Dr Helen Fletcher BSc PhD
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I gained a PhD in Medical Microbiology from the University of Leeds and became interested in tuberculosis (TB) in 1999 during my first postdoctoral position at University College London. In 2002 I moved to the Jenner Institute at the University of Oxford as an immunologist for the first-in-man trial of a new TB vaccine, MVA85A. After 10 years at the Jenner Institute I moved to the London School of Hygiene & Tropical Medicine to establish my group, based in the Immunology and Infection Department, which focuses on immune correlates and the host response to TB vaccination. In 2015 I became Director of the TB Centre: http://tb.lshtm.ac.uk/ at the London School of Hygiene & Tropical Medicine and in 2016 I became co-chair of the T-cell Immunology working group for the Collaboration for TB Vaccine Discovery (CTVD) at the Bill & Melinda Gates Foundation.
I am co-organizer of the Vaccine Immunology MSc module with Eleanor Riley and I am a tutor on the Distance Learning programme
My interests are in vaccine development for TB and identification of immune mechanisms important for protection from TB
- Disease control
- Global Health
- Innate immunity
- T-cell immunology
Disease and Health Conditions
- Infectious disease
- Sub-Saharan Africa (all income levels)
- Gambia, The
- South Africa
- BCG Vaccination
- Cellular Immunology
- Malaria Centre
- Microarray Technology
- Next Generation Sequencing
- TB Centre
Profiling the host immune response to tuberculosis vaccines.
Fletcher, H. ;
Transcriptional changes induced by candidate malaria vaccines and correlation with protection against malaria in a human challenge model.
Dunachie, S. ; Berthoud, T. ; Hill, A.V. ; Fletcher, H.A. ;
Distinct Transcriptional and Anti-Mycobacterial Profiles of Peripheral Blood Monocytes Dependent on the Ratio of Monocytes: Lymphocytes.
Naranbhai, V. ; Fletcher, H.A. ; Tanner, R. ; O'Shea, M.K. ; McShane, H. ; Fairfax, B.P. ; Knight, J.C. ; Hill, A.V. ;
EBioMedicine, 2015; 2(11):1619-1626
Gene expression and cytokine profile correlate with mycobacterial growth in a human BCG challenge model.
Matsumiya, M. ; Satti, I. ; Chomka, A. ; Harris, S.A. ; Stockdale, L. ; Meyer, J. ; Fletcher, H.A. ; McShane, H. ;
J Infect Dis, 2014;
Peripheral blood monocyte-to-lymphocyte ratio at study enrollment predicts efficacy of the RTS,S malaria vaccine: analysis of pooled phase II clinical trial data.
Warimwe, G.M. ; Fletcher, H.A. ; Olotu, A. ; Agnandji, S.T. ; Hill, A.V. ; Marsh, K. ; Bejon, P. ;
BMC Med, 2013; 11(1):184
Inhibition of mycobacterial growth in vitro following primary but not secondary vaccination with Mycobacterium bovis BCG.
Fletcher, H.A.; Tanner, R.; Wallis, R.S.; Meyer, J.; Manjaly, Z.R.; Harris, S.; Satti, I.; Silver, R.F.; Hoft, D.; Kampmann, B.; Walker, K.B.; Dockrell, H.M.; Fruth, U.; Barker, L.; Brennan, M.J.; McShane, H.;
Clin Vaccine Immunol, 2013; 20(11):1683-9
Blood monocyte-lymphocyte ratios identify adults at risk of incident tuberculosis amongst patients initiating antiretroviral therapy.
Naranbhai, V.; Hill, A.V.; Abdool Karim, S.S.; Naidoo, K.; Abdool Karim, Q.; Warimwe, G.M.; McShane, H.; Fletcher, H.;
J Infect Dis, 2013;
Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans.
McShane, H. ; Pathan, A.A. ; Sander, C.R. ; Keating, S.M. ; Gilbert, S.C. ; Huygen, K. ; Fletcher, H.A. ; Hill, A.V. ;
Nat Med, 2004; 10(11):1240-4
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