Eleanor Riley BSc BVSc PhD
- Room 236
- LSHTM
- Keppel Street
- London
- WC1E 7HT
- T: 44 20 7927 2706
- F: 44 20 7637 4314
Eleanor Riley graduated from Bristol University with degrees in Cellular Pathology and Veterinary Science. After an internship in Veterinary Pathology at Cornell University (USA) she studied for a PhD in immunology and parasitology in the Department of Veterinary Pathology at the University of Liverpool. She began working on the immunology of malaria in 1985, as a member of the senior scientific staff at the Medical Research Council Laboratories in The Gambia, West Africa. In 1990, Eleanor moved to the University of Edinburgh as a Wellcome Trust Senior Research Fellow. Eleanor moved to the London School of Hygiene and Tropical Medicine in October 1998 where she is Professor of Infectious Disease Immunology and Head of the Department of Immunology and Infection.
Affiliation
Teaching
MSc Immunology of Infectious Diseases - core immunology course, advanced immunology (memory) and parasite immunology (malaria).
MSc Medical Parasitology - core course, immunology of malaria.
Research
Our work concentrates on understanding the cellular and molecular mechanisms of immunity to infection, with a longstanding interest in anti-malarial immunity. We study the immunological consequences of malaria infection in endemic and non-endemic populations, conducting immuno-epidemiological studies of the relationship between defined immune responses and acquisition of clinically protective immunity, and relate these observations to data from experimental model systems and in vitro studies. Our aim is to characterise the effector mechanisms of both innate and acquired immunity to malaria, to understand how these mechanisms are induced and how they are regulated in order to promote parasite clearance without inducing immunopathology. We also conduct research oriented to the development and evaluation of anti-malarial and anti-viral vaccines.
Current projects include (i) the contribution of Natural Killer cells to the induction and effector phases of vaccine-induced immunity, (ii) mechanisms of immunoregulation during malaria infection, especially the balance between pro-inflammatory and anti-inflammatory mechanisms, (iii) induction and maintenance of T and B cell memory to malaria and (iv) use of serological techniques to map and monitor changes in malaria transmission.
Current collaborations include:
- Imperial College, London: studying patterns of immune responses to diverse malaria antigens and their association with protective immunity; and studying interactions between malaria infected red blood cells and Natural Killer cells.
- Medical Research Council Laboratories, The Gambia: studying cellular immune responses to vaccination.
- Chang Mai University, Thailand: studying the induction and maintenance of immunological memory in an area of very low endemic malaria transmission.
- ICDR Kampala, Uganda: studying the seroepidemiology of malaria in areas of diverse malaria transmission.
Research areas
- Immunoepidemiology
- Infectious disease
- Innate immunity
- Malaria
- Vaccines
Disciplines
- Immunology
- Pathology
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Selected publications
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Short-Lived IFN-gamma Effector Responses, but Long-Lived IL-10 Memory Responses, to Malaria in an Area of Low Malaria Endemicity
Wipasa, J.; Okell, L.; Sakkhachornphop, S.; Suphavilai, C.; Chawansuntati, K.; Liewsaree, W.; Hafalla, J.C.R.; Riley, E.M.
Plos Pathogens, 2011; 7(2)
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Effect of the Pre-erythrocytic Candidate Malaria Vaccine RTS,S/AS01(E) on Blood Stage Immunity in Young Children
Bejon, P.; Cook, J.; Bergmann-Leitner, E.; Olotu, A.; Lusingu, J.; Mwacharo, J.; Vekemans, J.; Njuguna, P.; Leach, A.; Lievens, M.; Dutta, S.; von Seidlein, L.; Savarese, B.; Villafana, T.; Lemnge, M.M.; Cohen, J.; Marsh, K.; Corran, P.H.; Angov, E.; Riley, E.M.; Drakeley, C.J.
Journal of Infectious Diseases, 2011; 204(1):9-18
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Parasite-Derived Plasma Microparticles Contribute Significantly to Malaria Infection-Induced Inflammation through Potent Macrophage Stimulation.
Couper, K.N.; Barnes, T.; Hafalla, J.C.; Combes, V.; Ryffel, B.; Secher, T.; Grau, G.E.; Riley, E.M.; de Souza, J.B.;
PLoS Pathog, 2010; 6(1):e1000744
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Long-lived antibody and B Cell memory responses to the human malaria parasites, Plasmodium falciparum and Plasmodium vivax.
Wipasa, J.; Suphavilai, C.; Okell, L.C.; Cook, J.; Corran, P.H.; Thaikla, K.; Liewsaree, W.; Riley, E.M.; Hafalla, J.C.;
PLoS Pathog, 2010; 6(2):e1000770
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Cross-Talk between T Cells and NK Cells Generates Rapid Effector Responses to Plasmodium falciparum-Infected Erythrocytes.
Horowitz, A.; Newman, K.C.; Evans, J.H.; Korbel, D.S.; Davis, D.M.; Riley, E.M.;
J Immunol, 2010;
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Essential Role for IL-27 Receptor Signaling in Prevention of Th1-Mediated Immunopathology during Malaria Infection
Findlay, E.G.; Greig, R.; Stumhofer, J.S.; Hafalla, J.C.R.; de Souza, J.B.; Saris, C.J.; Hunter, C.A.; Riley, E.M.; Couper, K.N.
Journal of Immunology, 2010; 185(4):2482-2492
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NK Cells as Effectors of Acquired Immune Responses: Effector CD4+ T Cell-Dependent Activation of NK Cells Following Vaccination.
Horowitz, A.; Behrens, R.H.; Okell, L.; Fooks, A.R.; Riley, E.M.;
J Immunol, 2010;
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Distinct Roles for FOXP3(+) and FOXP3(-) CD4(+) T Cells in Regulating Cellular Immunity to Uncomplicated and Severe Plasmodium falciparum Malaria
Walther, M.; Jeffries, D.; Finney, O.C.; Njie, M.; Ebonyi, A.; Deininger, S.; Lawrence, E.; Ngwa-Amambua, A.; Jayasooriya, S.; Cheeseman, I.H.; Gomez-Escobar, N.; Okebe, J.; Conway, D.J.; Riley, E.M.
PLOS Pathogens, 2009; 5(4)
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