Juan Pablo-Casas (nee Casas)MD PhD

Professor of Epidemiology

Juan Pablo-Casas's Background

 

I qualified in Medicine in 1999 and continue to train in cardiovascular science. Since 2002 I have worked as a cardiovascular epidemiologist. Currently, I split my time between the LSTHM and University College London.  At LSTHM, I work as co-director of the British Women's Heart & Health Study and Co-ordinating editor of the Cochrane Heart Group. At University College London, I work as a Professor of Cardiovascular Epidemiology at the Institute of Cardiovascular Science.

Juan Pablo-Casas's Affiliation

Juan Pablo-Casas's Teaching

 

I have participated in in-house teaching activities for MSc students such as extended epidemiology, design and analyses of epidemiological studies, study design and genetic epidemiology as well as various short courses at LSHTM. For six years, I co-organized the non-communicable disease epidemiology unit for MSc students.

Juan Pablo-Casas's Research

My major interest is in Translational Epidemiology in Non-Communicable Diseases with focus on cardiovascular disorders. Specific areas of current research includes:

 

For this, I make use of large-scale observational studies to which I got access, those include:


Consortium of British cohorts: Together with Prof Aroon Hingorani at UCL, we co-lead the UCL, London School, Edinburgh and Bristol (UCLEB) consortium that include 14 British cohorts and ~30,000 participants with large-scale genomics and metabolomics data.

Pre-eclampsia: Together with Dr. Serrano, we set-up the GenPE study, one of the largest biobanks on pre-eclampsia world-wide. The GenPE is a case-control study that has recruited over 3600 cases and 4400 controls, including 2800 samples from the offsprings (www.genpe.org). This study has access to genome-wide arrays and the gene-centric array Immunochip, as well as data on blood markers of interest for pre-eclampsia. Since 2012, I am part of the InterPregGen consortia (funded by the EU 7th Framework programme), that includes research teams from several European countries to investigate the genetic determinants of pre-eclampsia.   

Women's Health: I am the Director of the British Women's Heart & Health Study a cohort of over 4000 women in 23 British towns, resource that is being use to investigate the causes and a consequence of cardiovascular disorders in older women. Our ongoing research focus on the uses of metabolomics to understand the mechanisms that leads to cardiovascular disease.

 

Research areas

  • Ageing
  • Drug discovery and development
  • Human genetics
  • Maternal health
  • Systematic reviews

Disciplines

  • Epidemiology
  • Genetic epidemiology
  • Genomics
  • Medicine
  • Molecular epidemiology
  • Pharmacology

Disease and Health Conditions

  • Cardiovascular disease
  • Diabetes
  • Non-communicable diseases
  • Stroke

Regions

  • Euro area
  • Latin America & Caribbean (all income levels)
  • North America

Other interests

  • MARCH
  • Mendelian randomization
  • drug development
  • metabolomics
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