Dr Jackie Cliff BA MSc PhD
- Room 236B
- LSHTM
- Keppel Street
- London
- WC1E 7HT
- T: 020 7612 7833
After obtaining my BA degree in Physiological Sciences from St Anne's College, University of Oxford, I completed the MSc in Immunology of Infectious Diseases at LSHTM. I studied for my PhD with Gerry Klaus at the National Institute for Medical Research, investigating the autocrine regulation of murine B cells. I joined LSHTM as a post-doctoral research fellow with Prof. Hazel Dockrell in 1999.
Affiliation
Teaching
I am the Course Content Director for the Distance-Learning MSc in Infectious Diseases, and am also the module organiser for the Tuberculosis module on this course. I also teach on the London-based Immunology of Infectious Diseases course.
Research
I am interested in developing markers of immunity against tuberculosis, to be developed into surrogates of vaccine and drug efficacy and used in future clinical trials. I am currently investigating gene expression profiles in TB patients using Affymetrix GeneChip technology: this project is in collaboration with researchers at the University of Stellenbosch in South Africa, and is funded by the EDCTP. I am also developing field-friendly assays to measure cytotoxic CD8+ T cell induction.
Research areas
- Diagnostics
- Drug discovery and development
- T-cell immunology
- Vaccines
Disciplines
- Genomics
- Immunology
- Molecular biology
Disease and Health Conditions
- Infectious disease
- Tuberculosis
Regions
- Sub-Saharan Africa (all income levels)
Countries
- Pakistan
- South Africa
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Selected publications
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Biogenesis of secretory organelles during B cell differentiation.
Kirk, S.J.; Cliff, J.M.; Thomas, J.A.; Ward, T.H.;
J Leukoc Biol, 2010; 87(2):245-55
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CCL2 responses to Mycobacterium tuberculosis are associated with disease severity in tuberculosis.
Hasan, Z. ; Cliff, J.M. ; Dockrell, H.M. ; Jamil, B. ; Irfan, M. ; Ashraf, M. ; Hussain, R. ;
PLoS One, 2009; 4(12):e8459
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Gene-expression patterns in whole blood identify subjects at risk for recurrent tuberculosis.
Mistry, R.; Cliff, J.M.; Clayton, C.L.; Beyers, N.; Mohamed, Y.S.; Wilson, P.A.; Dockrell, H.M.; Wallace, D.M.; Helden, P.D.; Duncan, K.; Lukey, P.T.;
J Infect Dis, 2007; 195(3):357-65
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Strain-dependent Variation in BCG-induced Human T cell Activation and IFN-{gamma} Production in vitro.
Aguirre-Blanco, A.M.; Lukey, P.T.; Cliff, J.M.; Dockrell, H.M.;
Infect Immun, 2007; 75(6):3197-201
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Extended Culture Enhances Sensitivity of Interferon-{gamma} Assay for Latent Mycobacterium tuberculosis infection.
Cehovin, A.; Cliff, J.M.; Hill, P.C.; Brookes, R.H.; Dockrell, H.M.;
Clin Vaccine Immunol, 2007; 14(6):796-8
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Differential Gene Expression Identifies Novel Markers of CD4(+) and CD8(+) T Cell Activation Following Stimulation by Mycobacterium tuberculosis.
Cliff, J.M.; Andrade, I.N.; Mistry, R.; Clayton, C.L.; Lennon, M.G.; Lewis, A.P.; Duncan, K.; Lukey, P.T.; Dockrell, H.M.;
J Immunol , 2004; 173(1):485-93
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