy Advisory Panel and Deputy Chair of the MRC Infections and Immunity Board.
MSc Immunology of Infectious Diseases - core immunology course, advanced immunology (memory) and parasite immunology (malaria).
MSc Medical Parasitology - core course, immunology of malaria.
Our work concentrates on understanding the cellular and molecular mechanisms of immunity to infection, with a longstanding interest in anti-malarial immunity. We study the immunological consequences of malaria infection in endemic and non-endemic populations, conducting immuno-epidemiological studies of the relationship between defined immune responses and acquisition of clinically protective immunity, and relate these observations to data from experimental model systems and in vitro studies. We also conduct research oriented to the development and evaluation of anti-malarial vaccines.
A major aspect of our ongoing work is the immunobiology of Natural Killer cells.
Current projects include (i) the contribution of Natural Killer cells to the induction and effector phases of vaccine-induced immunity, (ii) mechanisms of activation of NK cells by malaria infected red blood cells, (iii) differentiation and maturation of NK cells in UK and African populations, (iv) phenotype and function of NK cells in patients with myalgic encepahlitis/chronic fatiigue syndrome.
Current collaborations include:
- Imperial College, London: modelling of immune responses
- Medical Research Council Laboratories, The Gambia: studying cellular immune responses to vaccination.
- ICDR Kampala, Uganda: the immunology and seroepidemiology of malaria in areas of diverse malaria transmission.
- Human genetics
- Innate immunity
- T-cell immunology
- Genetic epidemiology
Disease and Health Conditions
- Chronic Fatigue Syndrome
- Infectious disease
- Least developed countries: UN classification
- Sub-Saharan Africa (all income levels)
- Gambia, The
Dynamics of the antibody response to Plasmodium falciparum infection in African children.
White, M.T. ; Griffin, J.T. ; Akpogheneta, O. ; Conway, D.J. ; Koram, K.A. ; Riley, E.M. ; Ghani, A.C. ;
J Infect Dis, 2014;
Rapid natural killer cell differentiation in a population with near universal human cytomegalovirus infection is attenuated by NKG2C deletions.
Goodier, M.R. ; White, M.J. ; Darboe, A. ; Nielsen, C.M. ; Goncalves, A. ; Bottomley, C. ; Moore, S.E. ; Riley, E.M. ;
Immune mechanisms in malaria: new insights in vaccine development.
Riley, E.M. ; Stewart, V.A. ;
Nat Med, 2013; 19(2):168-78
IL-27 Receptor Signalling Restricts the Formation of Pathogenic, Terminally Differentiated Th1 Cells during Malaria Infection by Repressing IL-12 Dependent Signals.
Villegas-Mendez, A. ; de Souza, J.B. ; Lavelle, S.W. ; Gwyer Findlay, E. ; Shaw, T.N. ; van Rooijen, N. ; Saris, C.J. ; Hunter, C.A. ; Riley, E.M. ; Couper, K.N. ;
PLoS Pathog, 2013; 9(4):e1003293
Malaria impairs resistance to Salmonella through heme- and heme oxygenase-dependent dysfunctional granulocyte mobilization.
Cunnington, A.J.; de Souza, J.B.; Walther, M.; Riley, E.M.;
Nat Med, 2012; 18(1):120-7
The CTLA-4 and PD-1/PD-L1 Inhibitory Pathways Independently Regulate Host Resistance to Plasmodium-induced Acute Immune Pathology.
Hafalla, J.C. ; Claser, C. ; Couper, K.N. ; Grau, G.E. ; Renia, L. ; de Souza, J.B. ; Riley, E.M. ;
PLoS Pathog, 2012; 8(2):e1002504
Prolonged Neutrophil Dysfunction after Plasmodium falciparum Malaria Is Related to Hemolysis and Heme Oxygenase-1 Induction.
Cunnington, A.J.; Njie, M.; Correa, S.; Takem, E.N.; Riley, E.M.; Walther, M.;
J Immunol, 2012; 189(11):5336-46
NK Cells as Effectors of Acquired Immune Responses: Effector CD4+ T Cell-Dependent Activation of NK Cells Following Vaccination.
Horowitz, A.; Behrens, R.H.; Okell, L.; Fooks, A.R.; Riley, E.M.;
J Immunol, 2010; 185(5):2808-18
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