Sian Clarke BSc MSc PhD
- Sian Clarke's Contacts
- Department of Disease Control
- Keppel Street
- WC1E 7HT
- T: + 44 754 552 1491
BSc Biology, University of Sussex, UK; MSc Epidemiology, LSHTM, UK; PhD Malaria Epidemiology, University of Copenhagen, Denmark.
I have been based at LSHTM since 2002, when I came back to London to join the staff of the Gates Malaria Partnership. I am a founder member of the ACT Consortium, an international multidisciplinary research collaboration which conducts research on the deployment of ACTs for malaria treatment. I was awarded a Wellcome Trust Career Development Fellowship in 2009 to investigate the epidemiology and control of malaria in school-aged children, and was based overseas in Senegal for 3 years between 2010-2014.
I have previously worked with the DBL Centre for Health Research and Development, Copenhagen, Denmark, 1995-2002; and the Communicable Disease Surveillance Centre, Health Protection Agency, London, UK, 1988-1995.
I am a member of the London International Development Centre.
MSc Epidemiology: Principles and Practice (distance learning)
MSc Public Health in Developing Countries
MSc Control of Infectious Diseases
I am academic co-ordinator of the MSc module on the "Epidemiology and Control of Malaria"
The primary aim of my research is the development and evaluation of disease control strategies to improve health in low-income countries, with a specific focus on malaria.
My current research investigates (i) the impact of asymptomatic malaria infections on anaemia and cognition; (ii) the epidemiology and control of malaria in school-aged children; and (iii) community-based approaches to improve treatment of malaria and other common childhood infections by community health workers and registered drug shops.
Past research has also examined the spatial epidemiology of malaria in areas of seasonal transmission in West Africa, and low and unstable transmission in the East African Highlands.
I have led numerous intervention studies in sub-Saharan Africa, including randomised trials to evaluate the impact of intermittent parasite clearance in schools; seasonal malaria chemoprevention and nutritional interventions in pre-school children; malaria prevention during pregnancy (IPTp and ITNs); and use of malaria rapid diagnostic tests by CHWs and drug shop vendors.
I have worked in The Gambia, Kenya, Mali, Senegal and Uganda.
- Adolescent health
- Child health
- Complex interventions
- Disease control
- Global Health
- Health systems
- Impact evaluation
- Implementation research
- Maternal health
- Mixed methods
- Private sector
- Public health
- Randomised controlled trials
- Operational research
Disease and Health Conditions
- Infectious disease
- Gambia, The
'Asymptomatic' Malaria: A Chronic and Debilitating Infection That Should Be Treated.
Chen, I.; Clarke, S.E.; Gosling, R.; Hamainza, B.; Killeen, G.; Magill, A.; O'Meara, W.; Price, R.N.; Riley, E.M.;
PLoS Med, 2016; 13(1):e1001942
'It puts life in us and we feel big': shifts in the local health care system during the introduction of rapid diagnostic tests for malaria into drug shops in Uganda.
Hutchinson, E. ; Chandler, C. ; Clarke, S. ; Lal, S. ; Magnussen, P. ; Kayendeke, M. ; Nabirye, C. ; Kizito, J. ; Mbonye, A. ;
Crit Public Health, 2015; 25(1):48-62
A Cluster Randomised Trial Introducing Rapid Diagnostic Tests into Registered Drug Shops in Uganda: Impact on Appropriate Treatment of Malaria.
Mbonye, A.K. ; Magnussen, P. ; Lal, S. ; Hansen, K.S. ; Cundill, B. ; Chandler, C. ; Clarke, S.E. ;
PLoS One, 2015; 10(7):e0129545
Health Facility Utilisation Changes during the Introduction of Community Case Management of Malaria in South Western Uganda: An Interrupted Time Series Approach.
Lal, S. ; Ndyomugenyi, R. ; Alexander, N.D. ; Lagarde, M. ; Paintain, L. ; Magnussen, P. ; Chandramohan, D. ; Clarke, S.E. ;
PLoS One, 2015; 10(9):e0137448
Malaria in school-age children in Africa: an increasingly important challenge
Nankabirwa, J.; Brooker, S.J.; Clarke, S.E.; Fernando, D.; Gitonga, C.W.; Schellenberg, D.; Greenwood, B.
Tropical Medicine & International Health, 2014; 19(11):1294-1309
The impact of intermittent parasite clearance on malaria, anaemia, and cognition in schoolchildren: new evidence from an area of highly seasonal transmission
Clarke, S.; Rouhani, S.; Diarra, S.; Bamadio, M.; Jones, R.; Traore, D.; Jukes, M.; Thuilliez, J.; Sacko, M.; Brooker, S.; Roschnik, N.
Tropical Medicine & International Health, 2013; 18:64-64
Efficacy of malaria prevention during pregnancy in an area of low and unstable transmission: an individually-randomised placebo-controlled trial using intermittent preventive treatment and insecticide-treated nets in the Kabale Highlands, southwestern Uganda
Ndyomugyenyi, R.; Clarke, S.E.; Hutchison, C.L.; Hansen, K.S.; Magnussen, P.
Transactions of the Royal Society of Tropical Medicine and Hygiene, 2011; 105(11):607-616
Effect of intermittent preventive treatment of malaria on health and education in schoolchildren: a cluster-randomised, double-blind, placebo-controlled trial.
Clarke, S.E.; Jukes, M.C.; Njagi, J.K.; Khasakhala, L.; Cundill, B.; Otido, J.; Crudder, C.; Estambale, B.B.; Brooker, S.;
Lancet, 2008; 372(9633):127-38
- → View all Sian Clarke 's publications