Juan Pablo-Casas MD PhD

Professor of Epidemiology

Juan Pablo-Casas's Background

I qualified in Medicine in 1999 and continue to train in cardiovascular science. In the UK, I worked initially as a Clinical Research Fellow in Centre for Clinical Pharmacology at UCL and joined LSHTM in April 2005. Since April 2009 I split my time between the LSTHM and the University College London. At LSTHM, I work as co-director of the British Women's Heart & Health Study and Deputy Co-ordinator editor of the Cochrane Heart Group. At UCL, I work as a Reader in Genetic Epidemiology at the Institute of Cardiovsacular Science.

Juan Pablo-Casas's Affiliation

Juan Pablo-Casas's Teaching

During my time at LSHTM, I have participated in teaching activities such as extended epidemiology, design and analyses of epidemiological studies, study design and genetic epidemiology. During the last six years, I co-organized the non-communicable disease epidemioloy unit for MSc students.

Juan Pablo-Casas's Research

My major interest is in disease aetiology in non-communicable disease with focus on cardiovascular disease and pre-eclampsia. For this, I make use of large-scale observational studies to which I got access, those include:


Cardiovascular cohorts in the UK: Together with Prof Aroon Hingorani at UCL, we have succesfully conducted some of the pioneer experiments in Mendelian randomisation in cardiovascular disease, including those on Homocysteine-stroke, C-reactive protein and Coronary Heart Disease. More recently, I work in the use of a genetic approach for drug-target identification and validation. 

Pre-eclampsia: Since 1999 with Dr. Serrano, we set-up the GenPE study, a case-control study in pre-eclampsia. This study has recruited to October 2011 a total of 3585 cases and 4473 controls, including 2800 samples from the offsprings. Recruitment is still on-going (www.genpe.org). Using this study, a genome-wide association study  funded by Wellcome Trust was recently completed, as well as genotyping of  ~2700 samples using the large gene-centric array Immunochip, that contains 200K variants GWAs derived. Since 2012, I am part of the InterPregGen consortia (funded by the EU 7th Framework programme), that includes research teams from several European countries to investigate the genetic determinants of pre-eclampsia.    

Cardiovascular disease Latin-America: In collaboration with Dr. Bautista at Wisconsin university, we have established a large consortium of population-based studies from Latin America to evaluate the impact of obesity and cardiovascular disease in the region (http://www.pophealth.wisc.edu/laso/).

Women's Health: From April 2009 I am working as co-Director of the British Women's Heart & Health Study a cohort of over 4000 women in 23 British towns, resource that is being use to investigate the causes and a consequence of cardiovascular disorders in older women. Our ongoing work focus on the use of metabolomics to understand the mechanisms that lead to cardiovascular disease.

Research areas

  • Ageing
  • Drug discovery and development
  • Human genetics
  • Maternal health
  • Systematic reviews

Disciplines

  • Epidemiology
  • Genetic epidemiology
  • Genomics
  • Medicine
  • Molecular epidemiology

Disease and Health Conditions

  • Cardiovascular disease
  • Diabetes
  • Non-communicable diseases
  • Stroke

Regions

  • Euro area
  • Latin America & Caribbean (all income levels)
  • North America

Other interests

  • MARCH
  • Mendelian randomization
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