Dr David Horn BSc PhD
- 382
- LSHTM
- Keppel Street
- London
- WC1E 7HT
- T: +44 (0) 20 7927 2352
- F: +44 (0) 20 7636 8739
David Horn obtained his PhD from University College London (1989-1993). Following postdoctoral work with Prof. George Cross at the Rockefeller University in New York (1993-1997), he joined the department of ITD (1997-present). The groups research on African trypanosomes focuses on molecular mechanism underlying antigenic variation and drug resistance.
Current projects include studies on:
- Histone acetylation - roles in gene expression and antigenic variation.
- DNA repair - roles in antigenic variation.
- Telomeres/chromosome ends - roles in antigenic variation.
- High-throughput RNA interference technologies
- Drug-resistance mechanisms.
See Lab-pages for further details.
Affiliation
Teaching
Among other roles, Module organiser: Advanced Training in Molecular Biology.
Research
See 'Background' above.
Research areas
- Genomics
- Trypanosomes
Disciplines
- Cell biology
- Molecular biology
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Selected publications
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Elongator Protein 3b Negatively Regulates Ribosomal DNA Transcription in African Trypanosomes.
Alsford, S. ; Horn, D. ;
Mol Cell Biol, 2011;
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High throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome.
Alsford, S. ; Turner, D. ; Obado, S. ; Sanchez-Flores, A. ; Glover, L. ; Berriman, M. ; Hertz-Fowler, C. ; Horn, D. ;
Genome Res, 2011;
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Molecular mechanisms underlying the control of antigenic variation in African trypanosomes.
Horn, D.; McCulloch, R.;
Curr Opin Microbiol, 2010;
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Microhomology-mediated deletion and gene conversion in African trypanosomes.
Glover, L.; Jun, J.; Horn, D.;
Nucleic Acids Res, 2010;
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Sequence homology and microhomology dominate chromosomal double-strand break repair in African trypanosomes.
Glover, L.; McCulloch, R.; Horn, D.;
Nucleic Acids Res, 2008; 36(8):2608-18
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Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes.
Kawahara, T.; Siegel, T.N.; Ingram, A.K.; Alsford, S.; Cross, G.A.; Horn, D.;
Mol Microbiol, 2008; 69(4):1054-68
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Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest.
Glover, L.; Alsford, S.; Beattie, C.; Horn, D.;
Nucleic Acids Res, 2007; 35(3):872-80
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Repression of polymerase I-mediated gene expression at Trypanosoma brucei telomeres.
Glover, L.; Horn, D.;
EMBO Rep, 2006; 7(1):93-9
- → View all Dr David Horn's publications
