Professor Hazel Dockrell BA PhD
- Hazel Dockrell's Contacts
- Keppel Street
- WC1E 7HT
- T: 0209272466
I initially did a BA degree in Microbiology at Trinity College Dublin, followed by a PhD in autoimmunity at the Royal Dental Hospital of London. After a period as a postdoc at the Middlesex Hospital Medical School working on malaria, I moved to the LSHTM in 1985. Initially I was working on the immunology of leprosy but this then led me into tuberculosis, BCG vaccination and biomarkers. I now also help as Special Advisor on our Overseas Programmes in Africa.
With members of my research group, I teach and tutor on the MSc Immunology of Infectious Diseases course.
Our research aims to understand the basis of protective immunity against tuberculosis and in particular to identify biomarker signatures that would help in the development of new TB vaccines. We are also interested in how TB treatment modulates immune and gene expression signatures, and in how co-morbidity with helminth infections or diabetes impact on immunity to Mycobacterium tuberculosis.
- Capacity strengthening
- Global Health
- T-cell immunology
Disease and Health Conditions
- Chronic Fatigue Syndrome
- Infectious disease
- East Asia & Pacific (all income levels)
- European Union
- Sub-Saharan Africa (all income levels)
- Korea, Rep.
- South Africa
- United Kingdom
- BCG Vaccination
- Biomarkers & Surrogate Markers
- CD8 T Cells
- Cellular Immunology
- Developing countries
- East Africa
- Flow Cytometry
- Gene Expression
- Infectious Diseases
- TB Centre
- sub-saharan africa
Excessive Cytolytic Responses Predict Tuberculosis Relapse After Apparently Successful Treatment.
Cliff, J.M.; Cho, J.E.; Lee, J.S.; Ronacher, K.; King, E.C.; van Helden, P.; Walzl, G.; Dockrell, H.M.;
J Infect Dis, 2016; 213(3):485-95
Mycobacterium tuberculosis-specific CD4(+) T-cell response is increased, and Treg cells decreased, in anthelmintic-treated patients with latent TB.
Toulza, F.; Tsang, L.; Ottenhoff, T.H.; Brown, M.; Dockrell, H.M.;
Eur J Immunol, 2016; 46(3):752-61
Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines.
Smith, S.G. ; Smits, K. ; Joosten, S.A. ; van Meijgaarden, K.E. ; Satti, I. ; Fletcher, H.A. ; Caccamo, N. ; Dieli, F. ; Mascart, F. ; McShane, H. ; Dockrell, H.M. ; Ottenhoff, T.H. ; TBVI TB Biomarker Working Group, . ;
PLoS One, 2015; 10(9):e0138042
TANDEM: understanding diabetes and tuberculosis.
van Crevel, R. ; Dockrell, H.M. ; TANDEM Consortium, . ;
Lancet Diabetes Endocrinol, 2014; 2(4):270-2
Detection of Tuberculosis in HIV-Infected and -Uninfected African Adults Using Whole Blood RNA Expression Signatures: A Case-Control Study.
Kaforou, M. ; Wright, V.J. ; Oni, T. ; French, N. ; Anderson, S.T. ; Bangani, N. ; Banwell, C.M. ; Brent, A.J. ; Crampin, A.C. ; Dockrell, H.M. ; Eley, B. ; Heyderman, R.S. ; Hibberd, M.L. ; Kern, F. ; Langford, P.R. ; Ling, L. ; Mendelson, M. ; Ottenhoff, T.H. ; Zgambo, F. ; Wilkinson, R.J. ; Coin, L.J. ; Levin, M. ;
PLoS Med, 2013; 10(10):e1001538
BCG Vaccination Induces Different Cytokine Profiles Following Infant BCG Vaccination in the UK and Malawi.
Lalor, M.K. ; Floyd, S. ; Gorak-Stolinska, P. ; Ben-Smith, A. ; Weir, R.E. ; Smith, S.G. ; Newport, M.J. ; Blitz, R. ; Mvula, H. ; Branson, K. ; McGrath, N. ; Crampin, A.C. ; Fine, P.E. ; Dockrell, H.M. ;
J Infect Dis, 2011; 204(7):1075-85
BCG-induced increase in interferon-gamma response to mycobacterial antigens and efficacy of BCG vaccination in Malawi and the UK: two randomised controlled studies
Black, G. F.; Weir, R. E.; Floyd, S.; Bliss, L.; Warndorff, D. K.; Crampin, A. C.; Ngwira, B.; Sichali, L.; Nazareth, B.; Blackwell, J. M.; Branson, K.; Chaguluka, S. D.; Donovan, L.; Jarman, E.; King, E.; Fine, P. E. M.; Dockrell, H. M.
Lancet, 2002; 359(9315):1393-1401
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