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Dr Brian deSouza

MPhil PhD

Honorary Senior Lecturer
Module Organizer for Distance learning IDM503 Malaria

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Affiliations

Faculty of Infectious and Tropical Diseases
Immunology and Infection Department

Teaching

Module organizer of LSHTM DL IDM503 Malaria

Lecturer on undergraduate medical and ungraduate and postgraduate biomedical science degree courses at UCL

Research

 Current studies are involved with understanding the host-parasite interactions during malaria associated lung damage.  Specifically, the interactions that enable parasite and leukocyte cytoadhesion to human lung endothelium in vitro under both static and under physiological flow conditions. Together with collaborators at the Liverpool School of Tropical Medicine and the University of Malawi Medical School, the study will be extended to include histopathological and transcription signal analysis of human postmortem lung tissue.

 

Research Area
T-cell immunology
Discipline
Immunopathology
Immunology
Disease and Health Conditions
Malaria

Selected Publications

Parasite-Derived Plasma Microparticles Contribute Significantly to Malaria Infection-Induced Inflammation through Potent Macrophage Stimulation.
Couper, K.N.; Barnes, T.; Hafalla, J.C.; Combes, V.; Ryffel, B.; Secher, T.; Grau, G.E.; Riley, E.M.; de Souza, J.B.;
PLoS Pathog
Oral activated charcoal prevents experimental cerebral malaria in mice and in a randomized controlled clinical trial in man did not interfere with the pharmacokinetics of parenteral artesunate.
de Souza, J.B.; Okomo, U.; Alexander, N.D.; Aziz, N.; Owens, B.M.; Kaur, H.; Jasseh, M.; Muangnoicharoen, S.; Sumariwalla, P.F.; Warhurst, D.C.; Ward, S.A.; Conway, D.J.; Ulloa, L.; Tracey, K.J.; Foxwell, B.M.; Kaye, P.M.; Walther, M.;
PLoS One
Neutralization of malaria GPI in vitro by serum IgG from malaria exposed individuals.
de Souza, J.B.; Runglall, M.; Corran, P.H.; Okell, L.C.; Kumar, S.; Gowda, D.C.; Couper, K.N.; Riley, E.M.;
Infect Immun
Essential Role for IL-27 Receptor Signaling in Prevention of Th1-Mediated Immunopathology during Malaria Infection
Findlay, E.G.; Greig, R.; Stumhofer, J.S.; Hafalla, J.C.R.; de Souza, J.B.; Saris, C.J.; Hunter, C.A.; Riley, E.M.; Couper, K.N.
Journal of Immunology
Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease.
Brian de Souza, J.; Hafalla, J.C.; Riley, E.M.; Couper, K.N.;
Parasitology
IL-10 from CD4CD25Foxp3CD127 Adaptive Regulatory T Cells Modulates Parasite Clearance and Pathology during Malaria Infection.
Couper, K.N.; Blount, D.G.; Wilson, M.S.; Hafalla, J.C.; Belkaid, Y.; Kamanaka, M.; Flavell, R.A.; de Souza, J.B.; Riley, E.M.;
PLoS Pathog
See all Dr Brian deSouza's Publications