Juan Pablo-Casas MD PhD

Senior Lecturer

• Affiliation
• Teaching
• Research
• Publications

• Room 255a
• LSHTM
• Keppel Street
• London
• WC1E 7HT
• T: + 44 (0)20 7927 2163

I qualified in Medicine in 1999 and continue to train in cardiovascular science. In the UK, I worked initially as a Clinical Research Fellow in Centre for Clinical Pharmacology at UCL and joined LSHTM in April 2005. Since April 2009 I split my time between the LSTHM and the University College London. At LSTHM, I work as co-director of the British Women's Heart & Health Study and Deputy Co-ordinator editor of the Cochrane Heart Group. At UCL, I worked as a Senior Genetic Epidemiologist at the Genetic Epidemiology group in Cardiovascular disorders.

Affiliation

• Department of Non-communicable Disease Epidemiology

Teaching

During my time at LSHTM, I have participated in teaching activities such as extended epidemiology, design and analyses of epidemiological studies, study design and genetic epidemiology. During the last six years, I co-organize with Prof Dave Leon the non-communicable disease epidemioloy unit for MSc students.

Research

My major interest is in disease aetiology in non-communicable disease with focus on cardiovascular disease and pre-eclampsia. For this, I make use of large-scale observational studies to which I got access, those include:

Cardiovascular cohorts in the UK: In collaboration with Prof Aroon Hingorani at UCL, we have succesfully conducted some of the pioneer experiments in Mendelian randomisation in cardiovascular disease, including those on Homocysteine-stroke, C-reactive protein and Coronary Heart Disease. More recently, I work in the use of a genetic approach for drug-target identification and validation. 

Pre-eclampsia: Since 1999 with Dr. Serrano, we set-up the GenPE study, a case-control study in pre-eclampsia. This study has recruited to October 2011 a total of 3585 cases and 4473 controls, including 2800 samples from the offsprings. Recruitment is still on-going (www.genpe.org). Using this study, a genome-wide association study  funded by Wellcome Trust was recently completed, as well as genotyping of  ~2700 samples using the large gene-centric array Immunochip, that contains 200K variants GWAs derived (http://www.wtccc.org.uk/ccc2/wtccc2_studies.shtml).

Cardiovascular disease Latin-America: In collaboration with Dr. Bautista at Wisconsin university, we have established a large consortium of population-based studies from Latin America to evaluate the impact of obesity and cardiovascular disease in the region (http://www.pophealth.wisc.edu/laso/).

Women's Health: From April 2009 I am working as co-Director of the British Women's Heart & Health Study a cohort of over 4000 women in 23 British towns, resource that is being use to investigate the causes and a consequence of cardiovascular disorders in older women. 

• Selected publications

• Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data.

  C Reactive Protein Coronary Heart Disease Genetics Collaboration (CCGC), . ; Wensley, F. ; Gao, P. ; Burgess, S. ; Kaptoge, S. ; Di Angelantonio, E. ; Shah, T. ; Engert, J.C. ; Clarke, R. ; Davey-Smith, G. ; Nordestgaard, B.G. ; Saleheen, D. ; Samani, N.J. ; Sandhu, M. ; Anand, S. ; Pepys, M.B. ; Smeeth, L. ; Whittaker, J. ; Casas, J.P. ; Thompson, S.G. ; Hingorani, A.D. ; Danesh, J. ;

  BMJ, 2011; 342:d548

• Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials.

  Holmes, M.V.; Newcombe, P.; Hubacek, J.A.; Sofat, R.; Ricketts, S.L.; Cooper, J.; Breteler, M.M.; Bautista, L.E.; Sharma, P.; Whittaker, J.C.; Smeeth, L.; Fowkes, F.G.; Algra, A.; Shmeleva, V.; Szolnoki, Z.; Roest, M.; Linnebank, M.; Zacho, J.; Nalls, M.A.; Singleton, A.B.; Ferrucci, L.; Hardy, J.; Worrall, B.B.; Rich, S.S.; Matarin, M.; Norman, P.E.; Flicker, L.; Almeida, O.P.; van Bockxmeer, F.M.; Shimokata, H.; Khaw, K.T.; Wareham, N.J.; Bobak, M.; Sterne, J.A.; Smith, G.D.; Talmud, P.J.; van Duijn, C.; Humphries, S.E.; Price, J.F.; Ebrahim, S.; Lawlor, D.A.; Hankey, G.J.; Meschia, J.F.; Sandhu, M.S.; Hingorani, A.D.; Casas, J.P.;

  Lancet, 2011; 378(9791):584-94

• Separating the Mechanism-Based and Off-Target Actions of Cholesteryl Ester Transfer Protein Inhibitors With CETP Gene Polymorphisms

  Sofat, R.; Hingorani, A.D.; Smeeth, L.; Humphries, S.E.; Talmud, P.J.; Cooper, J.; Shah, T.; Sandhu, M.S.; Ricketts, S.L.; Boekholdt, S.M.; Wareham, N.; Khaw, K.T.; Kumari, M.; Kivimaki, M.; Marmot, M.; Asselbergs, F.W.; van der Harst, P.; Dullaart, R.P.F.; Navis, G.; van Veldhuisen, D.J.; van Gilst, W.H.; Thompson, J.F.; McCaskie, P.; Palmer, L.J.; Arca, M.; Quagliarini, F.; Gaudio, C.; Cambien, F.; Nicaud, V.; Poirer, O.; Gudnason, V.; Isaacs, A.; Witteman, J.C.M.; van Duijn, C.M.; Pencina, M.; Vasan, R.S.; D'Agostino, R.B.; Ordovas, J.; LI, T.Y.; Kakko, S.; Kauma, H.; Savolainen, M.J.; Kesaniemi, Y.A.; Sandhofer, A.; Paulweber, B.; Sorli, J.V.; Goto, A.; Yokoyama, S.; Okumura, K.; Horne, B.D.; Packard, C.; Freeman, D.; Ford, I.; Sattar, N.; McCormack, V.; Lawlor, D.A.; Ebrahim, S.; Smith, G.D.; Kastelein, J.J.P.; Deanfield, J.; Casas, J.P.

  Circulation, 2010; 121(1):52-62

• PLA2G7 Genotype, Lipoprotein-Associated Phospholipase A2 Activity, and Coronary Heart Disease Risk in 10 494 Cases and 15 624 Controls of European Ancestry.

  Casas, J.P.; Ninio, E.; Panayiotou, A.; Palmen, J.; Cooper, J.A.; Ricketts, S.L.; Sofat, R.; Nicolaides, A.N.; Corsetti, J.P.; Fowkes, F.G.; Tzoulaki, I.; Kumari, M.; Brunner, E.J.; Kivimaki, M.; Marmot, M.G.; Hoffmann, M.M.; Winkler, K.; M?rz, W.; Ye, S.; Stirnadel, H.A.; Khaw, K.T.; Humphries, S.E.; Sandhu, M.S.; Hingorani, A.D.; Talmud, P.J.;

  Circulation, 2010;

• Insight into the nature of the CRP-coronary event association using Mendelian randomization.

  Casas, J.P.; Shah, T.; Cooper, J.; Hawe, E.; McMahon, A.D.; Gaffney, D.; Packard, C.J.; O'reilly, D.S.; Juhan-Vague, I.; Yudkin, J.S.; Tremoli, E.; Margaglione, M.; Di Minno, G.; Hamsten, A.; Kooistra, T.; Stephens, J.W.; Hurel, S.J.; Livingstone, S.; Colhoun, H.M.; Miller, G.J.; Bautista, L.E.; Meade, T.; Sattar, N.; Humphries, S.E.; Hingorani, A.D.;

  Int J Epidemiol, 2006; 35(4):922-31

• Angiotensin-converting enzyme I/D polymorphism and preeclampsia risk: Evidence of small-study bias

  Serrano, N.C.; Diaz, L.A.; Paez, M.C.; Mesa, C.M.; Cifuentes, R.; Monterrosa, A.; Gonzalez, A.; Smeeth, L.; Hingorani, A.D.; Casas, J.P.

  Plos Medicine, 2006; 3(12):2304-2316

• Homocysteine and stroke: evidence on a causal link from mendelian randomisation.

  Casas, J.P.; Bautista, L.E.; Smeeth, L.; Sharma, P.; Hingorani, A.D.;

  Lancet, 2005; 365(9455):224-32

• Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: systematic review and meta-analysis.

  Casas, J.P.; Chua, W.; Loukogeorgakis, S.; Vallance, P.; Smeeth, L.; Hingorani, A.D.; MacAllister, R.J.;

  Lancet, 2005; 366(9502):2026-33

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