Mariam Molokhia BSc MBChB MRCGP PhD
- LSHTM
- Keppel Street
- London
- WC1E 7HT
- T: +44 (0)20 7927 2633
- F: +44 (0)20 7580 6897
I trained in medicine at St. Andrews and Manchester and have been at the school since 1998. I am currently also working as a GP in South London.
Affiliation
Teaching
I am involved with MSc teaching in genetic epidemiology, statistics and epidemiology. I also teach 2 PhD students. I am an accredited member of the ILT (Institute for Learning and Teaching) and a GP appraiser.
Research
My interests include genetic epidemiology of complex traits including hypertension and systemic lupus erythematosus in admixed African/European populations (in Trinidad & Tobago). The group has received funding from the Medical Research Council and the Arthritis Research Campaign, and fieldwork and genotyping for these studies has now been completed, with analyses underway. Novel work includes quantification of admixture in diverse populations using the program ADMIXMAP. Other areas of research relate to pharmaco-epidemiology of adverse drug reactions, and include the EUDRAGENE project: European case-control collection of genetic susceptibility to adverse drug reactions www.EUDRAGENE.org I recently completed a personal award from the NCCRCD to study signal detection for adverse drug reactions (ADRs). THis work is complementing part of a European FP7 project led by colleagues in the Netherlands. Genetic studies of susceptibility to ADRs are currently underway in 2010 as part of an international consortium. In 2011 together with collaborators, GWAS have been published on hypersensititivy reactions.
EUDRAGENE is involved with the following initiatives concerning adverse drug reactions:
Serious Adverse Event Consortium
www.euadr-project.org
The ARITMO PROJECT www.aritmo-project.org
Research areas
- Clinical databases
- Statistical methods
Disciplines
- Epidemiology
- Genetics
- Genomics
- Pharmacoepidemiology
- Pharmacology
Disease and Health Conditions
- Cardiovascular disease
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Selected publications
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30 year patterns of mortality in tobago, west indies, 1976-2005: impact of glucose intolerance and alcohol intake.
Molokhia, M.; Nitsch, D.; Patrick, A.L.; McKeigue, P.;
PLoS One, 2011; 6(1):e14588
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Harmonising Definitions of Adverse Events among 8 European Healthcare Databases Participating in the Eu-Adr Project
Gini, R.; Avillach, P.; Coloma, P.M.; Mougin, F.; Dufour, J.C.; Thiessard, F.; Joubert, M.; Mazzaglia, G.; Giaquinto, C.; Fornari, C.; Herings, R.; Hippisley-Cox, J.; Molokhia, M.; Pedersen, L.; Fourrier-Reglat, A.; Fieschi, M.; Sturkenboom, M.; van der Lei, J.; Pariente, A.; Trifiro, G.
Epidemiologia & Prevenzione, 2010; 34(5-6):89-90
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Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy
Dixon, P.H.; van Mil, S.W.C.; Chambers, J.; Strautnieks, S.; Thompson, R.J.; Lammert, F.; Kubitz, R.; Keitel, V.; Glantz, A.; Mattsson, L.A.; Marschall, H.U.; Molokhia, M.; Moore, G.E.; Linton, K.J.; Williamson, C.
Gut, 2009; 58(4):537-544
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Data mining on electronic health record databases for signal detection in pharmacovigilance: which events to monitor?
Trifiro, G.; Pariente, A.; Coloma, P.M.; Kors, J.A.; Polimeni, G.; Miremont-Salame, G.; Catania, M.A.; Salvo, F.; David, A.; Moore, N.; Caputi, A.P.; Sturkenboom, M.; Molokhia, M.; Hippisley-Cox, J.; Acedo, C.D.; van der Lei, J.; Fourrier-Reglat, A.; Grp, E.-A.
Pharmacoepidemiology and Drug Safety, 2009; 18(12):1176-1184
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Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database
Tzoulaki, I.; Molokhia, M.; Curcin, V.; Little, M.P.; Millett, C.J.; Ng, A.; Hughes, R.I.; Khunti, K.; Wilkins, M.R.; Majeed, A.; Elliott, P.
British Medical Journal, 2009; 339
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Limits to causal inference based on Mendelian randomization: a comparison with randomized controlled trials.
Nitsch, D.; Molokhia, M.; Smeeth, L.; De Stavola, B.L.; Whittaker, J.C.; Leon, D.A.;
Am J Epidemiol, 2006; 163(5):397-403
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EUDRAGENE: European collaboration to establish a case-control DNA collection for studying the genetic basis of adverse drug reactions.
Molokhia, M.; McKeigue, P.;
Pharmacogenomics, 2006; 7(4):633-8
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MDR1 gene polymorphisms are associated with neuropsychiatric adverse effects of mefloquine.
Aarnoudse, A.L.; van Schaik, R.H.; Dieleman, J.; Molokhia, M.; van Riemsdijk, M.M.; Ligthelm, R.J.; Overbosch, D.; van der Heiden, I.P.; Stricker, B.H.;
Clin Pharmacol Ther, 2006; 80(4):367-374
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