Taemi Kawahara BSc PhD PGDip
- Room 180
- LSHTM
- Keppel Street
- London
- WC1E 7HT
- T: +44(0)207 958 8121
- F: +44(0)20 7299 4663
After obtaining a degree in Biological Sciences from Sussex University I joined LSHTM to do a PhD supervised by Dr David Horn, investigating the control of gene expression in African trypanosomes. I took up my current post as Assistant Trial Manager in the Clinical Trials Unit in September 2007.
Affiliation
Teaching
Over the past 2 years I have worked as a tutor on the Distance Learning MSc Clinical Trials (http://www.lshtm.ac.uk/prospectus/masters/dmsct.html).
Research
I work in group that is interested in improving outcomes for patients in emergency bleeding conditions.
Currently I am working on the WOMAN Trial which aims to assess the effect of an antifibrinolytic (tranexamic acid) as a treatment for postpartum haemorrhage (http://www.womantrial.lshtm.ac.uk/).
Previously I have worked on the CRASH-2 trial (Clinical Randomisation of an Anti-fibrinolytic in Significant Haemorrhage), the CRASH2 Intracranial Bleeding Study and the BRAIN Trial (Bradykinin B2 Receptor Antagonist in Neurotrauma).
Research areas
- Clinical trials
- Critical care
- Maternal health
Disease and Health Conditions
- Injuries
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Selected publications
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Effect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study).
CRASH-2 Collaborators (Intracranial Bleeding Study) inc. Perel, P; Kawahara, T; Roberts, I; Shakur, H;
BMJ, 2011; 343:d3795
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RNA interference, growth and differentiation appear normal in African trypanosomes lacking Tudor staphylococcal nuclease.
Alsford, S.; Kemp, L.E.; Kawahara, T.; Horn, D.;
Mol Biochem Parasitol, 2010;
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Histone deacetylases play distinct roles in telomeric VSG expression site silencing in African trypanosomes.
Wang, Q.P.; Kawahara, T.; Horn, D.;
Mol Microbiol, 2010;
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Acetylation of histone H4K4 is cell cycle regulated and mediated by HAD in Trypanosoma brucei
Siegel, T.N.; Kawahara, T.; Degrasse, J.A.; Janzen, C.J.; Horn, D.; Cross, G.A.M.
Molecular Microbiology, 2008; 67(4):762-771
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Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes.
Kawahara, T.; Siegel, T.N.; Ingram, A.K.; Alsford, S.; Cross, G.A.; Horn, D.;
Mol Microbiol, 2008; 69(4):1054-68
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A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation.
Alsford, S.; Kawahara, T.; Isamah, C.; Horn, D.;
Mol Microbiol, 2007; 63(3):724-36
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Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effects.
Alsford, S.; Kawahara, T.; Glover, L.; Horn, D.;
Mol Biochem Parasitol, 2005; 144(2):142-8
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