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Dr Daniela Manno

Clinical Assistant Professor

London School of Hygiene & Tropical Medicine
Keppel Street
London
WC1E 7HT
United Kingdom

I am a clinical epidemiologist with extensive research experience in infectious diseases and clinical trials. I am one of the investigators of the EBOVAC1 and EBOVAC3 projects, which comprise a set of clinical trials on a two-dose Ad26.ZEBOV, MVA-BN-Filo Ebola vaccine regimen. The findings of these trials provided important data on the safety and immunogenicity of this vaccine regimen and supported its marketing authorisations in the European Union in 2020 for Ebola virus disease (EVD) prophylaxis.

As part of the EBOVAC projects, we also conducted a serosurvey to estimate the prevalence of IgG antibodies to Ebola virus amongst individuals who never experienced symptomatic EVD in a population previously exposed to Ebola and a cohort study to evaluate the effect of malaria infection on the immune response to the Ad26.ZEBOV, MVA-BN-Filo vaccine regimen in adults and children.

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Teaching

I am one of the tutors of the modules 'Applying Public Health Principles in Developing Countries' (3198) and ‘Control of Sexually Transmitted Infections’ (3192).

Research

My main research interests focus on the conduct of clinical trials and other epidemiological studies in the field of infectious diseases and vaccines.

Research Area
Epidemiology
Clinical trials
Vaccines
Disease and Health Conditions
Ebola virus
Malaria
Country
Sierra Leone
Tanzania
Democratic Republic of the Congo
Region
Sub-Saharan Africa (all income levels)

Selected Publications

Developing a vaccine against Sudan virus disease.
MANNO, D;
2023
The Lancet. Infectious diseases
The Effect of Previous Exposure to Malaria Infection and Clinical Malaria Episodes on the Immune Response to the Two-Dose Ad26.ZEBOV, MVA-BN-Filo Ebola Vaccine Regimen.
MANNO, D; PATTERSON, C; Drammeh, A; TETTEH, K; KROMA, MT; Otieno, GT; Lawal, BJ; SOREMEKUN, S; AYIEKO, P; Gaddah, A; Kamara, AB; Baiden, F; AFOLABI, MO; Tindanbil, D; Owusu-Kyei, K; Ishola, D; Deen, GF; Keshinro, B; Njie, Y; Samai, M; Lowe, B; Robinson, C; Leigh, B; DRAKELEY, C; GREENWOOD, B; ... WATSON-JONES, D.
2023
Vaccines
Developing a vaccine against Marburg virus disease.
MANNO, D;
2023
Lancet (London, England)
Safety and immunogenicity of an Ad26.ZEBOV booster dose in children previously vaccinated with the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen: an open-label, non-randomised, phase 2 trial.
MANNO, D; Bangura, A; Baiden, F; Kamara, AB; AYIEKO, P; Kallon, J; Foster, J; Conteh, M; CONNOR, NE; Koroma, B; Njie, Y; Borboh, P; Keshinro, B; Lawal, BJ; KROMA, MT; Otieno, GT; Deen, AT; CHOI, EM-L; BALAMI, AD; Gaddah, A; McLean, C; Luhn, K; Adetola, HH; Deen, GF; Samai, M; ... WATSON-JONES, D.
2022
The Lancet. Infectious diseases
Ebola Virus Glycoprotein IgG Seroprevalence in Community Previously Affected by Ebola, Sierra Leone.
MANNO, D; AYIEKO, P; Ishola, D; AFOLABI, MO; Rogers, B; Baiden, F; Serry-Bangura, A; Bah, OM; Köhn, B; Swaray, I; Owusu-Kyei, K; Otieno, GT; Kowuor, D; Tindanbil, D; Smout, E; Robinson, C; Keshinro, B; Foster, J; GALLAGHER, K; Lowe, B; Douoguih, M; Leigh, B; GREENWOOD, B; WATSON-JONES, D;
2022
Emerging Infectious Diseases
Safety and immunogenicity of the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in children in Sierra Leone: a randomised, double-blind, controlled trial.
AFOLABI, MO; ISHOLA, D; MANNO, D; Keshinro, B; Bockstal, V; Rogers, B; Owusu-Kyei, K; Serry-Bangura, A; Swaray, I; Lowe, B; Kowuor, D; Baiden, F; Mooney, T; Smout, E; Köhn, B; Otieno, GT; Jusu, M; Foster, J; Samai, M; Deen, GF; LARSON, H; LEES, S; Goldstein, N; Gallagher, KE; Gaddah, A; ... EBL3001 study group,
2021
Lancet Infectious Diseases
HALT-IT--tranexamic acid for the treatment of gastrointestinal bleeding: study protocol for a randomised controlled trial.
ROBERTS, I; Coats, T; EDWARDS, P; Gilmore, I; Jairath, V; KER, K; MANNO, D; SHAKUR, H; Stanworth, S; Veitch, A;
2014
Trials
How effective is tranexamic acid for acute gastrointestinal bleeding?
MANNO, D; KER, K; ROBERTS, I;
2014
BMJ (Clinical research ed)
Reduced Poliovirus vaccine neutralising-antibody titres in infants with maternal HIV-exposure.
Sanz-Ramos, M; MANNO, D; Kapambwe, M; Ndumba, I; Musonda, KG; Bates, M; Chibumbya, J; Siame, J; Monze, M; FILTEAU, S; GOMPELS, UA; CIGNIS study team,;
2013
Vaccine
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