Hazel Dockrell BA PhD

Professor of Immunology

• Affiliation
• Teaching
• Research
• Publications

• 
• LSHTM
• Keppel Street
• London
• WC1E 7HT
• T: +44 (0)20 7927 2466
• F: +44 (0)20 7636 7679

Following a BA (Mod) in Microbiology at Trinity College, Dublin I did my PhD working on autoimmunity at the Royal Dental Hospital of London.  I then worked as a postdoctoral fellow at the Middlesex Hospital Medical School, London on the immunology of malaria.  I joined the School in 1985 working first on the immunology of leprosy and then on tuberculosis.

Affiliation

• Immunology and Infection Department
• Director’s Office

Teaching

I contribute to teaching on the MSc Immunology of Infectious Diseases course and the Diploma in Tropical Medicine & Hygiene, and helped write parts of the Distance Learning MSc Infectious Diseases course on the immunology of infection.

Research

As Special Advisor to the Director on Overseas Programmes, I am helping co-ordinate the LSHTM's research programmes overseas so that we can make better links between the institutions with whom we collaborate and between our many individual research projects. We are currently carrying out an audit of all the work LSHTM does overseas so that we can make strategic decisions about where to focus our capacity building efforts.

My current research focuses on the development of correlates of protection against mycobacterial disease. In large scale immuno-epidemiology projects in the UK and Malawi we have studied the immune response induced by BCG vaccination of young adults in situations where it does, or does not, provide protection against pulmonary tuberculosis. This work led to further comparisons of immunity induced by infant BCG vaccination in both sites, in South Korea and in The Gambia. T cell recognition of new M. tuberculosis antigens, and T cell phenotypes are being assessed in BCG vaccinated infants and in TB patients. We are also using microarray technology to identify novel genes that could be used to monitor T cell responses to M. tuberculosis and to predict patients who may develop recurrent disease. We are also part of the IDEAL leprosy Consortium which aims to develop diagnostic reagents using M.leprae specific peptides to monitor leprosy transmission.

My group currently consists of three postdoctoral fellows, a research assistant and three PhD students.

• Selected publications

• BCG Vaccination Induces Different Cytokine Profiles Following Infant BCG Vaccination in the UK and Malawi.

  Lalor, M.K. ; Floyd, S. ; Gorak-Stolinska, P. ; Ben-Smith, A. ; Weir, R.E. ; Smith, S.G. ; Newport, M.J. ; Blitz, R. ; Mvula, H. ; Branson, K. ; McGrath, N. ; Crampin, A.C. ; Fine, P.E. ; Dockrell, H.M. ;

  J Infect Dis, 2011; 204(7):1075-85

• Mycobacterium tuberculosis PPD-induced immune biomarkers measurable in vitro following BCG vaccination of UK adolescents by multiplex bead array and intracellular cytokine staining.

  Smith, S.G.; Lalor, M.K.; Gorak-Stolinska, P.; Blitz, R.; Beveridge, N.E.; Worth, A.; McShane, H.; Dockrell, H.M.;

  BMC Immunol, 2010; 11(1):35

• Population differences in immune responses to Bacille Calmette-Guérin vaccination in infancy.

  Lalor, M.K.; Ben-Smith, A.; Gorak-Stolinska, P.; Weir, R.E.; Floyd, S.; Blitz, R.; Mvula, H.; Newport, M.J.; Branson, K.; McGrath, N.; Crampin, A.C.; Fine, P.E.; Dockrell, H.M.;

  J Infect Dis, 2009; 199(6):795-800

• Complex cytokine profiles induced by BCG vaccination in UK infants.

  Lalor, M.K.; Smith, S.G.; Floyd, S.; Gorak-Stolinska, P.; Weir, R.E.; Blitz, R.; Branson, K.; Fine, P.E.; Dockrell, H.M.;

  Vaccine, 2009; 28(6):1635-41

• Immunological Outcomes of New Tuberculosis Vaccine Trials: WHO Panel Recommendations.

  Hanekom, W.A.; Dockrell, H.M.; Ottenhoff, T.H.; Doherty, T.M.; Fletcher, H.; McShane, H.; Weichold, F.F.; Hoft, D.F.; Parida, S.K.; Fruth, U.J.;

  PLoS Med, 2008; 5(7):e145

• Differential Gene Expression Identifies Novel Markers of CD4(+) and CD8(+) T Cell Activation Following Stimulation by Mycobacterium tuberculosis.

  Cliff, J.M.; Andrade, I.N.; Mistry, R.; Clayton, C.L.; Lennon, M.G.; Lewis, A.P.; Duncan, K.; Lukey, P.T.; Dockrell, H.M.;

  J Immunol , 2004; 173(1):485-93

• Increased interleukin-4 production by CD8 and gamma delta T cells in health-care workers is associated with the subsequent development of active tuberculosis

  Ordway, D. J.; Costa, L.; Martins, M.; Silveira, H.; Amaral, L.; Arroz, M. J.; Ventura, F. A.; Dockrell, H. M.

  Journal of Infectious Diseases, 2004; 190(4):756

• BCG-induced increase in interferon-gamma response to mycobacterial antigens and efficacy of BCG vaccination in Malawi and the UK: two randomised controlled studies

  Black, G. F.; Weir, R. E.; Floyd, S.; Bliss, L.; Warndorff, D. K.; Crampin, A. C.; Ngwira, B.; Sichali, L.; Nazareth, B.; Blackwell, J. M.; Branson, K.; Chaguluka, S. D.; Donovan, L.; Jarman, E.; King, E.; Fine, P. E. M.; Dockrell, H. M.

  Lancet, 2002; 359(9315):1393-1401

• → View all Hazel Dockrell's publications

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