Rachel Hallett BSc PhD

Lecturer

• Affiliation
• Teaching
• Research
• Publications

• 
• Room 315
• LSHTM
• Keppel Street
• London
• WC1E 7HT
• T: +44 (0)20 7927 2333

Graduated with a degree in Biology with Industrial Experience from University of Manchester and moved to London to work at the Health Protection Agency Centre for Infections, Colindale, in the Virus Reference Department. Registered on a part-time PhD with University College London (UCL) and completed a thesis on the molecular epidemiology of bloodborne hepatitis viruses in 2001. Joined the Department of Infectious and Tropical Diseases at LSHTM in 2002 to work with Dr Colin Sutherland on a Gates Malaria Partnership project to examine the effects of combination therapy on post-treatment carriage and transmission of drug resistance genes in Plasmodium falciparum malaria parasites. Second post-doctoral position at UCL, working on a large clinical trial to measure the impact on mortality of screening postmenopausal women for ovarian cancer. Re-joined LSHTM in September 2008 to continue genetic studies of drug resistance in Plasmodium falciparum as part of an EU-FP7 consortium grant, MALACTRES.

Affiliation

• Immunology and Infection Department

Teaching

• Tutor for MSc Medical Parasitology
• Tutor for Distance Learning MSc Infectious Diseases (malaria module)
• Project supervisor for MSc summer laboratory-based projects

Research

• Molecular epidemiology of Plasmodium falciparum malaria, particularly with respect to molecular markers of antimalarial drug resistance.

Lab work includes:

• In vivo approaches to the validation of candidate molecular markers of artemisinin combination therapy (ACT) resistance.
• Study of enhanced gametocytaemia and transmission to mosquitoes of drug resistant malaria parasites.
• Development of molecular assays for mutation detection and relative quantitation of RNA/DNA.

• Selected publications

• Efficacy of amodiaquine, sulphadoxine-pyrimethamine and their combination for the treatment of uncomplicated Plasmodium falciparum malaria in children in Cameroon at the time of policy change to artemisinin-based combination therapy

  Mbacham, W.F.; Evehe, M.S.B.; Netongo, P.M.; Ateh, I.A.; Mimche, P.N.; Ajua, A.; Nji, A.M.; Irenee, D.; Echouffo-Tcheugui, J.B.; Tawe, B.; Hallett, R.; Roper, C.; Targett, G.; Greenwood, B.

  Malaria Journal, 2010; 9

• Amodiaquine resistance in Plasmodium falciparum malaria is associated with the pfcrt 72-76 SVMNT allele in Afghanistan.

  Beshir, K.; Sutherland, C.J.; Merinopoulos, I.; Durrani, N.; Leslie, T.; Rowland, M.; Hallett, R.L.;

  Antimicrob Agents Chemother, 2010;

• Measuring the efficacy of anti-malarial drugs in vivo: quantitative PCR measurement of parasite clearance.

  Beshir, K.B.; Hallett, R.L.; Eziefula, A.C.; Bailey, R.; Watson, J.; Wright, S.G.; Chiodini, P.L.; Polley, S.D.; Sutherland, C.J.;

  Malar J, 2010; 9(1):312

• Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)

  Menon, U.; Gentry-Maharaj, A.; Hallett, R.; Ryan, A.; Burnell, M.; Sharma, A.; Lewis, S.; Davies, S.; Philpott, S.; Lopes, A.; Godfrey, K.; Oram, D.; Herod, J.; Williamson, K.; Seif, M.W.; Scott, I.; Mould, T.; Woolas, R.; Murdoch, J.; Dobbs, S.; Amso, N.N.; Leeson, S.; Cruickshank, D.; McGuire, A.; Campbell, S.; Fallowfield, L.; Singh, N.; Dawnay, A.; Skates, S.J.; Parmar, M.; Jacobs, I.

  Lancet Oncol, 2009; 10(4):327-40

• A trial of the efficacy, safety and impact on drug resistance of four drug regimens for seasonal intermittent preventive treatment for malaria in Senegalese children.

  Sokhna, C.; Cisse, B.; Bâ, e.l. .H.; Milligan, P.; Hallett, R.; Sutherland, C.; Gaye, O.; Boulanger, D.; Simondon, K.; Simondon, F.; Targett, G.; Lines, J.; Greenwood, B.; Trape, J.F.;

  PLoS ONE, 2008; 3(1):e1471

• Recruitment to multicentre trials--lessons from UKCTOCS: descriptive study.

  Menon, U.; Gentry-Maharaj, A.; Ryan, A.; Sharma, A.; Burnell, M.; Hallett, R.; Lewis, S.; Lopez, A.; Godfrey, K.; Oram, D.; Herod, J.; Williamson, K.; Seif, M.; Scott, I.; Mould, T.; Woolas, R.; Murdoch, J.; Dobbs, S.; Amso, N.; Leeson, S.; Cruickshank, D.; McGuire, A.; Campbell, S.; Fallowfield, L.; Skates, S.; Parmar, M.; Jacobs, I.;

  BMJ, 2008; 337:a2079

• Amodiaquine and Artemether-Lumefantrine Select Distinct Alleles of the Plasmodium falciparum mdr1 Gene in Tanzanian Children Treated for Uncomplicated Malaria.

  Humphreys, G.S.; Merinopoulos, I.; Ahmed, J.; Whitty, C.J.; Mutabingwa, T.K.; Sutherland, C.J.; Hallett, R.L.;

  Antimicrob Agents Chemother, 2007; 51(3):991-7

• Seasonal Carriage of pfcrt and pfmdr1 Alleles in Gambian Plasmodium falciparum Imply Reduced Fitness of Chloroquine-Resistant Parasites.

  Ord, R.; Alexander, N.; Dunyo, S.; Hallett, R.; Jawara, M.; Targett, G.; Drakeley, C.J.; Sutherland, C.J.;

  J Infect Dis, 2007; 196(11):1613-1619

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