Dr Nick Dorrell BPharmHons MRPharmS PhD FHEA
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Nick Dorrell originally trained as a pharmacist, obtaining a Bachelor of Pharmacy degree from the University of Bath in 1988 and completing his pre-registration training at King's College Hospital in 1989. After two years working in hospital pharmacy, he returned to Bath to study DNA repair in Escherichia coli, completing his PhD in 1993. He joined Brendan Wren's research group at St Bartholomew's Hospital in January 1994, working on many different aspects of bacterial pathogenicity of Brucella species, Yersinia species and Helicobacter pylori. He joined the LSHTM in July 1999 and is continuing to study the pathogenicity of both H. pylori and predominantly Campylobacter jejuni.
In September 2016, Nick has taken on the role of Taught Programme Director for the Faculty of Infectious & Tropical Diseases, with oversight of teaching on all the MSc programmes, Short Courses and modules run by the Faculty. Previously Nick was the Course Director for the MSc course in Medical Microbiology (http://www.lshtm.ac.uk/prospectus/masters/msmm.html) from 2005 to 2016. During this time, he also acted as Module Organiser for the MSc Modules on Core Bacteriology, Clinical Bacteriology and Clinical Virology and also lectured on the MSc Module Advanced Training in Molecular Biology. He chaired the Course Committee and was a member of the Exam Board for the MSc in Medical Microbiology.
Nick currently supervises three PhD students and also supervises MSc research projects at the LSHTM.
Nick successfully completed the Professional Certificate in Teaching and Learning in Higher and Professional Education (with Distinction) at the Institute of Education (University of London) in 2006 and became a Fellow of The Higher Education Academy in 2007.
Current research interests cover five main areas of bacterial pathogenesis:-
- Role of outer membrane vesicles during C. jejuni infection;
- C. jejuni oxidative and aerobic stress responses;
- Mechanisms of C. jejuni invasion of intestinal epithelial cells;
- Role of the C. jejuni Type VI Secretion System;
- The innate immune response to C. jejuni infection.
A long term interest has been developing new technology associated with functional genomic research. Nick was involved in the construction of the first DNA microarray produced by the Bacterial Microarray Group at St George's (http://bugs.sghms.ac.uk/index.php) and acted as User Group Co-ordinator for both the C. jejuni and H. pylori microarrays produced by the BμG@S group.
Nick has had a long involvement with the Society of General Microbiology (http://www.sgm.ac.uk). Nick stood down as Chair of the Prokaryotic Division in September 2013 after the 2 year term of office. Previously Nick was Chair Elect of the Prokaryotic Division (2009-2011), a member of the Prokaryotic Division (2008-2009) and Convener of the Microbial Infection Group (2005-2008), having served as a committee member of the Microbial Infection Group since 2001. He was also a member (2001-2007) of the Steering Committee of ARK Genomics (http://www.ark-genomics.org) based at the Roslin Institute (Edinburgh).
- Disease control
- Innate immunity
- Cell biology
- Molecular biology
Disease and Health Conditions
- Diarrhoeal diseases
- Infectious disease
- Zoonotic disease
- Euro area
- United Kingdom
- Bacterial Biofilms
- Bacterial Infections
- Campylobacter Jejuni
- Helicobacter pylori
- Infectious Diseases
- Microarray Technology
Campylobacter jejuni outer membrane vesicle-associated proteolytic activity promotes bacterial invasion by mediating cleavage of intestinal epithelial cell E-cadherin and occludin.
Elmi, A. ; Nasher, F. ; Jagatia, H. ; Gundogdu, O. ; Bajaj-Elliott, M. ; Wren, B. ; Dorrell, N. ;
Cell Microbiol, 2016; 18(4):561-72
The Campylobacter jejuni MarR-like transcriptional regulators RrpA and RrpB both influence bacterial responses to oxidative and aerobic stresses.
Gundogdu, O. ; da Silva, D.T. ; Mohammad, B. ; Elmi, A. ; Mills, D.C. ; Wren, B.W. ; Dorrell, N. ;
Front Microbiol, 2015; 6:724
Campylobacter jejuni lipooligosaccharide sialylation, phosphorylation and amide/ester linkage modifications fine-tune human Toll-like receptor 4 activation.
Stephenson, H.N.; John, C.M.; Naz, N.; Gundogdu, O.; Dorrell, N.; Wren, B.W.; Jarvis, G.A.; Bajaj-Elliott, M.;
J Biol Chem, 2013; 288(27):19661-72
Increase in Campylobacter jejuni invasion of intestinal epithelial cells under low oxygen co-culture conditions that reflect the in vivo environment.
Mills, D.C.; Gundogdu, O.; Elmi, A.; Bajaj-Elliott, M.; Taylor, P.W.; Wren, B.W.; Dorrell, N.;
Infect Immun, 2012; 80(5):1690-8
Campylobacter jejuni outer membrane vesicles play an important role in bacterial interactions with human intestinal epithelial cells.
Elmi, A.; Watson, E.; Sandu, P.; Gundogdu, O.; Mills, D.C.; Inglis, N.F.; Manson, E.; Imrie, L.; Bajaj-Elliott, M.; Wren, B.W.; Smith, D.G.; Dorrell, N.;
Infect Immun, 2012; 80(12):4089-98
Genomic variations define divergence of water/wildlife-associated Campylobacter jejuni niche specialists from common clonal complexes.
Hepworth, P.J.; Ashelford, K.E.; Hinds, J.; Gould, K.A.; Witney, A.A.; Williams, N.J.; Leatherbarrow, H.; French, N.P.; Birtles, R.J.; Mendonca, C.; Dorrell, N.; Wren, B.W.; Wigley, P.; Hall, N.; Winstanley, C.;
Environ Microbiol, 2011; 13(6):1549-60
The Campylobacter jejuni transcriptional regulator Cj1556 plays a role in the oxidative and aerobic (O2) stress response and is important for bacterial survival in vivo.
Gundogdu, O.; Mills, D.C.; Elmi, A.; Martin, M.J.; Wren, B.W.; Dorrell, N.;
J Bacteriol, 2011; 193(16):4238-49
Re-annotation and re-analysis of the Campylobacter jejuni NCTC11168 genome sequence.
Gundogdu, O.; Bentley, S.D.; Holden, M.T.; Parkhill, J.; Dorrell, N.; Wren, B.W.;
BMC Genomics, 2007; 8:162
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