Dr Jon Cuccui BSc MSc PhD
- Room 204b
- LSHTM
- Keppel Street
- London
- WC1E 7HT
- T: +44 (0) 20 7927 2813
- F: +44 (0) 20 7637 4314
Jon started at the LSHTM in September 2002. He was previously employed at St. Bartholomew's Hospital working on an ancient DNA extraction project. He attempted to extract human and Yersinia pestis DNA from the teeth of suspected plague victims who died in the 14th century. Other projects included looking into the genetic organisation and functional aspects of a putative metabolic island containing cobalamin synthesis and propanediol utilisation operons in Yersinia enterocolitica 8081.
He completed his Ph.D. in Professor Brendan Wren's laboratory carrying out signature tagged mutagenesis on Burkholderia pseudomallei. He completed his first Post Doc carrying out glycoengineering with Francisella tularensis and B. pseudomallei and is now continuing to work within the glycoengineering field. His interests are not only on the application and development of novel protein glycan coupling technologies but also on the biological reasons why bacteria carry such varied glycosylation systems.
Affiliation
Teaching
Medical Microbiology M.Sc. lecturer, tutor, project supervisor, examiner and exam board member
Research
He is working on the O-antigen of Francisella tularensis and characterising the capsular polysaccharide of Burkholderia pseudomallei. He also continues to work on selected mutants identified during his PhD entitled 'The development of a refined signature tagged mutagenesis strategy for the identification of novel virulence determinants and vaccine candidates in Burkholderia pseudomallei.'
He is currently funded by a BBSRC LoLa grant to study various aspects of the epidemiology and pathogenicity of several pig pathogens including Streptococcus suis, Actinobacillus pleuropneumoniae, Haemphilus parasuis and Mycoplasma hyopneumoniae.
Research areas
- Bacteria
- Vaccines
Disciplines
- Bacteriology
- Genetic epidemiology
- Genetics
- Microbiology
- Molecular biology
Disease and Health Conditions
- Infectious disease
Other interests
- Bacterial Infections
- Burkholderia Pseudomallei
- Conjugate Vaccines
- Emerging Infectious Diseases
- Francisella Tularensis
- Glycoengineering
-
Selected publications
-
Characterisation of the Burkholderia pseudomallei K96243 CPS I coding region.
Cuccui, J.; Milne, T.S.; Harmer, N.; George, A.J.; Harding, S.V.; Dean, R.E.; Scott, A.E.; Sarkar-Tyson, M.; Wren, B.W.; Titball, R.W.; Prior, J.L.;
Infect Immun, 2012; 80(3):1209-21
-
Recent developments in bacterial protein glycan coupling technology and glycoconjugate vaccine design.
Terra, V.S.; Mills, D.C.; Yates, L.E.; Abouelhadid, S.; Cuccui, J.; Wren, B.W.;
J Med Microbiol, 2012; 61(Pt 7):919-26
-
Neutrophil extracellular traps exhibit antibacterial activity against Burkholderia pseudomallei and are influenced by bacterial and host factors.
Riyapa, D.; Buddhisa, S.; Korbsrisate, S.; Cuccui, J.; Wren, B.W.; Stevens, M.P.; Ato, M.; Lertmemongkolchai, G.;
Infect Immun, 2012; 80(11):3921-9
-
Global transcriptional profiling of Burkholderia pseudomallei under salt stress reveals differential effects on the Bsa type III secretion system
Pumirat, P.; Cuccui, J.; Stabler, R.A.; Stevens, J.M.; Muangsombut, V.; Singsuksawat, E.; Stevens, M.P.; Wren, B.W.; Korbsrisate, S.
BMC Microbiology, 2010; 10
-
N-linked glycosylation in bacteria: an unexpected application.
Langdon, R.H.; Cuccui, J.; Wren, B.W.;
Future Microbiol, 2009; 4(4):401-12
-
Burkholderia pseudomallei: animal models of infection.
Titball, R.W.; Russell, P.; Cuccui, J.; Easton, A.; Haque, A.; Atkins, T.; Sarkar-Tyson, M.; Harley, V.; Wren, B.; Bancroft, G.J.;
Trans R Soc Trop Med Hyg, 2008; 102 Suppl 1:S111-6
-
Development of signature tagged mutagenesis in Burkholderia pseudomallei to identify genes important in survival and pathogenesis.
Cuccui, J.; Easton, A.; Chu, K.K.; Bancroft, G.J.; Oyston, P.C.; Titball, R.W.; Wren, B.W.;
Infect Immun, 2006; 75(3):1186-95
-
Absence of Yersinia pestis-specific DNA in human teeth from five European excavations of putative plague victims.
Gilbert, M.T.; Cuccui, J.; White, W.; Lynnerup, N.; Titball, R.W.; Cooper, A.; Prentice, M.B.;
Microbiology, 2004; 150(Pt 2):341-54
- → View all Dr Jon Cuccui's publications
