Sian Clarke BSc MSc PhD
- Department of Disease Control
- LSHTM
- Keppel Street
- London
- WC1E 7HT
- T: + 221 77 182 35 11
BSc Biology, University of Sussex, UK; MSc Epidemiology, LSHTM, UK; PhD Malaria Epidemiology, University of Copenhagen, Denmark.
I have previously worked with the Communicable Disease Surveillance Centre, Health Protection Agency, London, UK (1988-1995); DBL Centre for Health Research and Development, Copenhagen, Denmark (1995-2002) and the Gates Malaria Partnership, London School of Hygiene and Tropical Medicine, UK (2002-2009).
I currently hold a Wellcome Trust Career Development Fellowship to investigate the epidemiology and control of malaria in school-aged children (2009-2013), and am based overseas in Senegal. I am also a member of the ACT Consortium, which conducts research on the deployment of ACTs for malaria treatment.
Affiliation
Teaching
MSc Epidemiology: Principles and Practice (distance learning)
MSc Public Health in Developing Countries
MSc Control of Infectious Diseases
Research
My past research has examined the spatial epidemiology of malaria in areas of seasonal transmission in West Africa, and low and unstable transmission in the East African Highlands. I have also conducted randomised intervention trials of intermittent preventive treatment (IPT) in schools, and malaria prevention in pregnancy (IPTp and ITNs).
My current research is focussed on (i) the epidemiology and control of malaria in school-aged children, and impact of asymptomatic malaria infections on anaemia and cognition; and (ii) utilisation of RDTs and ACTs by community health workers, and registered drug shops, in home-based management of fever.
I have worked in The Gambia, Kenya, Uganda and most recently Senegal and Mali. I am currently based overseas in Senegal.
Research areas
- Child health
- Complex interventions
- Health outcomes
- Public health
Disciplines
- Epidemiology
Disease and Health Conditions
- Malaria
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Selected publications
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Introducing malaria rapid diagnostic tests at registered drug shops in Uganda: Limitations of diagnostic testing in the reality of diagnosis.
Chandler, C.I. ; Hall-Clifford, R. ; Asaph, T. ; Pascal, M. ; Clarke, S. ; Mbonye, A.K. ;
Soc Sci Med, 2011;
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Efficacy, safety, and tolerability of three regimens for prevention of malaria: a randomized, placebo-controlled trial in ugandan schoolchildren.
Nankabirwa, J.; Cundill, B.; Clarke, S.; Kabatereine, N.; Rosenthal, P.J.; Dorsey, G.; Brooker, S.; Staedke, S.G.;
PLoS One, 2010; 5(10):e13438
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The feasibility of introducing rapid diagnostic tests for malaria in drug shops in Uganda
Mbonye, A.K.; Ndyomugyenyi, R.; Turinde, A.; Magnussen, P.; Clarke, S.; Chandler, C.
Malaria Journal, 2010; 9
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Malaria in African schoolchildren: options for control.
Brooker, S.; Clarke, S.; Snow, R.W.; Bundy, D.A.;
Trans R Soc Trop Med Hyg, 2008; 102(4):304-5
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Effect of intermittent preventive treatment of malaria on health and education in schoolchildren: a cluster-randomised, double-blind, placebo-controlled trial.
Clarke, S.E.; Jukes, M.C.; Njagi, J.K.; Khasakhala, L.; Cundill, B.; Otido, J.; Crudder, C.; Estambale, B.B.; Brooker, S.;
Lancet, 2008; 372(9633):127-38
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Costs and cost-effectiveness of delivering intermittent preventive treatment through schools in western Kenya.
Temperley, M.; Mueller, D.H.; Njagi, J.K.; Akhwale, W.; Clarke, S.E.; Jukes, M.C.; Estambale, B.B.; Brooker, S.;
Malar J, 2008; 7:196
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Efficacy and Cost-Effectiveness of Malaria Prevention in Pregnancy in Low and Unstable Transmission: Results of a Randomised Controlled Trial
Ndyomugyenyi, R.; Clarke, S.E.; Hutchison, C.; Hansen, K.S.; Chandramohan, D.; Magnussen, P.
American Journal of Tropical Medicine and Hygiene, 2008; 79(6):820
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Malaria treatment-seeking behaviour and drug prescription practices in an area of low transmission in Uganda: implications for prevention and control
Ndyomugyenyi, R.; Magnussen, P.; Clarke, S.
Transactions of the Royal Society of Tropical Medicine and Hygiene, 2007; 101(3):209-215
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