Professor Paul Fine AB VMD MSc PhD
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- WC1E 7HT
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Paul Fine trained originally in zoology, veterinary medicine, parasitology and epidemiology, and joined the staff of LSHTM in 1976. His major methodological interests have been in infection dynamics, family studies, genetics, and the evaluation of vaccines (efficacy, adverse reactions and impact), applied to a variety of infections. Much of his earlier work concentrated upon vertical (from parent to progeny) transmission of infections and upon measles and pertussis in the UK. He directed a large epidemiological research programme (the "Karonga Prevention Study") in Malawi from 1978-2006, concentrating at first upon leprosy, then tuberculosis, and ultimately HIV, and including demographic surveillance, vaccine evaluation, and studies of other infections in a rural population in northern Malawi. Since 1997 he has worked on a wide variety of vaccine issues, including the evaluation of non-specific effects of vaccines, methods for field evaluation of veterinary vaccines, the implications of the transmissibility of oral polio vaccine viruses for the polio eradication initiative, and methods for optimising vaccination schedules.
He is involved in epidemiology-related teaching on several of the MSc and short courses offered by the LSHTM, and is responsible for the Epidemiology and Control of Communicable Diseases study unit which is run in February and March each year.
He has broad interests in infectious disease epidemiology, with particular emphasis upon vaccines (trials, safety and efficacy evaluations of BCG, measles, pertussis, mumps, polio), mycobacterial diseases (including genetics, immune responses, risk factors, vaccine and drug trials of leprosy and tuberculosis) and family studies (in the broadest sense, including both Mendelian and non-Mendelian inheritance). He directed a large study of tuberculosis, leprosy and HIV in northern Malawi (the Karonga Prevention Study - see http://www.lshtm.ac.uk/ideu/kps ) from 1978 to 2006.
- Clinical trials
Disease and Health Conditions
- Infectious disease
Epidemiology--a science for the people.
Fine, P. ; Goldacre, B. ; Haines, A. ;
Lancet, 2013; 381(9874):1249-52
Patterns and trends of leprosy in Mexico: 1989-2009.
Larrea, M.R. ; Carreño, M.C. ; Fine, P.E. ;
Lepr Rev, 2012; 83(2):184-94
What has Karonga taught us? Tuberculosis studied over three decades.
Crampin, A.C.; Glynn, J.R.; Fine, P.E.;
Int J Tuberc Lung Dis, 2009; 13(2):153-64
Epidemiological studies of the 'non-specific effects' of vaccines: I - data collection in observational studies.
Fine, P.E.; Williams, T.N.; Aaby, P.; Källander, K.; Moulton, L.H.; Flanagan, K.L.; Smith, P.G.; Benn, C.S.; on behalf of the Working Group on Non-specific Effects of Vaccines*, .;
Trop Med Int Health, 2009; 14(9):969-76
Estimating the extent of vaccine-derived poliovirus infection.
Wringe, A.; Fine, P.E.; Sutter, R.W.; Kew, O.M.;
PLoS One, 2008; 3(10):e3433
Effect of BCG vaccination on childhood tuberculous meningitis and miliary tuberculosis worldwide: a meta-analysis and assessment of cost-effectiveness.
Trunz, B.B.; Fine, P.; Dye, C.;
Lancet, 2006; 367(9517):1173-80
The Interval between Successive Cases of an Infectious Disease
Fine, P. E.
American Journal of Epidemiology, 2003; 158(11):1039-47
Stopping a polio outbreak in the post-eradication era
Fine, P.E.; Sutter, R.W.; Orenstein, W.A.;
Dev Biol (Basel), 2001; 105:129-47; discussion 149-50
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