Dr Debbie Nolder BSc MSc PhD

Principal Scientific Officer Molecular Diagnostics

Background

Debbie joined the School in 1995 as a PhD student after obtaining her MSc in clinical parasitology (LSHTM / Royal Free Hospital School of Medicine). She had previously been employed at the PHLS Central Public Health Laboratory, Colindale (now PHE Centre for Infections), as a Clinical Scientist working on the development of immuno- and molecular diagnostic tests for protozoa associated with HIV infection.

Debbie's PhD investigated the genetic diversity, population structure and evolution of Leishmania populations belonging to the South American subgenus, Viannia.

Debbie has experience in monoclonal antibody production, mammalian cell culture and the in vitro cultivation of a broad range of protozoa plus extensive experience in molecular- and immunological-based research and diagnostic techniques.

Debbie is Lead BMS (molecular) in the PHE Malaria Reference Laboratory & LSHTM Diagnostic Parasitology Laboratory where she has a specialist interest in development and implementation of molecular diagnostic, typing and drug resistance assays for Plasmodium spp., and molecular diagnostic assays for diagnosis of Trypanosoma cruzi (Chagas disease), Acanthamoeba spp. (Acanthamoeba keratitis, AK) and Leishmania spp. infections.

Affiliation

Centres

Teaching

LSHTM MSc units: lecturer on core Parasitology/Entomology, core Molecular Biology, Advanced Diagnostic Parasitology, TMIH.  Summer project supervisor.  Tutor

LSHTM MSc (DBL): tutor for Parasitology (Advanced Unit).

LSHTM short-courses: DTM&H, DTN and other practical courses.

Training of visiting scientists, clinicians and BMSs in molecular diagnostics of malaria parasites.

Research

Molecular diagnostics, drug resistance and typing (particularly in respect of malaria, Chagas disease, leishmaniasis and Acanthamoeba infection).

 

Research areas

  • Diagnostics
  • Drug resistance
  • Methodology
  • Parasites
  • Trypanosomes

Disciplines

  • Epidemiology
  • Genetic epidemiology
  • Molecular biology
  • Parasitology

Disease and Health Conditions

  • Chagas Disease
  • Leishmaniasis
  • Malaria

Other interests

  • Acanthamoeba keratitis
  • Antimalarial Drug Resistance
  • Diagnostics,
  • Malaria Centre
  • Malaria diagnosis
  • Malaria diagnostic strategies
  • Microbial Keratitis
  • Microsatellites
  • Molecular Diagnostics
  • Plasmodium knowlesi
  • Plasmodium malariae
  • Plasmodium ovale
  • Plasmodium vivax
  • Tryanosoma cruzi
  • rapid diagnostic test (RDT)
  • real time quantitative PCR
  • teaching
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