Professor Richard Grieve BA MSc PhD
- Richard Grieve's Contacts
- Room 144
- 15-17 Tavistock Place
- WC1H 9SH
- T: 020 7927 2255
- F: 020 7927 2701
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I lead a research team whose current research focuses on developing quantitative methods for health economic evaluation. Our expertise is in the design and analysis of health economic evalautions that use RCTs and observational data. We are developing methods that address common methodological issues such as non-compliance, missing data, confounding due to treatment selection, and external validity.
We also undertake applied health economic evaluations predominately in the areas of adult and paediatric intensive care, emergency medicine, elective surger, and to the evaluation of new health policies. We have recently started an evaluation of the integrated care pioneers.
My research programme is funded by a five year senior research fellowship from NIHR.
I teach on the introductory module, introduction to health economics, and organise the economic evaluation module
My main research interests are in developing analytical methods for cost-effectiveness analyses. My current work aims to develop more appropriate analytical methods for dealing with selection bias, missing data and clustered data.
I was the PI for a 3 year ESRC project on methods for reducing selection bias in health economic evaluation. The study considered alternative approaches for addressing imbalances in observed covariates. In particular, the study examined Genetic Matching, an automated matching approach that extends traditional propensity score matching. The study involved close collaboration with colleagues at the University of California at Berkeley.
I was also the PI on a 3.5 year MRC funded project to investigate analytical methods for economic evaluations that use data from cluster randomised trials. This work compared multilevel models to robust variance estimators and bootstrap procedures. The project was in collaboration with colleagues at the University of Cambridge and in the Department of Medical Statistics, LSHTM. Recent extensions to this project involved methods for handling missing data in hierarchical settings
I have ongoing interests in applying the techniques of economic evaluation across a diverse range of clinical areas including adult and paediatric intensive care, hepatitis C, mental health, and for routine surgical procedures.
I am interested in supervising PhD students in the general area of statistical methods and health economic evaluation.
- Economic evaluation
- Health policy
- Health technology assessment
- Statistical methods
Disease and Health Conditions
- Cardiovascular disease
- Causal Inference
- Clustered Data
- Missing Data
- Multi Centre Studies
- Statistical methodology
- economics of health care
Multiple imputation methods for bivariate outcomes in cluster randomised trials.
DiazOrdaz, K.; Kenward, M.G.; Gomes, M.; Grieve, R.;
Stat Med, 2016; 35(20):3482-96
Trial of Early, Goal-Directed Resuscitation for Septic Shock.
Mouncey, P.R.; Osborn, T.M.; Power, G.S.; Harrison, D.A.; Sadique, M.Z.; Grieve, R.D.; Jahan, R.; Harvey, S.E.; Bell, D.; Bion, J.F.; Coats, T.J.; Singer, M.; Young, J.D.; Rowan, K.M.; ProMISe Trial Investigators, .;
N Engl J Med, 2015; 372(14):1301-11
Endovascular strategy or open repair for ruptured abdominal aortic aneurysm: one-year outcomes from the IMPROVE randomized trial.
IMPROVE Trial Investigators, .; COLLABORATORS;Braithwaite, B. ; Cheshire, N.J. ; Greenhalgh, R.M. ; Grieve, R. ; Hassan, T.B. ; Hinchliffe, R. ; Howell, S. ; Moore, F. ; Nicholson, A.A. ; Soong, C.V. ; Thompson, M.M. ; Thompson, S.G. ; Ulug, P. ; Heatley, F. ; Anjum, A. ; Kalinowska, G. ; Sweeting, M.J. ; Thompson, S.G. ; Gomes, M. ; Grieve, R. ; Powell, J.T. ; Ashleigh, R. ; Gomes, M. ; Greenhalgh, R.M. ; Grieve, R. ; Hinchliffe, R. ; Sweeting, M. ; Thompson, M.M. ; Thompson, S.G. ; Ulug, P. ; Roberts, I. ; Bell, P.R. ; Cheetham, A. ; Stephany, J. ; Warlow, C. ; Lamont, P. ; Moss, J. ; Tijssen, J. ; Braithwaite, B. ; Nicholson, A.A. ; Thompson, M. ; Ashleigh, R. ; Thompson, L. ; Cheshire, N.J. ; Boyle, J.R. ; Serracino-Inglott, F. ; Thompson, M.M. ; Hinchliffe, R.J. ; Bell, R. ; Wilson, N. ; Bown, M. ; Dennis, M. ; Davis, M. ; Ashleigh, R. ; Howell, S. ; Wyatt, M.G. ; Valenti, D. ; Bachoo, P. ; Walker, P. ; MacSweeney, S. ; Davies, J.N. ; Rittoo, D. ; Parvin, S.D. ; Yusuf, W. ; Nice, C. ; Chetter, I. ; Howard, A. ; Chong, P. ; Bhat, R. ; McLain, D. ; Gordon, A. ; Lane, I. ; Hobbs, S. ; Pillay, W. ; Rowlands, T. ; El-Tahir, A. ; Asquith, J. ; Cavanagh, S. ; Dubois, L. ; Forbes, T.L. ; Ashworth, E. ; Baker, S. ; Barakat, H. ; Brady, C. ; Brown, J. ; Bufton, C. ; Chance, T. ; Chrisopoulou, A. ; Cockell, M. ; Croucher, A. ; Dabee, L. ; Dewhirst, N. ; Evans, J. ; Gibson, A. ; Gorst, S. ; Gough, M. ; Graves, L. ; Griffin, M. ; Hatfield, J. ; Hogg, F. ; Howard, S. ; Hughes, C. ; Metcalfe, D. ; Lapworth, M. ; Massey, I. ; Novick, T. ; Owen, G. ; Parr, N. ; Pintar, D. ; Spencer, S. ; Thomson, C. ; Thunder, O. ; Wallace, T. ; Ward, S. ; Wealleans, V. ; Wilson, L. ; Woods, J. ; Zheng, T. ;
Eur Heart J, 2015; 36(31):2061-2069
Evaluation of the Effect of a Continuous Treatment: A Machine Learning Approach with an Application to Treatment for Traumatic Brain Injury.
Kreif, N.; Grieve, R.; Díaz, I.; Harrison, D.;
Health Econ, 2015; 24(9):1213-28
Examination of the Synthetic Control Method for Evaluating Health Policies with Multiple Treated Units.
Kreif, N.; Grieve, R.; Hangartner, D.; Turner, A.J.; Nikolova, S.; Sutton, M.;
Health Econ, 2015;
From sample average treatment effect to population average treatment effect on the treated: combining experimental with observational studies to estimate population treatment effects
Hartman, E.; Grieve, R.; Ramsahai, R.; Sekhon, J.S.
Journal of the Royal Statistical Society: Series A (Statistics in Society), 2015; :n/a-n/a
A MATCHING METHOD FOR IMPROVING COVARIATE BALANCE IN COST-EFFECTIVENESS ANALYSES.
Sekhon, J.S.; Grieve, R.D.;
Health Econ, 2012; 21(6):695-714
Referral to an Extracorporeal Membrane Oxygenation Center and Mortality Among Patients With Severe 2009 Influenza A(H1N1).
Noah, M.A.; Peek, G.J.; Finney, S.J.; Griffiths, M.J.; Harrison, D.A.; Grieve, R.; Sadique, M.Z.; Sekhon, J.S.; McAuley, D.F.; Firmin, R.K.; Harvey, C.; Cordingley, J.J.; Price, S.; Vuylsteke, A.; Jenkins, D.P.; Noble, D.W.; Bloomfield, R.; Walsh, T.S.; Perkins, G.D.; Menon, D.; Taylor, B.L.; Rowan, K.M.;
JAMA, 2011; 306(15):1659-68
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