Dr Nick Dorrell BPharmHons MRPharmS PhD FHEA

Senior Lecturer in Bacterial Pathogenesis

• Affiliation
• Teaching
• Research
• Publications

• 
• Room 382
• LSHTM
• Keppel Street
• London
• WC1E 7HT
• T: 020 7927 2838
• F: 020 7927 2131

Nick Dorrell originally trained as a pharmacist, obtaining a Bachelor of Pharmacy degree from the University of Bath in 1988 and completing his pre-registration training at King's College Hospital in 1989. After two years working in hospital pharmacy, he returned to Bath to study DNA repair in Escherichia coli, completing his PhD in 1993. He joined Brendan Wren's research group at St Bartholomew's Hospital in January 1994, and worked on many different aspects of bacterial pathogenicity in Brucella species, Yersinia species and Helicobacter pylori. He joined the LSHTM in July 1999 and is continuing to study the pathogenicity of both H. pylori and Campylobacter jejuni.

Affiliation

• Department of Pathogen Molecular Biology

Teaching

Nick has been the Course Director for the MSc course in Medical Microbiology (http://www.lshtm.ac.uk/prospectus/masters/msmm.html) since 2005. He organises the MSc Modules on Core Bacteriology, Clinical Bacteriology and Clinical Virology and also teaches on the MSc Module Advanced Practical Training in Molecular Biology. He chairs the Course Committee and is a member of the Exam Board for the MSc in Medical Microbiology.

He supervises both PhD (currently three students) and MSc research projects at the LSHTM.

Nick successfully completed the Professional Certificate in Teaching and Learning in Higher and Professional Education (with Distinction) at the Institute of Education (University of London) in 2006 and became a Fellow of The Higher Education Academy in 2007.

Research

Current research interests cover six main areas of bacterial pathogenesis:-

• Role of outer membrane vesicles during C. jejuni infection
• Regulation of C. jejuni gene expression during pathogenesis
• Mechanisms of C. jejuni invasion of intestinal epithelial cells
• Formation and role in pathogenesis of H. pylori biofilms
• Development of models of human intestinal epithelium to study C. jejuni infection
• The innate immune response to C. jejuni infection

A major long term interest is in developing the new technology associated with functional genomic research, particularly DNA microarrays. He was involved in the construction of the first DNA microarray produced by the Bacterial Microarray Group at St George's (http://bugs.sghms.ac.uk/index.php). He is currently User Group Co-ordinator for both the C. jejuni and H. pylori microarrays produced by the BμG@S group.

Nick is currently Chair of the Prokaryotic Division of the Society of General Microbiology (http://www.sgm.ac.uk). Previously Nick was Chair Elect of the Prokaryotic Division (2009-2011), a member of the Prokaryotic Division (2008-2009) and Convener of the Microbial Infection Group (2005-2008), having served as a committee member since 2001. He is also a member (since 2001) of the Steering Committee of ARK Genomics (http://www.ark-genomics.org) based at the Roslin Institute (Edinburgh).

• Selected publications

• Increase in Campylobacter jejuni invasion of intestinal epithelial cells under low oxygen co-culture conditions that reflect the in vivo environment.

  Mills, D.C.; Gundogdu, O.; Elmi, A.; Bajaj-Elliott, M.; Taylor, P.W.; Wren, B.W.; Dorrell, N.;

  Infect Immun, 2012; 80(5):1690-8

• Genomic variations define divergence of water/wildlife-associated Campylobacter jejuni niche specialists from common clonal complexes.

  Hepworth, P.J. ; Ashelford, K.E. ; Hinds, J. ; Gould, K.A. ; Witney, A.A. ; Williams, N.J. ; Leatherbarrow, H. ; French, N.P. ; Birtles, R.J. ; Mendonca, C. ; Dorrell, N. ; Wren, B.W. ; Wigley, P. ; Hall, N. ; Winstanley, C. ;

  Environ Microbiol, 2011;

• The Campylobacter jejuni transcriptional regulator Cj1556 plays a role in the oxidative and aerobic (O2) stress response and is important for bacterial survival in vivo.

  Gundogdu, O.; Mills, D.C.; Elmi, A.; Martin, M.J.; Wren, B.W.; Dorrell, N.;

  J Bacteriol, 2011; 193(16):4238-49

• Delineation of the Innate and Adaptive T-Cell Immune Outcome in the Human Host in Response to Campylobacter jejuni Infection.

  Edwards, L.A.; Nistala, K.; Mills, D.C.; Stephenson, H.N.; Zilbauer, M.; Wren, B.W.; Dorrell, N.; Lindley, K.J.; Wedderburn, L.R.; Bajaj-Elliott, M.;

  PLoS One, 2010; 5(11):e15398

• In vitro effects of human beta-defensins on planktonic cells, bacterial adhesion and biofilm formation of the two sequenced strains of H-pylori

  Kazakos, E.I.; Alhaj-Hussein, B.; Bajaj-Elliott, M.; Dorrell, N.

  Helicobacter, 2010; 15(4):320-320

• A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in eliciting host bactericidal immune responses to Campylobacter jejuni.

  Zilbauer M; Dorrell N; Elmi A; Lindley KJ; Schüller S; Jones HE; Klein NJ; Núnez G; Wren BW; Bajaj-Elliott M

  Cell Microbiol, 2007; 9(10):2404-2416

• Re-annotation and re-analysis of the Campylobacter jejuni NCTC11168 genome sequence.

  Gundogdu, O.; Bentley, S.D.; Holden, M.T.; Parkhill, J.; Dorrell, N.; Wren, B.W.;

  BMC Genomics, 2007; 8:162

• Comparative phylogenomics of the food-borne pathogen Campylobacter jejuni reveals genetic markers predictive of infection source.

  Champion, O.L.; Gaunt, M.W.; Gundogdu, O.; Elmi, A.; Witney, A.A.; Hinds, J.; Dorrell, N.; Wren, B.W.;

  Proc Natl Acad Sci U S A, 2005; 102(44):16043-8

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