Dr Sharon Cox Bsc Msc PhD

- Muhimbili Wellcome Programe
- Muhimbili University of Healh & Allied Sciences
- Dar es Salaam
- T: +44 (0) 207 927 2979
- F: +44 (0) 207 958 8111
I graduated from University College London with a BSc. (Biochemistry, First Class Hons) in 1996, followed by a post graduate teaching qualification (1997), a Masters in Public Health Nutrition at LSHTM (1998) and finally a PhD, also at LSHTM (2003). I joined the public Health Nutrition Unit (now merged to become the NPHIRU) in 2002 as a member of the MRC International Nutrition Group, headed by Professor Andrew Prentice.
Affiliation
Teaching
I teach some sessions within the MSc in Public Health Nutrition at LSHTM and I am a tutor for the advanced unit ID202 “Nutrition and Infection” for the distance learning MSc in Infectious Diseases.
Research
I am currently based in Dar es Salaam Tanzania within the Muhimbili Wellcome Programme supported by a Wellcome Trust Strategic Award. My research is focussed on nutritional and genetic modulation of sickle cell disease (SCD). I am the Principal investigator of a Wellcome Trust funded clinical trial of a nutraceutical intervention in children with SCD with primary endpoints of growth and improved vascular function, due to start enrolment in 2012. Within the MWP I head-up the developing research programme of nutrition and physiology, most of which is nested within the Muhimbili Sickle Cohort of over 2,000 patients in routine follow-up. My main collaborators in MWP are Dr Julie Makani, (Muhimbili University of Health & Allied Sciences & University of Oxford) & Professor Charles Newton (University of Oxford & KEMRI-Kilifi, Kenya).
I also continue to collaborate with other members of the MRC International Nutrition Group on projects based in The Gambia and elsewhere.
Research areas
- Maternal health
- Micronutrients
Disciplines
- Biochemistry
- Epidemiology
- Genetic epidemiology
- Genetics
- Immunoepidemiology
- Immunology
- Nutrition
Disease and Health Conditions
- Cardiovascular disease
- Eye diseases
- Infectious disease
- Malaria
- Malnutrition
Other interests
- Anaemia
- Iron
- Nutrient-gene Interactions
- sickle cell disease
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Selected publications
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Mortality in Sickle Cell Anemia in Africa: A Prospective Cohort Study in Tanzania
Makani, J.; Cox, S.E.; Soka, D.; Komba, A.N.; Oruo, J.; Mwamtemi, H.; Magesa, P.; Rwezaula, S.; Meda, E.; Mgaya, J.; Lowe, B.; Muturi, D.; Roberts, D.J.; Williams, T.N.; Pallangyo, K.; Kitundu, J.; Fegan, G.; Kirkham, F.J.; Marsh, K.; Newton, C.R.
Plos One, 2011; 6(2)
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Nutritional status, hospitalization and mortality among patients with sickle cell anemia in Tanzania.
Cox, S.E. ; Makani, J. ; Fulford, A.J. ; Komba, A.N. ; Soka, D. ; Williams, T.N. ; Newton, C.R. ; Marsh, K. ; Prentice, A.M. ;
Haematologica, 2011; 96(7):948-53
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Global arginine bioavailability in Tanzanian sickle cell anaemia patients at steady-state: a nested case control study of deaths versus survivors.
Cox, S.E. ; Makani, J. ; Komba, A.N. ; Soka, D. ; Newton, C.R. ; Kirkham, F.J. ; Prentice, A.M. ;
Br J Haematol, 2011;
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Low folate status and indoor pollution are risk factors for endemic optic neuropathy in Tanzania.
Hodson, K.E. ; Bowman, R.J. ; Mafwiri, M. ; Wood, M. ; Mhoro, V. ; Cox, S.E. ;
Br J Ophthalmol, 2011;
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Haptoglobin and sickle cell polymorphisms and risk of active trachoma in gambian children.
Savy, M.; Hennig, B.J.; Doherty, C.P.; Fulford, A.J.; Bailey, R.; Holland, M.J.; Sirugo, G.; Rockett, K.A.; Kwiatkowski, D.P.; Prentice, A.M.; Cox, S.E.;
PLoS One, 2010; 5(6):e11075
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Genetics of fetal hemoglobin in Tanzanian and British patients with sickle cell anemia.
Makani, J.; Menzel, S.; Nkya, S.; Cox, S.E.; Drasar, E.; Soka, D.; Komba, A.N.; Mgaya, J.; Rooks, H.; Vasavda, N.; Fegan, G.; Newton, C.R.; Farrall, M.; Thein, S.L.;
Blood, 2010;
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Nocturnal haemoglobin oxygen saturation variability is associated with vitamin C deficiency in Tanzanian children with sickle cell anaemia.
Cox, S.; L'esperance, V.; Makani, J.; Soka, D.; Hill, C.; Kirkham, F.;
Acta Paediatr, 2010;
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Malaria in patients with sickle cell anemia: burden, risk factors and outcome at outpatient clinic and during hospitalization.
Makani, J.K.; Komba, A.N.; Cox, S.E.; Oruo, J.; Mwamtemi, K.; Kitundu, J.; Magesa, P.; Rwezaula, S.; Meda, E.; Mgaya, J.; Pallangyo, K.; Okiro, E.; Muturi, D.; Newton, C.R.; Fegan, G.; Marsh, K.; Williams, T.N.;
Blood, 2009; 115(2):215-20
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