Professor Chris Frost BA MA DipStat (Cantab)
About Chris Frost
Professor of Medical Statistics
- Chris Frost's Contacts
- Keppel Street
- WC1E 7HT
- T: +44 (0) 207 9272242
I joined LSHTM in 1992, having previously worked at the Department of Environmental & Preventive Medicine, St. Bartholomew’s Medical College on a range of clinical trials and epidemiological projects.
Prior to working at St. Bartholomew's I studied at Pembroke College Cambridge for a degree in Mathematics and the Diploma in Mathematical Statistics.
I currently teach 13 sessions on the Foundations of Medical Statistics course (Analytical Techniques and Linear Regression).
I am Chair of the MSc in Clinical Trials (Distance Learning) Exam Board at LSHTM.
I am a member of the MSc. in Medical Statistics Exam Board at LSHTM.
I am an external examiner for the MSc. in Global Health Science at Oxford University.
Throughout my time at LSHTM I have had a major involvement with the MSc. in Medical Statistics, being course organiser (twice) and admissions tutor as well as the roles listed above.
My research combines methodological research interests with the conduct of collaborative research studies. Over the past decade a large component of this research has been in neurology, with a particular focus on Dementia, Huntington’s Disease (HD) and Multiple Sclerosis (MS). This work includes involvement with the design, conduct and statistical analysis of randomised controlled clinical trials, including a recently published phase II trial in secondary progressive MS that provided statistically significant evidence that Statins slow both the rate of whole-brain atrophy and the clinical progression of the disease.
I also work extensively on clinical cohort studies, including substantial involvement with TRACK-HD, a major international longitudinal study in HD that has given aetiological insight into the disease and also informed the design of future clinical trials.
From a methodological standpoint I have a particular interest in clinical trial design, addressing questions such as quantifying the advantages of extending follow-up, introducing interim visits and introducing novel design features such as run-in periods into trials in neurology.
A new focus of my research is on the design and analysis of clinical trials in glaucoma, with a current research project exploring combining visual field data with imaging outcomes.
My research is not limited to neurology and glaucoma. Recently I have been involved in the design and analysis of randomised controlled trials endeavouring to reduce childhood mortality in India and Guinea-Bissau, and a randomised controlled trial in India that demonstrated the effectiveness of additional schooling on educational attainment. In the past I have worked on major randomised controlled trials and epidemiological studies in many disease areas, including asthma and breast cancer. I have also carried out methodological work on estimating and adjusting for the effect of measurement error in cohort studies where exposure over a lifetime is related to disease
- Neonatal health
- Randomised controlled trials
- Statistical methods
Disease and Health Conditions
- Eye diseases
- Neurological disease
- Europe & Central Asia (all income levels)
- Gambia, The
- United Kingdom
Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial.
Chataway, J. ; Schuerer, N. ; Alsanousi, A. ; Chan, D. ; Macmanus, D. ; Hunter, K. ; Anderson, V. ; Bangham, C.R. ; Clegg, S. ; Nielsen, C. ; Fox, N.C. ; Wilkie, D. ; Nicholas, J.M. ; Calder, V.L. ; Greenwood, J. ; Frost, C. ; Nicholas, R. ;
Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data
Tabrizi, S.J.; Reilmann, R.; Roos, R.A.C.; Durr, A.; Leavitt, B.; Owen, G.; Jones, R.; Johnson, H.; Craufurd, D.; Hicks, S.L.; Kennard, C.; Landwehrmeyer, B.; Stout, J.C.; Borowsky, B.; Scahill, R.I.; Frost, C.; Langbehn, D.R.; Investigators, T.-H.
Lancet Neurology, 2012; 11(1):42-53
Linear mixed models for replication data to efficiently allow for covariate measurement error
Bartlett, J.W.; De Stavola, B.L.; Frost, C.;
Statistics in Medicine, 2009; 28(25):3158-78
Prevalence of Angina in Women Versus Men. A Systematic Review and Meta-Analysis of International Variations Across 31 Countries.
Hemingway, H.; Langenberg, C.; Damant, J.; Frost, C.; Pyörälä, K.; Barrett-Connor, E.;
Circulation, 2008; 117(12):1526-36
Optimizing the design of clinical trials where the outcome is a rate. Can estimating a baseline rate in a run-in period increase efficiency?
Frost, C.; Kenward, M.G.; Fox, N.C.;
Stat Med, 2008; 27(19):3717-31
The effect of measurement error in risk factors that change over time in cohort studies: do simple methods overcorrect for 'regression dilution'?
Frost, C.; White, I.R.;
Int J Epidemiol, 2005; 34(6):1359-68
The analysis of repeated 'direct' measures of change illustrated with an application in longitudinal imaging.
Frost, C.; Kenward, M.G.; Fox, N.C.;
Stat Med, 2004; 23(21):3275-3286
Control of exposure to mite allergen and allergen-impermeable bed covers for adults with asthma
Woodcock, A. ; Forster, L. ; Matthews, E. ; Martin, J. ; Letley, L. ; Vickers, M. ; Britton, J. ; Strachan, D. ; Howarth, P. ; Altmann, D. ; Frost, C. ; Custovic, A. ; Medical Research Council General Practice Research Framework, . ;
New England Journal of Medicine, 2003; 349(3):225-36
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