Brian deSouza MPhil PhD
- Room 234
- LSHTM
- Keppel Street
- London
- WC1E 7HT
- T: 020 7927 2690
- F: 020 7927 2807
Brian de Souza started work on malaria at The Middlesex Hospital Medical School (University of London) where he completed his MPhil in 1984. In 1992 he completed his PhD at University College London Medical School on vaccines against rodent blood-stage malaria. He then worked on immunity and immunopathology of malaria at UCL Medical School where he is currently Senior Lecturer. He joined the School as a visiting scientist in 2002.
Affiliation
Teaching
Module organizer of LSHTM DL ID503 course
Lecturer on undergraduate medical and biomedical science degree courses at UCL
Research
Current studies are aimed at developing novel drug or vaccine based therapies for severe malaria, in particular, cerebral malaria. The strategy is based on a two-pronged approach of complementary animal and human studies. Firstly, to identify the risk factors involved in the evolution of cerebral syndrome and secondly, to clarify the function of anti-toxin antibodies in acute and immune serum in view of the inflammation-inducing role of toxins such as glycosylphosphatidylinositol (GPI).
Research areas
- T-cell immunology
Disciplines
- Immunology
- Immunopathology
Disease and Health Conditions
- Malaria
Other interests
- Malaria Toxins
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Selected publications
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Parasite-Derived Plasma Microparticles Contribute Significantly to Malaria Infection-Induced Inflammation through Potent Macrophage Stimulation.
Couper, K.N.; Barnes, T.; Hafalla, J.C.; Combes, V.; Ryffel, B.; Secher, T.; Grau, G.E.; Riley, E.M.; de Souza, J.B.;
PLoS Pathog, 2010; 6(1):e1000744
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Oral activated charcoal prevents experimental cerebral malaria in mice and in a randomized controlled clinical trial in man did not interfere with the pharmacokinetics of parenteral artesunate.
de Souza, J.B.; Okomo, U.; Alexander, N.D.; Aziz, N.; Owens, B.M.; Kaur, H.; Jasseh, M.; Muangnoicharoen, S.; Sumariwalla, P.F.; Warhurst, D.C.; Ward, S.A.; Conway, D.J.; Ulloa, L.; Tracey, K.J.; Foxwell, B.M.; Kaye, P.M.; Walther, M.;
PLoS One, 2010; 5(4):e9867
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Neutralization of malaria GPI in vitro by serum IgG from malaria exposed individuals.
de Souza, J.B.; Runglall, M.; Corran, P.H.; Okell, L.C.; Kumar, S.; Gowda, D.C.; Couper, K.N.; Riley, E.M.;
Infect Immun, 2010;
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Essential Role for IL-27 Receptor Signaling in Prevention of Th1-Mediated Immunopathology during Malaria Infection
Findlay, E.G.; Greig, R.; Stumhofer, J.S.; Hafalla, J.C.R.; de Souza, J.B.; Saris, C.J.; Hunter, C.A.; Riley, E.M.; Couper, K.N.
Journal of Immunology, 2010; 185(4):2482-2492
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Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease.
Brian de Souza, J.; Hafalla, J.C.; Riley, E.M.; Couper, K.N.;
Parasitology, 2009; 137(5):755-72
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IL-10 from CD4CD25Foxp3CD127 Adaptive Regulatory T Cells Modulates Parasite Clearance and Pathology during Malaria Infection.
Couper, K.N.; Blount, D.G.; Wilson, M.S.; Hafalla, J.C.; Belkaid, Y.; Kamanaka, M.; Flavell, R.A.; de Souza, J.B.; Riley, E.M.;
PLoS Pathog, 2008; 4(2):e1000004
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Concurrent gastro-intestinal nematode infection does not alter the development of experimental cerebral malaria.
de Souza, JB.; Helmby, H.;
Microbes Infect, 2008; 10(8):916-21
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TGF-beta(1) released from activated platelets can induce TNF-stimulated human brain endothelium apoptosis: A new mechanism for microvascular lesion during cerebral malaria
Wassmer, S. C.; de Souza, J. B.; Frere, G.; Candal, F. J.; Juhan-Vague, I.; Grau, G. E.
Journal of Immunology, 2006; 176(2):1180-4
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