Debbie Nolder BSc MSc PhD

Principal Scientific Officer

• Affiliation
• Teaching
• Research
• Publications

• 
• Malaria Reference Laboratory & Diagnostic Parasitology Laboratory
• LSHTM
• Keppel Street
• London
• WC1E 7HT
• T: +44 (0) 20 7927 2427
• F: +44 (0) 20 7637 0248

Debbie joined the School in 1995 as a PhD student after obtaining her MSc in clinical parasitology (LSHTM / Royal Free Hospital School of Medicine). She had previously been employed at the PHLS Central Public Health Laboratory, Colindale (now HPA Centre for Infections), as a Clinical Scientist working on the development of immuno- and molecular diagnostic tests for protozoa associated with HIV infection.

Debbie's PhD investigated the genetic diversity, population structure and evolution of Leishmania populations belonging to the South American subgenus, Viannia.

Debbie has experience in monoclonal antibody production, mammalian cell culture and the in vitro cultivation of a broad range of protozoa plus extensive experience in molecular- and immunological-based research and diagnostic techniques.

Debbie is a Principal Scientific Officer (BMS4) in the HPA Malaria Reference Laboratory / Diagnostic Parasitology Laboratory at LSHTM and has a specialist interest in development and implementation of molecular diagnostic and typing assays for Plasmodium spp., Trypanosoma cruzi, Leishmania spp. and free-living amoebae (Acanthamoeba, Balamuthia, Naegleria).

Affiliation

• Department of Pathogen Molecular Biology
• Faculty of Infectious and Tropical Diseases

Teaching

LSHTM MSc units: lecturer for core Molecular Biology, Advanced Diagnostic Parasitology, TMIH.  Summer project supervisor.  Tutor

LSHTM MSc (DBL): tutor for Parasitology (Advanced Unit).

LSHTM short-courses: DTM&H, DTN and other practical courses.

Training of visiting scientists and BMSs in molecular diagnostics of malaria parasites.

Research

Molecular diagnostics and typing (particularly in respect of malaria, Chagas disease, leishmaniasis and Acanthamoeba infection).

Molecular epidemiology of leishmaniasis.

• Selected publications

• Two Nonrecombining Sympatric Forms of the Human Malaria Parasite Plasmodium ovale Occur Globally.

  Sutherland, C.J.; Tanomsing, N.; Nolder, D.; Oguike, M.; Jennison, C.; Pukrittayakamee, S.; Dolecek, C.; Hien, T.T.; do Ros?rio, V.E.; Arez, A.P.; Pinto, J.; Michon, P.; Escalante, A.A.; Nosten, F.; Burke, M.; Lee, R.; Blaze, M.; Otto, T.D.; Barnwell, J.W.; Pain, A.; Williams, J.; White, N.J.; Day, N.P.; Snounou, G.; Lockhart, P.J.; Chiodini, P.L.; Imwong, M.; Polley, S.D.;

  J Infect Dis, 2010; 201(10):1544-50

• Human Infections with Plasmodium knowlesi, the Philippines.

  Luchavez, J.; Espino, F.; Curameng, P.; Espina, R.; Bell, D.; Chiodini, P.; Nolder, D.; Sutherland, C.; Lee, K.S.; Singh, B.;

  Emerg Infect Dis, 2008; 14(5):811-813

• Applying a Real Time Pcr Assay to the Routine Laboratory Diagnosis of Falciparum Malaria

  Checkley, A.; Burke, M.; Chiodini, P.L.; Nolder, D.; Sutherland, C.

  American Journal of Tropical Medicine and Hygiene, 2008; 79(6):954

• Multiple hybrid genotypes of leishmania (viannia) in a focus of mucocutaneous leishmaniasis.

  Nolder, D.; Roncal, N.; Davies, C.R.; Llanos-Cuentas, A.; Miles, M.A.;

  Am J Trop Med Hyg, 2007; 76(3):573-8

• Acanthamoeba genotype T4 from the UK and Iran and isolation of the T2 genotype from clinical isolates.

  Maghsood, A.H.; Sissons, J.; Rezaian, M.; Nolder, D.; Warhurst, D.; Khan, N.A.;

  J Med Microbiol, 2005; 54(Pt 8):755-9

• Recrudescence of imported falciparum malaria after quinine therapy: potential drug interaction with phenytoin

  Fabre, C.; Criddle, J.; Nolder, D.; Klein, J. L.

  Transactions of the Royal Society of Tropical Medicine and Hygiene, 2005; 99(11):871-873

• Post-mortem culture of Balamuthia mandrillaris from the brain and cerebrospinal fluid of a case of granulomatous amoebic meningoencephalitis, using human brain microvascular endothelial cells.

  Jayasekera, S.; Sissons, J.; Tucker, J.; Rogers, C.; Nolder, D.; Warhurst, D.; Alsam, S.; White, J.M.; Higgins, E.M.; Khan, N.A.;

  J Med Microbiol, 2004; 53(10):1007-1012

• In vitro activity of nitazoxanide and related compounds against isolates of Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis

  Adagu, I. S.; Nolder, D.; Warhurst, D. C.; Rossignol, J. F.

  Journal of Antimicrobial Chemotherapy, 2002; 49(1):103-11

• → View all Debbie Nolder's publications

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