Dr Ross Paveley Bsc MSc PhD

Research Fellow

• Affiliation
• Research
• Publications

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Currently I am a research fellow at the London School of Hygiene & Tropical Medicine, London, UK. I trained previously as a parasitologist at the Centre for Immunology and Infection at the University of York, UK on Schistosome immunology and completed my doctorate on imaging the infection of Schistosoma mansoni larvae into host skin. After periods of work overseas and working in the laboratory on helminth diseases and the resulting immune response I am now conducting research into the discovery of new drugs against Schistosomes at LSHTM. This involves developing a whole organism high content screening system based on automatic image capture and analysis of schistosome larva phenotypes and motility.

Affiliation

• Immunology and Infection Department
• Faculty of Infectious and Tropical Diseases

Research

Only one drug, praziquantel, is widely available for treatment of schistosomes and due to its increasing usage and the possibility of developing drug resistance, there is an urgent need to discover/develop new drugs. Previous in vitro whole organism screens have involved manual microscopic visualization of damage to adult schistosome worms recovered ex-vivo from mice or to larval schistosomes produced in vitro. These screening methods are low/medium throughput and only allow screening of small focused compound libraries. Our current work has resulted in the first automated high-throughput whole organism screening platform for schistosomicidal activity. This new platform uses a robotic, integrated, high-throughput system based on automated image capture and analysis of drug efficacy using newly designed analysis software in Pipeline Pilot. This involves integrated assessment of both larval motility based on time lapse imaging and morphological phenotype based on a Bayesian prediction model. The analysis gives a quantitative score of drug efficacy and also classifies the morphological  phenotype according to similarity to the effects of different known schistosome active compounds . This development makes it feasible, for the first time, to screen very large compound collections and hopefully yield new lead compounds. 

• Selected publications

• CD4CD25 Regulatory Cells Contribute to the Regulation of Colonic Th2 Granulomatous Pathology Caused by Schistosome Infection.

  Turner, J.D. ; Jenkins, G.R. ; Hogg, K.G. ; Aynsley, S.A. ; Paveley, R.A. ; Cook, P.C. ; Coles, M.C. ; Mountford, A.P. ;

  PLoS Negl Trop Dis, 2011; 5(8):e1269

• The Mannose Receptor (CD206) is an important pattern recognition receptor (PRR) in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFN? production.

  Paveley, R.A. ; Aynsley, S.A. ; Turner, J.D. ; Bourke, C.D. ; Jenkins, S.J. ; Cook, P.C. ; Martinez-Pomares, L. ; Mountford, A.P. ;

  Int J Parasitol, 2011;

• Fluorescent Imaging of Antigen Released by a Skin-Invading Helminth Reveals Differential Uptake and Activation Profiles by Antigen Presenting Cells

  Paveley, R.A.; Aynsley, S.A.; Cook, P.C.; Turner, J.D.; Mountford, A.P.

  PLoS Negl Trop Dis, 2009; 3(10):e528-e528

• CD207+ Langerhans cells constitute a minor population of skin-derived antigen-presenting cells in the draining lymph node following exposure to Schistosoma mansoni

  Kumkate, S.; Jenkins, G.R.; Paveley, R.A.; Hogg, K.G.; Mountford, A.P.

  International Journal for Parasitology, 2007; 37(2):209-220

• → View all Dr Ross Paveley's publications

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