Dr Stefan Flasche


Associate Professor


Faculty of Epidemiology and Population Health
Department of Infectious Disease Epidemiology


Mathematical Modelling of Infectious Diseases
Vaccine Centre


I teach on both the modelling short course and the MSc module, on STEPH and ECCD and I co-organise the short course on epidemiological evaluation of vaccines.


My main research area is the evaluation and optimisation of vaccine interventions for S. pneumoniae through mathematical models. I have also worked on real-time evaluation of pandemic flu and ebola and assessing the impact of vaccines against seasonal influenza, HiB, varicella zoster, melioidosis, malaria and dengue.

Research Area
Child health
Economic evaluation
Infectious disease policy
Public health
Bayesian Analysis
Disease control
Global Health
Mathematical modelling
Disease and Health Conditions
Infectious disease
Pandemic diseases
Emerging Infectious Disease
Respiratory disease

Selected Publications

Public health impact and cost-effectiveness of the RTS,S/AS01 malaria vaccine: a systematic comparison of predictions from four mathematical models.
Penny, M.A.; Verity, R.; Bever, C.A.; Sauboin, C.; Galactionova, K.; Flasche, S.; White, M.T.; Wenger, E.A.; Van de Velde, N.; Pemberton-Ross, P.; Griffin, J.T.; Smith, T.A.; Eckhoff, P.A.; Muhib, F.; Jit, M.; Ghani, A.C.;
The Long-Term Safety, Public Health Impact, and Cost-Effectiveness of Routine Vaccination with a Recombinant, Live-Attenuated Dengue Vaccine (Dengvaxia): A Model Comparison Study.
Flasche, S. ; Jit, M. ; Rodríguez-Barraquer, I. ; Coudeville, L. ; Recker, M. ; Koelle, K. ; Milne, G. ; Hladish, T.J. ; Perkins, T.A. ; Cummings, D.A. ; Dorigatti, I. ; Laydon, D.J. ; España, G. ; Kelso, J. ; Longini, I. ; Lourenco, J. ; Pearson, C.A. ; Reiner, R.C. ; Mier-Y-Terán-Romero, L. ; Vannice, K. ; Ferguson, N. ;
PLoS Med
The Potential for Reducing the Number of Pneumococcal Conjugate Vaccine Doses While Sustaining Herd Immunity in High-Income Countries.
Flasche, S. ; Van Hoek, A.J. ; Goldblatt, D. ; Edmunds, W.J. ; O'Brien, K.L. ; Scott, J.A. ; Miller, E. ;
PLoS Med
Measuring the impact of Ebola control measures in Sierra Leone.
Kucharski, A.J.; Camacho, A.; Flasche, S.; Glover, R.E.; Edmunds, W.J.; Funk, S.;
Proc Natl Acad Sci U S A
The impact of specific and non-specific immunity on the ecology of Streptococcus pneumoniae and the implications for vaccination.
Flasche, S. ; Edmunds, W.J. ; Miller, E. ; Goldblatt, D. ; Robertson, C. ; Choi, Y.H. ;
Proc Biol Sci
Assessing Optimal Target Populations for Influenza Vaccination Programmes: An Evidence Synthesis and Modelling Study.
Baguelin, M. ; Flasche, S. ; Camacho, A. ; Demiris, N. ; Miller, E. ; Edmunds, W.J. ;
PLoS Med
Effect of pneumococcal conjugate vaccination on serotype-specific carriage and invasive disease in England: a cross-sectional study.
Flasche, S. ; Van Hoek, A.J. ; Sheasby, E. ; Waight, P. ; Andrews, N. ; Sheppard, C. ; George, R. ; Miller, E. ;
PLoS Med
See all Dr Stefan Flasche's Publications