Dr Brian deSouza MPhil PhD

Honorary Senior Lecturer Module Organizer for Distance learning IDM503 Malaria


Brian de Souza graduated in London with degrees in Biochemistry and Immunology. He then he studied for an MPhil and PhD in parasite immunology in the Department of Immunology at University College London Medical School. He has worked on malaria since 1977 and has extensive expertise in immunology and immunopathology of malaria, with particular interests in parasite-derived molecules (“toxins”) that drive the inflammatory response during infection. Since 1992 his main interests have been in developing novel drug or vaccine based therapies for severe malaria. Brian is a Senior Lecturer at University College London Medical School and he holds an honorary Senior Lectureship at the London School of Hygiene and Tropical Medicine. He joined the School as a visiting scientist in 2002




Module organizer of LSHTM DL IDM503 Malaria

Lecturer on undergraduate medical and ungraduate and postgraduate biomedical science degree courses at UCL


 Current studies are involved with understanding the host-parasite interactions during malaria associated lung damage.  Specifically, the interactions that enable parasite and leukocyte cytoadhesion to human lung endothelium in vitro under both static and under physiological flow conditions. Together with collaborators at the Liverpool School of Tropical Medicine and the University of Malawi Medical School, the study will be extended to include histopathological and transcription signal analysis of human postmortem lung tissue.


Research areas

  • T-cell immunology


  • Immunology
  • Immunopathology

Disease and Health Conditions

  • Malaria

Other interests

  • Malaria Toxins
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