Dr Ruth Mcnerney CBiol MIBiol PhD
- Room 384
- Keppel Street
- WC1E 7HT
- T: +44 (0) 20 7927 2346
- F: +44 (0) 20 7637 4314
Ruth McNerney's research includes the development, adaptation and evaluation of tools for the control of tuberculosis. This includes diagnosis, detection of drug resistance, molecular epidemiology and whole genome sequencing. She also has an interest in transmission of the disease. She is experienced in molecular techniques, immunoassay, and previously developed a simple, rapid, low-cost test for drug susceptibility using bacteriophages. She has a strong interest in POC tests and current activities include the application of artifical nose technology and RPA, a new isothermal nucleic acid amplification technology for the diagnosis of tuberculosis. She has also developed patient based educational materials to assist diagnosis. She is a member of the STOP TB Working Group on New Diagnostics and chairs the subgroup on point-of-care tests. Her most recent publication is on aerosol production by the vuvuzela, the plastic blowing horn used by soccer fans.
Ruth is a tutor for the Tuberculosis Module of the distance learning MSc program. She also teaches and tutors students for the 'in-house' MSc courses, including Medical Microbiology, Molecular Biology of Infectious Diseases and Control of Infectious Diseases.
Research activities include the development and evaluation of tests for diagnosis of tuberculosis and the detection of drug resistance. The laboratory also undertakes molecular typing (fingerprinting) including RFLP, spoligotyping and VNTR/MIRU.
Current projects include
- Ultrasensitive nanosensor arrays for detection of VOC biomarkers of tuberculosis.
- Feasability of using Recombinase Polymerase Amplification for a rapid point of care test for tuberculosis.
- Evaluation of a novel antigen for detection of TB.
- Whole genome sequencing of clinical isolates of Mycobacterium tuberculosis.
- Drug resistance
- Molecular epidemiology
- Operational research
Disease and Health Conditions
- Infectious disease
- MDR TB
Production of volatile organic compounds by mycobacteria.
McNerney, R. ; Mallard, K. ; Okolo, P.I. ; Turner, C. ;
FEMS Microbiol Lett, 2012;
Microscopy compared to culture for the diagnosis of tuberculosis in induced sputum samples: a systematic review.
Hepple, P. ; Ford, N. ; McNerney, R. ;
Int J Tuberc Lung Dis, 2012; 16(5):579-88
Tuberculosis Diagnostics and Biomarkers: Needs, Challenges, Recent Advances, and Opportunities.
McNerney, R. ; Maeurer, M. ; Abubakar, I. ; Marais, B. ; McHugh, T.D. ; Ford, N. ; Weyer, K. ; Lawn, S. ; Grobusch, M.P. ; Memish, Z. ; Squire, S.B. ; Pantaleo, G. ; Chakaya, J. ; Casenghi, M. ; Migliori, G.B. ; Mwaba, P. ; Zijenah, L. ; Hoelscher, M. ; Cox, H. ; Swaminathan, S. ; Kim, P. ; Schito, M. ; Harari, A. ; Bates, M. ; Schwank, S. ; O'Grady, J. ; Pletschette, M. ; Ditui, L. ; Atun, R. ; Zumla, A. ;
J Infect Dis, 2012;
Towards a point-of-care test for active tuberculosis: obstacles and opportunities.
McNerney, R. ; Daley, P. ;
Nat Rev Microbiol, 2011; 9(3):204-13
Effectiveness of the Standard WHO Recommended Retreatment Regimen (Category II) for Tuberculosis in Kampala, Uganda: A Prospective Cohort Study.
Jones-López, E.C. ; Ayakaka, I. ; Levin, J. ; Reilly, N. ; Mumbowa, F. ; Dryden-Peterson, S. ; Nyakoojo, G. ; Fennelly, K. ; Temple, B. ; Nakubulwa, S. ; Joloba, M.L. ; Okwera, A. ; Eisenach, K.D. ; McNerney, R. ; Elliott, A.M. ; Ellner, J.J. ; Smith, P.G. ; Mugerwa, R.D. ;
PLoS Med, 2011; 8(3):e1000427
Propagation of respiratory aerosols by the vuvuzela.
Lai, K.M. ; Bottomley, C. ; McNerney, R. ;
PLoS One, 2011; 6(5):e20086
Tuberculosis in Sudan: a study of Mycobacterium tuberculosis strain genotype and susceptibility to anti-tuberculosis drugs.
Sharaf Eldin, G.S. ; Fadl-Elmula, I. ; Ali, M.S. ; Ali, A.B. ; Salih, A.L. ; Mallard, K. ; Bottomley, C. ; McNerney, R. ;
BMC Infect Dis, 2011; 11:219
Screening of immigrants in the UK for latent tuberculosis.
McNerney, R. ; Ferrara, G. ; O'Grady, J. ; Maeurer, M. ; Zumla, A. ;
Expert Rev Respir Med, 2011; 5(4):483-6
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