Dr Natasha Martin (nee Li)DPhil

Honorary Research Fellow

I am a posdoctoral researcher based in the Department of Social Medicine, University of Bristol and the Department of Global Health and Development, LSHTM. I am currently working with Professor Matthew Hickman and Dr. Peter Vickerman on mathematical models of hepatitis C spread amongst injecting drug users.  

I completed my DPhil in 2009 at the Centre for Mathematical Biology at Oxford University under the supervision of Professor Philip Maini and Dr. Eamonn Gaffney. My thesis focused on mathematical models of tumour acidity and invasion.  

Previously, during my undergraduate at Stanford University, I researched phenotypic plasticity of barnacle leg lengths with Professor Mark Denny and mathematical models of chronic myelogenous leukemia with Dr. Helen Moore.

Affiliation

Research

 Mathematical modelling applied to medicine and public health, Hepatitis C, HIV, injecting drug use, tumour acidity and invasion, cost-efficacy of public health interventions, and optimal resource allocation.

Publications:

2011

·    Vickerman, P., Martin, N.K., and Hickman, M. Understanding the trends in HIV and HCV prevalence amongst injecting drug users in different settings – implications for intervention impact. (submitted)

·    Vickerman P., Martin, N.K., and Hickman, M. Can needle and syringe programmes and opiate substitution therapy achieve substantial reductions in HCV prevalence? Model projections for different epidemic scenarios. (submitted)

·     Hellard, M., Jenkinson, R., Higgs, P., Stoove, M., Sacks-Davis R., Gold J., Hickman M., Vickerman P., and Martin, N.K. Modelling the utility of antiviral treatment for primary prevention of hepatitis C infection among people who inject drugs in Victoria, Australia. (submitted)

·   Martin, N.K.,  Robey, I.F., Gaffney, E.A., Gatenby, R.A., Gillies, R.J., and Maini, P.K.  Evaluating the Safety and Efficacy of Buffer Therapy: A Mutlidisciplinary Modelling Analysis. (submitted)

·   Martin, N.K., Vickerman, P., Miners, A., Foster, G.R., Hutchinson, S., Goldberg, D., and Hickman, M. 2011. The cost-effectiveness of HCV antiviral treatment for injecting drug user populations. Hepatology. (In press)

·   Martin, N.K., Pitcher, A.B., Vickerman, P., Vassall A., and Hickman, M. 2011. Optimal Control of Hepatitis C Antiviral Treatment Programme Delivery for Prevention Amongst a Population of Injecting Drug Users. PLoS ONE. 6(8):e22309.

·   Robey, I.F. and Martin, N.K. 2011. Bicarbonate and dichloroacetate: Evaluationg pH altering therapies in a mouse model for metastatic breast cancer. BMC Cancer. doi: 10.1186/1471-2407-11-235.

·   Martin, N.K., Vickerman, P., Foster, G.R., Hutchinson, S., Goldberg, D., and Hickman, M. 2011. Can Antiviral Therapy for Hepatitis C Reduce the Prevalence of HCV Among Injecting Drug User Populations? A Modelling Analysis of its Prevention Utility. Journal of Hepatology. 54(6):1137-44.

·  Martin, N.K., Vickerman, P., and Hickman, M. 2011. Mathematical Modelling of Hepatitis C Treatment for  Journal of Theoretical Biology. 274(1):58-66.

·  Martin, N.K., Gaffney, E.A., Gatenby, R.A., Gillies, R.J., Robey, I.F., and Maini, P.K.  2011. A Mathematical Model of Tumour and Blood pHe.  Mathematical Biosciences. 231(1):1-11.

· Vickerman, P, Martin, N.K., and Hickman, M. 2011. Can hepatitis C virus treatment be used as a prevention strategy? Additional model projections for Australia and elsewhere. Drug and Alcohol Dependence. 113(2-3):83-5.

 

2010 

·   Martin, N.K., Gaffney, E.A., Gatenby, R.A., and Maini, P.K.  2010. Tumour-stromal Interactions in Acid-Mediated Invasion: A Mathematical Model. Journal of Theoretical Biology. 267(3):461-470.

·  Martin, N.K., Gaffney, E.A., Gatenby, R.A., and Maini, P.K.  2010. Leaky Vessels as a Potential Source of Stromal Acidification in Tumours.  Journal of Theoretical Biology. 267(3):454-460.


2009

· Martin, N.K. 2009. Mathematical Models of Tumour Acidity: Buffer therapy and stromal effects. DPhil thesis.

  

2008

· Bellomo, N., Li, N.K., and Maini, P.K. 2008. On the Foundations of Cancer Modeling: Selected Topics, Speculations, and Perspectives. Mathematical Models and Methods in Applied Sciences. 18: 593-646.

2004

· Moore, H. and N.K. Li. 2004. A Mathematical Model for Chronic Myelogenous Leukemia and T Cell Interaction. Journal of Theoretical Biology. 227: 513-523.

· Li, N.K. and M.W. Denny. 2004. Limits to Phenotypic Plasticity: Flow Effects on Barnacle Feeding Appendages. Biological Bulletin. 206: 121-124.

Research areas

  • Economic evaluation
  • Infectious disease policy
  • Modelling

Disciplines

  • Epidemiology
  • Mathematics

Disease and Health Conditions

  • HIV/AIDS
  • Infectious disease
  • Sexually transmitted disease

Other interests

  • Hepatitis C
  • Injecting Drug Users
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