Simon Croft BSc PGCE PhD

Professor of Parasitology / Dean of Faculty

• Affiliation
• Research

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Simon Croft is Professor of Parasitology and Dean of the Faculty of Infectious and Tropical Diseases at the London School of Hygiene & Tropical Medicine. He trained at the Liverpool School of Tropical Medicine and, after post-doctoral periods in the laboratory researching drug mechanisms and in disease endemic countries working on the transmission of African trypanosomiasis, he moved to research on drug discovery and development. His expertise and knowledge on antimicrobial chemotherapy was developed while working for 5 years with the Wellcome Research Laboratories, Beckenham, UK in the 1980s. Following his return to academia, Simon focused his research on the identification and evaluation of novel drugs and formulations for the treatment of leishmaniasis, malaria, human African trypanosomiasis (sleeping sickness) and American trypanosomiasis (Chagas disease). This research included projects on miltefosine, AmBisome and topical paromomycin, all of which reached clinical trials for the treatment of leishmaniasis, and many others with academic and industry partners. His work on anti-malarials has included several MMV supported discovery and pre-clinical projects. Current research interests include drug – immune response interactions and PK PD relationships. From 2004 to 2007 Simon was the first R & D Director of the Drugs for Neglected Diseases Initiative (DNDi), Geneva.

 

Affiliation

• Immunology and Infection Department
• Faculty of Infectious and Tropical Diseases

Research

Current research programmes on antimalarial, antileishmanial and antitrypanosomal drug identification, evaluation and development are supported by EU FP7 and MMV. Other projects - on a vaccine for leishmaniasis is supported by EU FP7, on topical formulations for the cutaneous leishmaniases by the Sir Halley Stewart Trust and Heptagon, and on models for 2nd stage African trypanosomiasis by the Bill and Melinda Gates Foundation.

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