Dr Liz Corbett BA MB BChir FRCP PhD

Reader in Infectious and Tropical Diseases

• Affiliation
• Teaching
• Research
• Publications

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Liz Corbett is a Clinical Epidemiologist, who trained as a specialist Infectious Diseases in the UK. She has been in full time research at LSHTM since a Wellcome Trust Training Fellowship in 1996, with a short break to complete clinical training in 2000. Liz was funded by two successive Wellcome Trust Grants to work full time in Zimbabwe from 2001 to 2009, having also spent 3 years in South Africa for her PhD, and has moved to Blantyre, Malawi in 2009 also with support from Wellcome Trust. She currently holds a Wellcome Trust Senior Research Fellowship in Clinical Science and is working on TB / HIV research from Malawi-Liverpool-Wellcome Clinical Research Programme, Blantyre, Malawi. Liz is a member of the Executive Committee of the Consortium to Respond Effectively to the AIDS/TB Epidemic (CREATE) and has longstanding collaborative links with WHO, including current membership of the Strategic Technical Advisory Group of Stop TB.

Affiliation

• Department of Clinical Research

Teaching

Liz contributes to the DBL MSc in Infectious Diseases, but does not teach face-to-face in London.

Research

My main research interest is in improving TB control in high HIV populations, with a special focus on exploring novel public health strategies with potential to increase access to TB diagnosis and treatment, with the focus on community-level diagnostic access interventions.  Following highly promising results from a cluster-randomised trial of intensified TB case-finding in Harare, Zimbabwe, I am now evaluating long-term trends in TB case-notificiation rates following the introduction of  intensified TB case-finding in Blantyre, Malawi.  This study has a cluster-randomised trial of intensified TB prevalent provided as the option to self-test for HIV under supervison of a resident community counsellor with facilitated access to HIV care including isoniazid preventive therapy.  We also have a cluster randomised trial with Johns Hopkins University investigating the impact on survival at one year of introducing new TB diagnostics into the initial screening algorithm for people with newly diagnosed HIV infection in Thyolo District, Malawi. My collaborative work includes mathematical modelling at London School, and health economics and social science with Liverpool University.

An additional research interest with Dr Rashida Ferrand concerns the clinical epidemiology of older children and adolescents who are long-term survivors of mother-to-child HIV transmission in Southern Africa. There is considerable anecdotal evidence of an emerging epidemic of infected young people in Southern Africa, where the HIV epidemic has been severe for over a decade.

• Selected publications

• The Uptake and Accuracy of Oral Kits for HIV Self-Testing in High HIV Prevalence Setting: A Cross-Sectional Feasibility Study in Blantyre, Malawi

  Choko, A.T.; Desmond, N.; Webb, E.L.; Chavula, K.; Napierala-Mavedzenge, S.; Gaydos, C.A.; Makombe, S.D.; Chunda, T.; Squire, S.B.; French, N.; Mwapasa, V.; Corbett, E.L.

  Plos Medicine, 2011; 8(10):e1001102

• Causes of acute hospitalization in adolescence: burden and spectrum of HIV-related morbidity in a country with an early-onset and severe HIV epidemic: a prospective survey.

  Ferrand, R.A.; Bandason, T.; Musvaire, P.; Larke, N.; Nathoo, K.; Mujuru, H.; Ndhlovu, C.E.; Munyati, S.; Cowan, F.M.; Gibb, D.M.; Corbett, E.L.;

  PLoS Med, 2010; 7(2):e1000178

• Provider-initiated symptom screening for tuberculosis in Zimbabwe: diagnostic value and the effect of HIV status.

  Corbett, E.L.; Zezai, A.; Cheung, Y.B.; Bandason, T.; Dauya, E.; Munyati, S.S.; Butterworth, A.E.; Rusikaniko, S.; Churchyard, G.J.; Mungofa, S.; Hayes, R.J.; Mason, P.R.;

  Bull World Health Organ, 2010; 88(1):13-21

• Comparison of two active case-finding strategies for community-based diagnosis of symptomatic smear-positive tuberculosis and control of infectious tuberculosis in Harare, Zimbabwe (DETECTB): a cluster-randomised trial.

  Corbett, E.L.; Bandason, T.; Duong, T.; Dauya, E.; Makamure, B.; Churchyard, G.J.; Williams, B.G.; Munyati, S.S.; Butterworth, A.E.; Mason, P.R.; Mungofa, S.; Hayes, R.J.;

  Lancet, 2010; 376(9748):1244-53

• Epidemiology of tuberculosis in a high HIV prevalence population provided with enhanced diagnosis of symptomatic disease

  Corbett, E.L.; Bandason, T.; Cheung, Y.B.; Munyati, S.; Godfrey-Faussett, P.; Hayes, R.; Churchyard, G.; Butterworth, A.; Mason, P.

  Plos Medicine, 2007; 4(1):164-172

• Tuberculosis in sub-Saharan Africa: opportunities, challenges, and change in the era of antiretroviral treatment.

  Corbett, E.L.; Marston, B.; Churchyard, G.J.; De Cock, K.M.;

  Lancet, 2006; 367(9514):926-37

• Uptake of Workplace HIV Counselling and Testing: A Cluster-Randomised Trial in Zimbabwe.

  Corbett, E.L.; Dauya, E.; Matambo, R.; Cheung, Y.B.; Makamure, B.; Bassett, M.T.; Chandiwana, S.; Munyati, S.; Mason, P.R.; Butterworth, A.E.; Godfrey-Faussett, P.; Hayes, R.J.;

  PLoS Med, 2006; 3(7):e238

• The growing burden of tuberculosis: global trends and interactions with the HIV epidemic

  Corbett, E. L.; Watt, C. J.; Walker, N.; Maher, D.; Williams, B. G.; Raviglione, M. C.; Dye, C.

  Archives of Internal Medicine, 2003; 163(9):1009-21

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