Professor Richard Grieve


of Health Economics Methodology

I lead a research team whose current research focuses on developing quantitative methods for health economic evaluation. Our expertise is in the design and analysis of health economic evalautions that use observational data as well as RCTs. We are developing methods that address common methodological issues such as confounding due to treatment selection; non-compliance, missing data,  and external validity.

We also undertake applied health economic evaluations predominately in the areas of adult and paediatric intensive care, emergency medicine, elective surgery, and to the evaluation of new health policies. We have recently started an evaluation of the integrated care pioneers, and have undertaken research evaluating the preferences of blood donors for alternative changes to the blood collection service.


My research programme is funded by a five year senior research fellowship from NIHR.

I am the co-director of the LSHTM centre for statistical methodology


Department of Health Services Research and Policy


Statistical Methodology


I teach on the introductory module, introduction to health economics, and organise the economic evaluation module


My main research interests are in developing analytical methods for cost-effectiveness analyses. My current work aims to develop more appropriate analytical methods for dealing with selection bias, missing data and clustered data.

I was the PI for a 3 year ESRC project on methods for reducing selection bias in health economic evaluation. In particular, the study examined Genetic Matching, an automated matching approach that extends traditional propensity score matching. The study involved close collaboration with colleagues at the University of California at Berkeley.

I was also the PI on a 3.5 year MRC funded project to investigate analytical methods for economic evaluations that use data from cluster randomised trials. This work compared multilevel models to robust variance estimators and bootstrap procedures. The project was in collaboration with colleagues at the University of Cambridge and in the Department of Medical Statistics, LSHTM. Recent extensions to this project involved methods for handling missing data in hierarchical settings

I have ongoing interests in applying the techniques of economic evaluation across a diverse range of clinical areas including adult and paediatric intensive care, hepatitis C, mental health, and for routine surgical procedures. 

I am interested in supervising PhD students in the general area of statistical methods and health economic evaluation.

Research Area
Economic evaluation
Health policy
Health technology assessment
Statistical methods
Disease and Health Conditions
Cardiovascular disease

Selected Publications

Extrapolation of Survival Data in Cost-Effectiveness Analyses.
Hawkins, N. ; Grieve, R. ;
Med Decis Making
Estimating causal effects: considering three alternatives to difference-in-differences estimation.
O'Neill, S.; Kreif, N.; Grieve, R.; Sutton, M.; Sekhon, J.S.;
Health Serv Outcomes Res Methodol
Cancer Drugs Fund requires further reform.
Grieve, R. ; Abrams, K. ; Claxton, K. ; Goldacre, B. ; James, N. ; Nicholl, J. ; Parmar, M. ; Parker, C. ; Sekhon, J.S. ; Smeeth, L. ; Spiegelhalter, D. ; Sculpher, M. ;
Examination of the Synthetic Control Method for Evaluating Health Policies with Multiple Treated Units.
Kreif, N.; Grieve, R.; Hangartner, D.; Turner, A.J.; Nikolova, S.; Sutton, M.;
Health Econ
From sample average treatment effect to population average treatment effect on the treated: combining experimental with observational studies to estimate population treatment effects
Hartman, E.; Grieve, R.; Ramsahai, R.; Sekhon, J.S.
Journal of the Royal Statistical Society: Series A (Statistics in Society)
Referral to an Extracorporeal Membrane Oxygenation Center and Mortality Among Patients With Severe 2009 Influenza A(H1N1).
Noah, M.A.; Peek, G.J.; Finney, S.J.; Griffiths, M.J.; Harrison, D.A.; Grieve, R.; Sadique, M.Z.; Sekhon, J.S.; McAuley, D.F.; Firmin, R.K.; Harvey, C.; Cordingley, J.J.; Price, S.; Vuylsteke, A.; Jenkins, D.P.; Noble, D.W.; Bloomfield, R.; Walsh, T.S.; Perkins, G.D.; Menon, D.; Taylor, B.L.; Rowan, K.M.;
See all Professor Richard Grieve's Publications