Chris Drakeley MI Biol PhD

Reader in Infection & Immunity, Director of LSHTM Malaria Centre

• Affiliation
• Teaching
• Research
• Publications

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• 238b
• LSHTM
• Keppel Street
• London
• WC1E 7HT
• T: +44 (0)20 7927 2289
• F: +44 (0)20 7637 4314

Chris Drakeley has diplomas in Parasitology and Physiology and is a graduate of the Institute of Biology in Immunology. After working on the anti-malarial drug programme at Burroughs Wellcome, in 1990 he went to the MRC research laboratories in The Gambia as a member of LSHTM research staff. Chris was based at the Ifakara Centre in southern Tanzania as a Post-doctoral biologist before rejoining LSHTM in 1999 and returning to The Gambia. In 2001 Chris went to Moshi in North Eastern Tanzania as part of LSHTM's commitment to the Joint Malaria Programme. He is now a senior lecturer in immuno-epidemiology based in London and Director of the LSHTM Malaria Centre.

Affiliation

• Immunology and Infection Department

Teaching

Honorary Lecturer Kilimanjaro Christian Medical Centre, Tanzania

DL tutor - Immunology unit - Infectious diseases

Tutor Malaria Epidemiology Module

Research

My research focus is on the transmission biology and epidemiology of malaria. The broad aim is to identify and target the infectious reservoir of the malaria parasite in the human host. Specific studies involve 1)who in endemic populations carries these sexual age parasites, gametocytes, and is responsible for infecting mosquitoes 2)and what are the factors that influence the dynamics of carriage including drugs and specific and non-specific anti-malarial immunity 3) mathematical modelling of the effects of interventions on the transmission of malaria. Most recently, we have been increasingly interested in identifying methodologies to more accurately define malaria transmission that can be subsequently used for monitoring and evaluation of malaria control interventions.

I have spent 16 years working in sub-saharan Africa. Most recently this was as part of the Joint Malaria Programme collaboration (with the National Institute for Medical Research of Tanzania, the Kilimanjaro Christian Medical College and University of Copenhagen) in north-east Tanzania in area where malaria transmission ranges from zero to extremely high. I am currently involved in a number of field studies in Tanzania (human genetics and malaria, a malaria vaccine trial and drug trials to reduce parasite infectivity) as well as teaching of MSc and supervision of Tanzanian students.

• Selected publications

• Epidemiology and Infectivity of Plasmodium falciparum and Plasmodium vivax Gametocytes in Relation to Malaria Control and Elimination.

  Bousema, T. ; Drakeley, C. ;

  Clin Microbiol Rev, 2011; 24(2):377-410

• Serological markers suggest heterogeneity of effectiveness of malaria control interventions on bioko island, equatorial Guinea.

  Cook, J.; Kleinschmidt, I.; Schwabe, C.; Nseng, G.; Bousema, T.; Corran, P.H.; Riley, E.M.; Drakeley, C.J.;

  PLoS One, 2011; 6(9):e25137

• Serologic markers for detecting malaria in areas of low endemicity, somalia, 2008.

  Bousema, T.; Youssef, R.M.; Cook, J.; Cox, J.; Alegana, V.A.; Amran, J.; Noor, A.M.; Snow, R.W.; Drakeley, C.;

  Emerg Infect Dis, 2010; 16(3):392-9

• Identification of Hot Spots of Malaria Transmission for Targeted Malaria Control.

  Bousema, T.; Drakeley, C.; Gesase, S.; Hashim, R.; Magesa, S.; Mosha, F.; Otieno, S.; Carneiro, I.; Cox, J.; Msuya, E.; Kleinschmidt, I.; Maxwell, C.; Greenwood, B.; Riley, E.; Sauerwein, R.; Chandramohan, D.; Gosling, R.;

  J Infect Dis, 2010; 201(11):1764-74

• Rapid assessment of malaria transmission using age-specific sero-conversion rates.

  Stewart, L.; Gosling, R.; Griffin, J.; Gesase, S.; Campo, J.; Hashim, R.; Masika, P.; Mosha, J.; Bousema, T.; Shekalaghe, S.; Cook, J.; Corran, P.; Ghani, A.; Riley, E.M.; Drakeley, C.;

  PLoS One, 2009; 4(6):e6083

• Submicroscopic Infection in Plasmodium falciparum-Endemic Populations: A Systematic Review and Meta-Analysis.

  Okell, L.C.; Ghani, A.C.; Lyons, E.; Drakeley, C.J.;

  J Infect Dis, 2009; 200(10):1509-17

• Primaquine clears submicroscopic Plasmodium falciparum gametocytes that persist after treatment with sulphadoxine-pyrimethamine and artesunate

  Shekalaghe, S.; Drakeley, C.; Gosling, R.; Ndaro, A.; van Meegeren, M.; Enevold, A.; Alifrangis, M.; Mosha, F.; Sauerwein, R.; Bousema, JT.

  Plos Clinical Trials, 2007; 2(10)

• The epidemiology of Plasmodium falciparum gametocytes: weapons of mass dispersion.

  Drakeley, C.; Sutherland, C.; Bousema, J.T.; Sauerwein, R.W.; Targett, G.A.;

  Trends Parasitol, 2006; 22(9):424-30

• → View all Chris Drakeley's publications

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