Dr Martin Llewellyn BA MA PhD
- Romm 329a
- LSHTM
- Keppel Street
- London
- WC1E 7HT
- T: +44 (0)207 927 2319
- F: +44 (0)2076368739
2003-2008: Ph.D. LSHTM "The molecular epidemiology of Trypanosoma cruzi infection in wild and domestic transmission cycles, with special emphasis on multilocus microsatellite analysis"
2009 - Present: Assistant Coordinator, ChagasEpiNet, EC FP7 Consortium, 15 International Partners
Affiliation
Teaching
Module Organiser - M3333 (Core Molecular Biology)
Lecturer - Molecular Biology: Research Progress and Applications
Course Tutor - MSc Control of Infectious Disease
Research
My current research focus is the population genetic diversity of Trypanosoma cruzi, causative agent of American trypansomiasis. Detailed epidemiological hypotheses can now be addressed in natural populations of this parasite using sequence and STR loci developed from the genome sequence. Practically these findings are of value in designing effective intervention strategies to prevent human disease. From a basic science perspective, these data also provide insight to the parasite‟s reproductive strategy, mode of silvatic (wild) transmission, and evolutionary history in South America.In parallel, I participate in the devopment of new diagnostics for Chagas disease, comparative genomics and sequencing / assembly of new T. cruzi genomes, and coordination of field resarch in Latin America in collaboration with overseas partners.
Research areas
- Trypanosomes
Disciplines
- Epidemiology
- Genetics
- Genomics
- Molecular epidemiology
- Parasitology
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Selected publications
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Extraordinary Trypanosoma cruzi diversity within single mammalian reservoir hosts implies a mechanism of diversifying selection.
Llewellyn, M.S.; Rivett-Carnac, J.B.; Fitzpatrick, S.; Lewis, M.D.; Yeo, M.; Gaunt, M.W.; Miles, M.A.;
Int J Parasitol, 2011;
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Shotgun sequencing analysis of Trypanosoma cruzi I Sylvio X10/1 and comparison with T. cruzi VI CL Brener.
Franzén, O. ; Ochaya, S. ; Sherwood, E. ; Lewis, M.D. ; Llewellyn, M.S. ; Miles, M.A. ; Andersson, B. ;
PLoS Negl Trop Dis, 2011; 5(3):e984
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Sex, Subdivision, and Domestic Dispersal of Trypanosoma cruzi Lineage I in Southern Ecuador
Ocana-Mayorga, S.; Llewellyn, M.S.; Costales, J.A.; Miles, M.A.; Grijalva, M.J.
Plos Neglected Tropical Diseases, 2010; 4(12)
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Flow cytometric analysis and microsatellite genotyping reveal extensive DNA content variation in Trypanosoma cruzi populations and expose contrasts between natural and experimental hybrids.
Lewis, M.D.; Llewellyn, M.S.; Gaunt, M.W.; Yeo, M.; Carrasco, H.J.; Miles, M.A.;
Int J Parasitol, 2009; 39(12):1305-17
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Genome-scale multilocus microsatellite typing of Trypanosoma cruzi discrete typing unit I reveals phylogeographic structure and specific genotypes linked to human infection.
Llewellyn, M.S.; Miles, M.A.; Carrasco, H.J.; Lewis, M.D.; Yeo, M.; Vargas, J.; Torrico, F.; Diosque, P.; Valente, V.; Valente, S.A.; Gaunt, M.W.;
PLoS Pathog, 2009; 5(5):e1000410
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Trypanosoma cruzi IIc: Phylogenetic and Phylogeographic Insights from Sequence and Microsatellite Analysis and Potential Impact on Emergent Chagas Disease.
Llewellyn, M.S.; Lewis, M.D.; Acosta, N.; Yeo, M.; Carrasco, H.J.; Segovia, M.; Vargas, J.; Torrico, F.; Miles, M.A.; Gaunt, M.W.;
PLoS Negl Trop Dis, 2009; 3(9):e510
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Origins of Chagas disease: Didelphis species are natural hosts of Trypanosoma cruzi I and armadillos hosts of Trypanosoma cruzi II, including hybrids.
Yeo, M.; Acosta, N.; Llewellyn, M.; Sanchez, H.; Adamson, S.; Miles, G.A.; Lopez, E.; Gonzalez, N.; Patterson, J.S.; Gaunt, M.W.; Arias, A.R.; Miles, M.A.;
Int J Parasitol, 2005; 35(2):225-33
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Ecological constraints on diversification in a model adaptive radiation
Kassen, R.; Llewellyn, M.; Rainey, P.B.
Nature, 2004; 431(7011):984-988
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