Dr Brian deSouza MPhil PhD
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Brian de Souza graduated in London with degrees in Biochemistry and Immunology. He then he studied for an MPhil and PhD in parasite immunology in the Department of Immunology at University College London Medical School. He has worked on malaria since 1977 and has extensive expertise in immunology and immunopathology of malaria, with particular interests in parasite-derived molecules (“toxins”) that drive the inflammatory response during infection. Since 1992 his main interests have been in developing novel drug or vaccine based therapies for severe malaria. Brian is a Senior Lecturer at University College London Medical School and he holds an honorary Senior Lectureship at the London School of Hygiene and Tropical Medicine. He joined the School as a visiting scientist in 2002
Module organizer of LSHTM DL IDM503 Malaria
Lecturer on undergraduate medical and ungraduate and postgraduate biomedical science degree courses at UCL
Current studies are involved with understanding the host-parasite interactions during malaria associated lung damage. Specifically, the interactions that enable parasite and leukocyte cytoadhesion to human lung endothelium in vitro under both static and under physiological flow conditions. Together with collaborators at the Liverpool School of Tropical Medicine and the University of Malawi Medical School, the study will be extended to include histopathological and transcription signal analysis of human postmortem lung tissue.
- T-cell immunology
Disease and Health Conditions
- Malaria Toxins
Parasite-Derived Plasma Microparticles Contribute Significantly to Malaria Infection-Induced Inflammation through Potent Macrophage Stimulation.
Couper, K.N.; Barnes, T.; Hafalla, J.C.; Combes, V.; Ryffel, B.; Secher, T.; Grau, G.E.; Riley, E.M.; de Souza, J.B.;
PLoS Pathog, 2010; 6(1):e1000744
Oral activated charcoal prevents experimental cerebral malaria in mice and in a randomized controlled clinical trial in man did not interfere with the pharmacokinetics of parenteral artesunate.
de Souza, J.B.; Okomo, U.; Alexander, N.D.; Aziz, N.; Owens, B.M.; Kaur, H.; Jasseh, M.; Muangnoicharoen, S.; Sumariwalla, P.F.; Warhurst, D.C.; Ward, S.A.; Conway, D.J.; Ulloa, L.; Tracey, K.J.; Foxwell, B.M.; Kaye, P.M.; Walther, M.;
PLoS One, 2010; 5(4):e9867
Neutralization of malaria GPI in vitro by serum IgG from malaria exposed individuals.
de Souza, J.B.; Runglall, M.; Corran, P.H.; Okell, L.C.; Kumar, S.; Gowda, D.C.; Couper, K.N.; Riley, E.M.;
Infect Immun, 2010; 78(9):3920-9
Essential Role for IL-27 Receptor Signaling in Prevention of Th1-Mediated Immunopathology during Malaria Infection
Findlay, E.G.; Greig, R.; Stumhofer, J.S.; Hafalla, J.C.R.; de Souza, J.B.; Saris, C.J.; Hunter, C.A.; Riley, E.M.; Couper, K.N.
Journal of Immunology, 2010; 185(4):2482-2492
Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease.
Brian de Souza, J.; Hafalla, J.C.; Riley, E.M.; Couper, K.N.;
Parasitology, 2009; 137(5):755-72
IL-10 from CD4CD25Foxp3CD127 Adaptive Regulatory T Cells Modulates Parasite Clearance and Pathology during Malaria Infection.
Couper, K.N.; Blount, D.G.; Wilson, M.S.; Hafalla, J.C.; Belkaid, Y.; Kamanaka, M.; Flavell, R.A.; de Souza, J.B.; Riley, E.M.;
PLoS Pathog, 2008; 4(2):e1000004
Concurrent gastro-intestinal nematode infection does not alter the development of experimental cerebral malaria.
de Souza, JB.; Helmby, H.;
Microbes Infect, 2008; 10(8):916-21
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