Kevin Couper BSc PhD
- Room 233
- LSHTM
- Keppel Street
- London
- WC1E 7HT
- T: +44 (0)207 927 2690
I obtained a BSc (hons) in Biochemistry and Immunology from the University of Strathclyde (Glasgow) in 1999. I stayed at Strathclyde to complete a PhD on the function of IgM during Toxoplasma gondii and Plasmodium chabaudi infections. After finishing my PhD in 2003 I moved to the Trudeau Institute (USA) to undertake a post-doctoral fellowship investigating the importance of immune-regulation during Toxoplasma gondii infection. In 2005 I moved to LSHTM as a post-doctoral fellow in Professor Eleanor Riley's lab where I studied protective and regulatory immune responses during malaria infection. I was awarded an MRC Career Development Award in 2009 to define the parasitological and immunological basis of cerebral pathology during murine experimental cerebral malaria.
Affiliation
Teaching
I teach on the Immunology of Infectious Diseases and Immunology of Parasitic Infections MSc modules.
Research
The main focus of my research is to understand the pathways controlling the priming and differentiation of effector and regulatory T cell responses during malaria infection, and how the interplay between these two populations determines the outcome of disease. A secondary aim is to understand the pathogenesis of experimental cerebral malaria.
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Selected publications
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Parasite-Derived Plasma Microparticles Contribute Significantly to Malaria Infection-Induced Inflammation through Potent Macrophage Stimulation.
Couper, K.N.; Barnes, T.; Hafalla, J.C.; Combes, V.; Ryffel, B.; Secher, T.; Grau, G.E.; Riley, E.M.; de Souza, J.B.;
PLoS Pathog, 2010; 6(1):e1000744
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Essential Role for IL-27 Receptor Signaling in Prevention of Th1-Mediated Immunopathology during Malaria Infection
Findlay, E.G.; Greig, R.; Stumhofer, J.S.; Hafalla, J.C.R.; de Souza, J.B.; Saris, C.J.; Hunter, C.A.; Riley, E.M.; Couper, K.N.
Journal of Immunology, 2010; 185(4):2482-2492
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Anti-CD25 antibody-mediated depletion of effector T cell populations enhances susceptibility of mice to acute but not chronic Toxoplasma gondii infection.
Couper, K.N.; Lanthier, P.A.; Perona-Wright, G.; Kummer, L.W.; Chen, W.; Smiley, S.T.; Mohrs, M.; Johnson, L.L.;
J Immunol, 2009; 182(7):3985-94
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Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease.
Brian de Souza, J.; Hafalla, J.C.; Riley, E.M.; Couper, K.N.;
Parasitology, 2009; 137(5):755-72
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IL-10 from CD4CD25Foxp3CD127 Adaptive Regulatory T Cells Modulates Parasite Clearance and Pathology during Malaria Infection.
Couper, K.N.; Blount, D.G.; Wilson, M.S.; Hafalla, J.C.; Belkaid, Y.; Kamanaka, M.; Flavell, R.A.; de Souza, J.B.; Riley, E.M.;
PLoS Pathog, 2008; 4(2):e1000004
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IL-10: The master regulator of immunity to infection
Couper, K.N.; Blount, D.G.; Riley, E.M.
Journal of Immunology, 2008; 180(9):5771-5777
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Incomplete Depletion and Rapid Regeneration of Foxp3+ Regulatory T Cells Following Anti-CD25 Treatment in Malaria-Infected Mice.
Couper, K.N.; Blount, D.G.; de Souza, J.B.; Suffia, I.; Belkaid, Y.; Riley, E.M.;
J Immunol, 2007; 178(7):4136-46
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Macrophage-mediated but IFN-{gamma}-independent innate immune responses control the primary wave of Plasmodium yoelii parasitaemia.
Couper, K.N.; Blount, D.G.; Hafalla, J.C.; van Rooijen, N.; de Souza, J.B.; Riley, E.M.;
Infect Immun, 2007; 75(12):5806-18
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