Dr Jackie Cliff BA MSc PhD
- Jackie Cliff's Contacts
- Room 237
- Keppel Street
- WC1E 7HT
- T: 020 7927 2295
After obtaining my BA degree in Physiological Sciences from St Anne's College, University of Oxford, I completed the MSc in Immunology of Infectious Diseases at LSHTM. I studied for my PhD with Gerry Klaus at the National Institute for Medical Research, investigating the autocrine regulation of murine B cells. I joined LSHTM as a post-doctoral research fellow with Prof. Hazel Dockrell in 1999, investigating immune responses in tuberculosis.
I am the Programme Content Director for the Distance-Learning Masters Certificate/Diploma/MSc in Infectious Diseases, and am the module organiser for the Tuberculosis module on this course. I also teach on the London-based Immunology of Infectious Diseases MSc course.
I am interested in biomarkers of tuberculosis treatment-response, which would facilitate clinical trials of new TB therapies. We are characterising changes in human blood gene expression patterns which correlate with successful cure or with treatment-failure /relapse. We are also investigating how these are affected by co-morbidities, such as HIV/TB or helminth/TB co-infection. Candidate host gene expression panels from microarray and/or RNASeq transcriptomic datasets are being developed into more field-friendly tools for validation as potential biomarkers of TB treatment outcome.
As part of the TANDEM research consortium, we are investigating the causal mechanism underlying the enhanced susceptibility to TB disease development caused by type 2 diabetes, by analysing gene expression profiles in TB/diabetes co-morbid patients compared to uncomplicated TB patients.
I also collaborate with the CURE-ME group to investigate disease pathogenesis in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome.
- Drug discovery and development
- T-cell immunology
- Molecular biology
Disease and Health Conditions
- Chronic Fatigue Syndrome
- Infectious disease
- East Asia & Pacific (all income levels)
- Europe & Central Asia (all income levels)
- European Union
- Latin America & Caribbean (developing only)
- South Asia
- Sub-Saharan Africa (all income levels)
- South Africa
- Bacterial Pathogenesis
- CD8+ T Cells
- Distance Learning
- TB Centre
Primary macrophages and J774 cells respond differently to infection with Mycobacterium tuberculosis.
Andreu, N. ; Phelan, J. ; de Sessions, P.F. ; Cliff, J.M. ; Clark, T.G. ; Hibberd, M.L. ;
Sci Rep, 2017; 7:42225
Excessive Cytolytic Responses Predict Tuberculosis Relapse After Apparently Successful Treatment.
Cliff, J.M.; Cho, J.E.; Lee, J.S.; Ronacher, K.; King, E.C.; van Helden, P.; Walzl, G.; Dockrell, H.M.;
J Infect Dis, 2016; 213(3):485-95
The human immune response to tuberculosis and its treatment: a view from the blood.
Cliff, J.M. ; Kaufmann, S.H. ; McShane, H. ; van Helden, P. ; O'Garra, A. ;
Immunol Rev, 2015; 264(1):88-102
PD-1, PD-L1 and PD-L2 Gene Expression on T-Cells and Natural Killer Cells Declines in Conjunction with a Reduction in PD-1 Protein during the Intensive Phase of Tuberculosis Treatment.
Hassan, S.S. ; Akram, M. ; King, E.C. ; Dockrell, H.M. ; Cliff, J.M. ;
PLoS One, 2015; 10(9):e0137646
Distinct phases of blood gene expression pattern through tuberculosis treatment reflect modulation of the humoral immune response.
Cliff, J.M.; Lee, J.S.; Constantinou, N.; Cho, J.E.; Clark, T.G.; Ronacher, K.; King, E.C.; Lukey, P.T.; Duncan, K.; Van Helden, P.D.; Walzl, G.; Dockrell, H.M.;
J Infect Dis, 2013; 207(1):18-29
Recombinant ESAT-6-CFP10 Fusion Protein Induction of Th1/Th2 Cytokines and FoxP3 Expressing Treg Cells in Pulmonary TB.
Jackson-Sillah, D. ; Cliff, J.M. ; Mensah, G.I. ; Dickson, E. ; Sowah, S. ; Tetteh, J.K. ; Addo, K.K. ; Ottenhoff, T.H. ; Bothamley, G. ; Dockrell, H.M. ;
PLoS One, 2013; 8(6):e68121
Modulation of NKG2D Expression in Human CD8(+) T Cells Corresponding with Tuberculosis Drug Cure.
Hassan, S.S. ; Cho, J.E. ; Akram, M. ; Fielding, K.L. ; Dockrell, H.M. ; Cliff, J.M. ;
PLoS One, 2013; 8(7):e70063
Gene-expression patterns in whole blood identify subjects at risk for recurrent tuberculosis.
Mistry, R.; Cliff, J.M.; Clayton, C.L.; Beyers, N.; Mohamed, Y.S.; Wilson, P.A.; Dockrell, H.M.; Wallace, D.M.; Helden, P.D.; Duncan, K.; Lukey, P.T.;
J Infect Dis, 2007; 195(3):357-65
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