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Ms Shiromani Jayawardhana

Scientific Officer

United Kingdom

Affiliations

Department of Infection Biology
Faculty of Infectious and Tropical Diseases

Selected Publications

Assessing the Effectiveness of Curative Benznidazole Treatment in Preventing Chronic Cardiac Pathology in Experimental Models of Chagas Disease.
FRANCISCO, AF; JAYAWARDHANA, S; TAYLOR, MC; LEWIS, MD; KELLY, JM;
2018
Antimicrobial agents and chemotherapy
Imaging the development of chronic Chagas disease after oral transmission.
LEWIS, MD; FRANCISCO, AF; JAYAWARDHANA, S; Langston, H; TAYLOR, MC; KELLY, JM;
2018
Scientific reports
Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping.
Costa, FC; FRANCISCO, AF; JAYAWARDHANA, S; Calderano, SG; LEWIS, MD; Olmo, F; Beneke, T; Gluenz, E; Sunter, J; Dean, S; KELLY, JM; TAYLOR, MC;
2018
PLoS neglected tropical diseases
Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi.
Brand, S; Ko, EJ; Viayna, E; Thompson, S; Spinks, D; Thomas, M; Sandberg, L; FRANCISCO, AF; JAYAWARDHANA, S; SMITH, VC; Jansen, C; De Rycker, M; Thomas, J; MacLean, L; Osuna-Cabello, M; Riley, J; Scullion, P; Stojanovski, L; Simeons, FR C; Epemolu, O; Shishikura, Y; Crouch, SD; Bakshi, TS; Nixon, CJ; Reid, IH; ... Gilbert, IH.
2017
Journal of medicinal chemistry
Biological factors that impinge on Chagas disease drug development.
FRANCISCO, AF; JAYAWARDHANA, S; LEWIS, MD; TAYLOR, MC; KELLY, JM;
2017
Parasitology
Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage.
FRANCISCO, AF; JAYAWARDHANA, S; LEWIS, MD; White, KL; Shackleford, DM; Chen, G; Saunders, J; Osuna-Cabello, M; Read, KD; Charman, SA; Chatelain, E; KELLY, JM;
2016
Scientific reports
Insertion of Isocyanides into N-Si Bonds: Multicomponent Reactions with Azines Leading to Potent Antiparasitic Compounds.
Kishore, KG; Ghashghaei, O; Estarellas, C; Mestre, MM; Monturiol, C; Kielland, N; KELLY, JM; FRANCISCO, AF; JAYAWARDHANA, S; Muñoz-Torrero, D; Pérez, B; Luque, FJ; Gámez-Montaño, R; Lavilla, R;
2016
Angewandte Chemie
Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathy.
LEWIS, MD; FRANCISCO, AF; TAYLOR, MC; JAYAWARDHANA, S; KELLY, JM;
2016
Cellular microbiology
Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging.
FRANCISCO, AF; LEWIS, MD; JAYAWARDHANA, S; TAYLOR, MC; Chatelain, E; KELLY, JM;
2015
Antimicrobial agents and chemotherapy
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