Dr Michael Lewis BSc MSc PhD

Research Assistant

• Affiliation
• Teaching
• Research
• Publications

• Room 331b
• LSHTM
• Keppel Street
• London
• WC1E 7HT
• T: 02079272814

I studied Genetics at Nottingham University, graduating in 2002. I was funded by the Leukaemia Research Fund to work as a summer project student investigating DNA repair genes associated with acute myeloblastic leukaemia and also worked in Nottingham City Hospital histopathology laboratory. I obtained an MSc in Medical Molecular Microbiology in 2004, also at Nottingham.

I joined the School in 2004 to work in Michael Miles' laboratory on the genetics of hybridisation in Trypanosoma cruzi. I completed my PhD in 2008 and continued to work on T. cruzi, focusing on molecular epidemiology and recombination in natural and experimental settings.

In 2011 I joined John Kelly's laboratory to work on development of in vivo models of Chagas disease.

Affiliation

• Department of Pathogen Molecular Biology

Teaching

I am the organiser for module 3160 "Molecular Biology: Research Progress and Applications". I teach on this module as well as the core molecular biology course.

Research

Experimental models of Chagas disease

Evolution and molecular epidemiology of trypanosomatids

• Selected publications

• Identification and lineage genotyping of South American trypanosomes using fluorescent fragment length barcoding

  Hamilton, P.B.; Lewis, M.D.; Cruickshank, C.; Gaunt, M.W.; Yeo, M.; Llewellyn, M.S.; Valente, S.A.; da Silva, F.M.; Stevens, J.R.; Miles, M.A.; Teixeira, M.M.G.

  Infection Genetics and Evolution, 2011; 11(1):44-51

• Shotgun sequencing analysis of Trypanosoma cruzi I Sylvio X10/1 and comparison with T. cruzi VI CL Brener.

  Franzén, O. ; Ochaya, S. ; Sherwood, E. ; Lewis, M.D. ; Llewellyn, M.S. ; Miles, M.A. ; Andersson, B. ;

  PLoS Negl Trop Dis, 2011; 5(3):e984

• Visualisation of Leishmania donovani Fluorescent Hybrids during Early Stage Development in the Sand Fly Vector

  Sadlova, J.; Yeo, M.; Seblova, V.; Lewis, M.D.; Mauricio, I.; Volf, P.; Miles, M.A.

  Plos One, 2011; 6(5)

• Recent, Independent and Anthropogenic Origins of Trypanosoma cruzi Hybrids.

  Lewis, M.D. ; Llewellyn, M.S. ; Yeo, M. ; Acosta, N. ; Gaunt, M.W. ; Miles, M.A. ;

  PLoS Negl Trop Dis, 2011; 5(10):e1363

• Flow cytometric analysis and microsatellite genotyping reveal extensive DNA content variation in Trypanosoma cruzi populations and expose contrasts between natural and experimental hybrids.

  Lewis, M.D.; Llewellyn, M.S.; Gaunt, M.W.; Yeo, M.; Carrasco, H.J.; Miles, M.A.;

  Int J Parasitol, 2009; 39(12):1305-17

• Genome-scale multilocus microsatellite typing of Trypanosoma cruzi discrete typing unit I reveals phylogeographic structure and specific genotypes linked to human infection.

  Llewellyn, M.S.; Miles, M.A.; Carrasco, H.J.; Lewis, M.D.; Yeo, M.; Vargas, J.; Torrico, F.; Diosque, P.; Valente, V.; Valente, S.A.; Gaunt, M.W.;

  PLoS Pathog, 2009; 5(5):e1000410

• Trypanosoma cruzi IIc: Phylogenetic and Phylogeographic Insights from Sequence and Microsatellite Analysis and Potential Impact on Emergent Chagas Disease.

  Llewellyn, M.S.; Lewis, M.D.; Acosta, N.; Yeo, M.; Carrasco, H.J.; Segovia, M.; Vargas, J.; Torrico, F.; Miles, M.A.; Gaunt, M.W.;

  PLoS Negl Trop Dis, 2009; 3(9):e510

• Genotyping of Trypanosoma cruzi: systematic selection of assays allowing rapid and accurate discrimination of all known lineages.

  Lewis, M.D.; Ma, J.; Yeo, M.; Carrasco, H.J.; Llewellyn, M.S.; Miles, M.A.;

  Am J Trop Med Hyg, 2009; 81(6):1041-9

• → View all Dr Michael Lewis's publications

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