Dr Ozan Gundogdu BSc MSc PhD
- 380
- LSHTM
- Keppel Street
- London
- WC1E 7HT
- T: 02079588383
Ozan Gundogdu joined the school in 2004 and holds the position of Bioinformatics/Genomics Research Technician. Before joining the school he completed a BSc Honours in Molecular Biology followed by an MSc Computer Science (Commendation), both at the University of Hertfordshire. His undergraduate also contained an industrial placement year which was completed at RAFT - Institute of Plastic Surgery, where he was research assistant in the Molecular Biology group. During his time at the LSHTM, Ozan completed a PhD studying the microbial pathogenesis of the bacterial pathogen Campylobacter jejuni.
Affiliation
Teaching
Ozan lectures on "Molecular Biology" (3333) and "Molecular Biology Research Progress & Applications" (3160) modules as part of the MBID and Medical Microbiology MSc courses. He acts as a tutor for students on the Medical Microbiology MSc course and also co-superviser of MSc students with projects involving a laboratory or bioinformatics theme. He gives laboratory demonstrations on microarray techniques and faculty equipment to MSc students. He also acts as an exam invigilator. In addition, he teaches internal and external researchers about a number of faculty equipment and also data analysis techniques.
Along with teaching, Ozan has two other aspects of work at the school; technical and research. The technical side involves being responsible for the running and maintenance of a number of faculty equipment e.g. Affymetrix system, ABI3730 sequencer and microarray analysis software such as GeneSpring. He is in charge of teaching, costs, documentation and acts as a point of call for any relating issues.
Research
Current research interests include the study of C. jejuni bacterial pathogenesis using a number of mutants. Topics of interest include;
- Identification and characterisation of virulence genes
- Mechanisms of C. jejuni response to environmental and host stress
- C. jejuni mutants affecting motility
- Investigation of host-pathogen interactions
Ozan has also completed the full re-annotation of the C. jejuni NCTC11168 genome (in collaboration with the Sanger Institute) and has created and runs the Campylobacter Resource Facility (CRF) website.
In addition to the above, Ozan has linked to a number of other internal and external projects which include a next-generation sequencing/bioinformatics theme e.g. Sanitation Ventures. He has and still is involved in multiple microarray data analysis projects and is actively involved in teaching and enhancing the school's microarray/bioinformatics software tools. Ozan is responsible for running and maintaining the Genome Resource Facility within the Pathogen Molecular Biology department and has created and runs the Genome Resource Facility (GRF) website.
Research areas
- Bacteria
- Genomics
- Innate immunity
- Molecular epidemiology
Disciplines
- Molecular biology
- Pathology
Other interests
- Bioinformatics
- Microarrays
- Microbial Pathogenicity
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Selected publications
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The Campylobacter jejuni transcriptional regulator Cj1556 plays a role in the oxidative and aerobic (O2) stress response and is important for bacterial survival in vivo.
Gundogdu, O. ; Mills, D.C. ; Elmi, A. ; Martin, M.J. ; Wren, B.W. ; Dorrell, N. ;
J Bacteriol, 2011;
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Post-genome Analysis of the Foodborne Pathogen Campylobacter jejuni
Kay, E.; Gundogdu, O.; Wren, B.
in 'Genomics of Foodborne Bacterial Pathogens' M. Wiedmann and W. Zhang(2011) Springer (Heidelberg) :55-9
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Administration of Capsule-Selective Endosialidase E Minimises Up-Regulation of Organ Gene Expression Induced by Experimental Systemic Infection with Escherichia coli K1.
Zelmer, A.; Martin, M.; Gundogdu, O.; Birchenough, G.; Lever, R.; Wren, B.W.; Luzio, J.P.; Taylor, P.W.;
Microbiology, 2010;
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Campylobacter jejuni alters surface capsular polysaccharide when co-cultured with epithelial cells.
Corcionivoschi, N.; Clyne, M.; Lyons, A.; Elmi, A.; Gundogdu, O.; Wren, B.W.; Dorrell, N.; Karlyshev, A.V.; Bourke, B.;
Infect Immun, 2009; 77(5):1959-67
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Re-annotation and re-analysis of the Campylobacter jejuni NCTC11168 genome sequence.
Gundogdu, O.; Bentley, S.D.; Holden, M.T.; Parkhill, J.; Dorrell, N.; Wren, B.W.;
BMC Genomics, 2007; 8:162
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Inactivation of cmeF in Campylobacter jejuni is Associated with filamentation
Ghori, S.; Elmi, A.; Gundogdu, O.; Dorrell, N.; Eaves, D.J.; Ricci, V.; Penn, C.W.; Piddock, L.J.V.
Zoonoses and Public Health, 2007; 54:106-107
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Comparative phylogenomics of the food-borne pathogen Campylobacter jejuni reveals genetic markers predictive of infection source.
Champion, O.L.; Gaunt, M.W.; Gundogdu, O.; Elmi, A.; Witney, A.A.; Hinds, J.; Dorrell, N.; Wren, B.W.;
Proc Natl Acad Sci U S A, 2005; 102(44):16043-8
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Improved production by domain inversion of single-chain Fv antibody fragment against high molecular weight proteoglycan for the radioimmunotargeting of melanoma.
Hamilton, S.; Odili, J.; Gundogdu, O.; Wilson, G.D.; Kupsch, J.M.;
Hybrid Hybridomics, 2001; 20(5-6):351-60
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