Simon Croft BSc PGCE PhD FSB

Professor of Parasitology

Simon Croft's Background


Simon Croft is Professor of Parasitology and Dean of the Faculty of Infectious and Tropical Diseases at the London School of Hygiene & Tropical Medicine. He trained at the Liverpool School of Tropical Medicine and, after post-doctoral periods in the laboratory researching drug mechanisms and in disease endemic countries working on the transmission of African trypanosomiasis, he moved to research on drug discovery and development. His expertise and knowledge on antimicrobial chemotherapy was developed while working for 5 years with the Wellcome Research Laboratories, Beckenham, UK in the 1980s. Following his return to academia, Simon focused his research on the identification and evaluation of novel drugs and formulations for the treatment of leishmaniasis, malaria, human African trypanosomiasis (sleeping sickness) and American trypanosomiasis (Chagas disease). This research included projects on miltefosine, AmBisome and topical paromomycin, all of which reached clinical trials for the treatment of leishmaniasis, and many others with academic and industry partners. His work on anti-malarials has included several MMV supported discovery and pre-clinical projects. Current research interests include drug – immune response interactions and PK PD relationships. From 2004 to 2007 Simon was the first R & D Director of the Drugs for Neglected Diseases Initiative (DNDi), Geneva.


Simon Croft's Affiliation

Simon Croft's Research

Current research programmes on antileishmanial and antitrypanosomal drug identification, evaluation and development are supported by MRC, Gates Foundation, GSK Open Lab Foundation and DNDi. One major research focus is on PK PD relationships and the development of predictive models, and another on improved pharmaceutical formulations. Projects on topical formulations for the cutaneous leishmaniases are supported from a number of sources.

Research areas

  • Chemotherapy
  • Drug discovery and development
  • Parasites
  • Pharmacokinetics
  • Protozoa
  • Trypanosomes
  • Vaccines


  • Cell biology
  • Parasitology
  • Pharmacology

Disease and Health Conditions

  • African trypanosomiasis
  • Chagas Disease
  • Leishmaniasis
  • Malaria
  • Neglected Tropical Diseases (NTDs)
  • Skin disease


  • World


  • India
  • Malaysia

Other interests

  • Antiprotozoal Drug Discovery
  • Drug Efficacy
  • Drug Measurement
  • Emerging Infectious Diseases
  • Infectious Diseases
  • Leishmania donovani
  • Macrophage
  • Neglected Tropical Diseases
  • Opportunistic Infectious Diseases
  • Parasite Clearance
  • Pharmaceutical Industry
  • Trypansoma cruzi
  • international partnerships
  • parasites
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