Dr Harparkash Kaur BSc PhD CSci CChem FRSC

Lecturer of Pharmacology

• Affiliation
• Teaching
• Research
• Research areas
• Disciplines
• Publications

• Room 493
• LSHTM
• Keppel Street
• London
• WC1E 7HT
• T: +44(0)20 7299 4629 (office)
• F: 0207 299 4720

 

I gained both the BSc and PhD in Chemistry from the University of London. My research career began with the synthesis of compounds called spin traps to study reactions postulated to involve the participation of free radicals. I subsequently moved on to applying laboratory based analytical techniques such as high performance liquid chromatography (HPLC) to study biological systems whilst working on drug development for the treatment of surface cancerous tumours. I have developed HPLC based methods for use in varying fields of research including determining the levels of free radicals (mainly the hydroxyl and nitric oxide) in disease state (rheumatoid arthritis, ischemic reperfusion injury, cancer etc) and levels of endogenous antioxidants. Most recently I have been developing/applying laboratory and field friendly analytical techniques as tools to check the quality and, levels of drugs and amounts of insecticides on bed nets in the fight against malaria.

Elected chartered chemist, fellow of the Royal Society of Chemistry in 1999 (CChem FRSC) and designated a chartered scientist (CSci) in 2005.

I joined the research staff of the Gates Malaria Partnership at LSHTM in 2001, and am a member of the newly-formed Artemisinin Combination Therapy Consortium (www.actconsortium.org).

Affiliation

• Department of Clinical Research
• Department of Disease Control

Teaching

• Organiser of the Masters Module "Control and Epidemiology of Malaria".
• Supervision of MSc projects and practical teaching of chromatographic techniques on Antimicrobial Chemotherapy Study Module.
• Teaching on both of the above mentioned Study Modules.

Research

Running the liquid chromatography/ mass spectrometry facility to study levels, pharmacokinetics, novel metabolites and quality of antimalarial drugs as well as amounts of insecticides on bednets. Have developed field and user- friendly methods (using two different reagents) using thin layer chromatography plates for the specific and sensitive detection of the artemisinin derivatives exclusively in tablets (LSHTM patent pending). Also developed a rapid test for the detection of insecticides on bed nets and compliance of indoor residual spraying (LSHTM patent pending).

I am the principal investigator on the project to assess the quality of drugs in Africa, which is funded by the Artemisinin Combination Therapy Consortium, via an award to LSHTM by the Bill and Melinda Gates Foundation.

• Selected publications

• Antimalarial drug quality: methods to detect suspect drugs

  Kaur, H.; Green, M.D.; Hostetler, D.M.; Fern; Ndez, F.M.; Newton, P.N.

  Therapy, 2010; 7:49-57

• Quality of anti-malarial drugs provided by public and private healthcare providers in south-east Nigeria

  Onwujekwe, O.; Kaur, H.; Dike, N.; Shu, E.; Uzochukwu, B.; Hanson, K.; Okoye, V.; Okonkwo, P.

  Malaria Journal, 2009; 8

• Simple field assays to check quality of current artemisinin-based antimalarial combination formulations

  Ioset, J.R.; Kaur, H.

  PLoS One, 2009; 4(9):e7270

• Epidemic of Plasmodium falciparum malaria involving substandard antimalarial drugs, Pakistan, 2003.

  Leslie, T.; Kaur, H.; Mohammed, N.; Kolaczinski, K.; Ord, R.L.; Rowland, M.;

  Emerg Infect Dis, 2009; 15(11):1753-9

• COLORIMETRIC ASSAY FOR PYRETHROID INSECTICIDES

  Kaur, H; Eggelte, T

  UK Intellectual Property Office, 2009; WO 2009106845(A1)

• Validation of spermidine synthase as a drug target in African trypanosomes.

  Taylor, M.C.; Kaur, H.; Blessington, B.; Kelly, J.M.; Wilkinson, S.R.;

  Biochem J, 2008; 409(2):563-9

• A nationwide survey of the quality of antimalarials in retail outlets in Tanzania.

  Kaur, H.; Goodman, C.; Thompson, E.; Thompson, K.A.; Masanja, I.; Kachur, S.P.; Abdulla, S.;

  PLoS ONE, 2008; 3(10):e3403

• ASSAY, KIT AND APPARATUS FOR DETECTION OF ARTEMISININ DERIVATIVES

  Kaur, H.; Ioset, J.-R.

  UK Intellectual Property Office, 2007; WO2007077444(A1)

• → View all Dr Harparkash Kaur's publications

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