Abdi Elmi BSc MSc
- 380/Laboratory 202
- LSHTM
- Keppel Street
- London
- WC1E 7HT
- T: 0207 958 8391
- I have BSc in Microbiology from Surrey University and MSc Molecular Microbiology from Nottingham University
- I have substantial element of molecular microbiology research experience
- I joined the Pathogen Molecular Biology Department in 2003 to work as a Scientific Laboratory Officer
Affiliation
Teaching
Genomic Resources Facility
I provide training in the latest research techniques for PhD students, postdocs and senior staff
- Microarray Technology training
- Nucleic acid extraction for Microarray and latest sequenceing techniques
- Quantification and quality control of DNA and RNA using agilent platform
In addition to training I supervise MSc students contributing significantly to the design and implementation of their projects
Departmental shared facility that I am responsible
- Agilent 2100 platform
- Gel imaging systems and X-Ray developer
Laboratory management
- I am responsible for the administrative and laboratory management duties of our dynamic research group (15-20) ensuring an observance of health and safety
- I am the School's deputy Radiation Safety Officer
Research
My research interest lies in the area of bacteria host-pathogen interactions, particularly interactions that mediate the balance of host defenses and pathogen virulence mechanisms. My current project involves understanding the role of Outer Membrane Vesicles (OMVs) in Campylobacter jejuni infection using multidisciplinary techniques, combining, SDS-PAGE, MS, Immunoblot, Immunogold labelling, ELISA, Cell adhesion, invasion assays and Immunoflourescence.
I also have an active interest in exploring the functional roles of individual glycoprotein mutants of C. jejuni during its contact with human adenocarcinoma cells (Caco-2 and T84), which possess many of the properties of the small intestine of humans.
I am also actively involved in multiple projects with both national and international collaborators, all aimed to unveil the pathogenisis mechanism of C. jejuni. C. jejuni itself being the leading cause of foodborne bacterial gastroenteritis worldwide as well as a causative agent of Guillain-Barré syndrome.
Research areas
- Bacteria
Disciplines
- Genetics
- Genomics
- Immunology
- Molecular biology
- Molecular epidemiology
Other interests
- Microarrays
- Microbial Pathogenicity
-
Selected publications
-
Increase in Campylobacter jejuni invasion of intestinal epithelial cells under low oxygen co-culture conditions that reflect the in vivo environment.
Mills, D.C.; Gundogdu, O.; Elmi, A.; Bajaj-Elliott, M.; Taylor, P.W.; Wren, B.W.; Dorrell, N.;
Infect Immun, 2012; 80(5):1690-8
-
The Campylobacter jejuni transcriptional regulator Cj1556 plays a role in the oxidative and aerobic (O2) stress response and is important for bacterial survival in vivo.
Gundogdu, O.; Mills, D.C.; Elmi, A.; Martin, M.J.; Wren, B.W.; Dorrell, N.;
J Bacteriol, 2011; 193(16):4238-49
-
Campylobacter jejuni alters surface capsular polysaccharide when co-cultured with epithelial cells.
Corcionivoschi, N.; Clyne, M.; Lyons, A.; Elmi, A.; Gundogdu, O.; Wren, B.W.; Dorrell, N.; Karlyshev, A.V.; Bourke, B.;
Infect Immun, 2009; 77(5):1959-67
-
A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in eliciting host bactericidal immune responses to Campylobacter jejuni.
Zilbauer M; Dorrell N; Elmi A; Lindley KJ; Schüller S; Jones HE; Klein NJ; Núnez G; Wren BW; Bajaj-Elliott M
Cell Microbiol, 2007; 9(10):2404-2416
-
Genetics and properties of a novel capsule produced by untypable strain X of C-jejuni
Karlyshev, A.; Quail, M.A.; Stevens, K.; Elmi, A.; Parkhill, J.; Wren, B.W.
Zoonoses and Public Health, 2007; 54:6-6
-
Investigation of the role of two Campylobacter jejuni glycoproteins during bacterial interactions with human intestinal epithelial cells
Elmi, A.D.; Zilbauer, M.; Bajaj-Elliott, M.; Wren, B.; Dorrell, N.
Zoonoses and Public Health, 2007; 54:99-99
-
A major role for intestinal epithelial nucleotide oligomerization domain (NOD) protein NOD1 in mediating host bactericidal activity against Campylobacter jejuni
Zilbauer, M.; Dorrell, N.; Elmi, A.; Nunez, G.; Klein, N.J.; Wren, B.W.; Bajaj-Elliott, M.
Zoonoses and Public Health, 2007; 54:148-148
-
Comparative phylogenomics of the food-borne pathogen Campylobacter jejuni reveals genetic markers predictive of infection source.
Champion, O.L.; Gaunt, M.W.; Gundogdu, O.; Elmi, A.; Witney, A.A.; Hinds, J.; Dorrell, N.; Wren, B.W.;
Proc Natl Acad Sci U S A, 2005; 102(44):16043-8
- → View all Abdi Elmi's publications
