Dr Taane Clark BCom MSc DPhil

Reader in Genetic Epidemiology and Statistics

• Affiliation
• Teaching
• Research
• Publications

• 
• K258e
• LSHTM
• Keppel Street
• London
• WC1E 7HT
• T: +44 (0)20 7612 7841

Taane graduated with a D.Phil in Statistics (Oxford) in 2005, and is an experienced biostatistician with expertise in statistical and population genetics. In early 2010 he joined the LSHTM, after holding senior statistician appointments at the Wellcome Trust Sanger Institute (WTSI) and Wellcome Trust Centre for Human Genetics (Oxford), where he focused on the genomic epidemiology of malaria.

Affiliation

• Department of Non-communicable Disease Epidemiology
• Faculty of Epidemiology and Population Health
• Faculty of Infectious and Tropical Diseases
• Department of Pathogen Molecular Biology

Teaching

Pathogen genomics, Genetic epidemiology

Research

His main research interests include the design and analysis of large-scale association studies of infectious diseases in humans, and the investigation of genetic variation in pathogen populations (e.g. Leishmania, Mycobacterium TB (Mtb), Plasmodium) using high-throughput sequencing technologies. This research includes developing new tools to integrate genetic and important phenotypic information on maps, and devising analytical methods to identify genetic regions (e.g. structural variants) that associate with important disease phenotypes of host and pathogens (e.g. drug resistance). Taane is a member of the LSHTM Malaria Centre and is involved in establishing a new genetic epidemiology centre. He is collaborating on school-initiated genome-wide association studies in developing countries, co-initiating global genetic diversity projects of Mtb, and provides statistical / epidemiology support and training to the Malaria Genomic Epidemiology Network and pathogen groups at the WTSI.

• Selected publications

• Allelic heterogeneity of G6PD deficiency in West Africa and severe malaria susceptibility.

  Clark, T.G.; Fry, A.E.; Auburn, S.; Campino, S.; Diakite, M.; Green, A.; Richardson, A.; Teo, Y.Y.; Small, K.; Wilson, J.; Jallow, M.; Sisay-Joof, F.; Pinder, M.; Sabeti, P.; Kwiatkowski, D.P.; Rockett, K.A.;

  Eur J Hum Genet, 2009; 17(8):1080-5

• Genome-wide and fine-resolution association analysis of malaria in West Africa

  Jallow, M.; Teo, Y.Y.; Small, K.S.; Rockett, K.A.; Deloukas, P.; Clark, T.G.; Kivinen, K.; Bojang, K.A.; Conway, D.J.; Pinder, M.; Sirugo, G.; Sisay-Joof, F.; Usen, S.; Auburn, S.; Bumpstead, S.J.; Campino, S.; Coffey, A.; Dunham, A.; Fry, A.E.; Green, A.; Gwilliam, R.; Hunt, S.E.; Inouye, M.; Jeffreys, A.E.; Mendy, A.; Palotie, A.; Potter, S.; Ragoussis, J.; Rogers, J.; Rowlands, K.; Somaskantharajah, E.; Whittaker, P.; Widden, C.; Donnelly, P.; Howie, B.; Marchini, J.; Morris, A.; Sanjoaquin, M.; Achidi, E.A.; Agbenyega, T.; Allen, A.; Amodu, O.; Corran, P.; Djimde, A.; Dolo, A.; Doumbo, O.K.; Drakeley, C.; Dunstan, S.; Evans, J.; Farrar, J.; Fernando, D.; Hien, T.T.; Horstmann, R.D.; Ibrahim, M.; Karunaweera, N.; Kokwaro, G.; Koram, K.A.; Lemnge, M.; Makani, J.; Marsh, K.; Michon, P.; Modiano, D.; Molyneux, M.E.; Mueller, I.; Parker, M.; Peshu, N.; Plowe, C.V.; Puijalon, O.; Reeder, J.; Reyburn, H.; Riley, E.M.; Sakuntabhai, A.; Singhasivanon, P.; Sirima, S.; Tall, A.; Taylor, T.E.; Thera, M.; Troye-Blomberg, M.; Williams, T.N.; Wilson, M.; Kwiatkowski, D.P.

  Nature Genetics, 2009; 41:657-665

• Genome-wide comparisons of variation in linkage disequilibrium.

  Teo, Y.Y.; Fry, A.E.; Bhattacharya, K.; Small, K.S.; Kwiatkowski, D.P.; Clark, T.G.;

  Genome Res, 2009; 19(10):1849-60

• SnoopCGH: software for visualizing comparative genomic hybridization data.

  Almagro-Garcia, J.; Manske, M.; Carret, C.; Campino, S.; Auburn, S.; Macinnis, B.L.; Maslen, G.; Pain, A.; Newbold, C.I.; Kwiatkowski, D.P.; Clark, T.G.;

  Bioinformatics, 2009; 25(20):2732-3

• The genome of the simian and human malaria parasite Plasmodium knowlesi.

  Pain, A.; B?hme, U.; Berry, A.E.; Mungall, K.; Finn, R.D.; Jackson, A.P.; Mourier, T.; Mistry, J.; Pasini, E.M.; Aslett, M.A.; Balasubrammaniam, S.; Borgwardt, K.; Brooks, K.; Carret, C.; Carver, T.J.; Cherevach, I.; Chillingworth, T.; Clark, T.G.; Galinski, M.R.; Hall, N.; Harper, D.; Harris, D.; Hauser, H.; Ivens, A.; Janssen, C.S.; Keane, T.; Larke, N.; Lapp, S.; Marti, M.; Moule, S.; Meyer, I.M.; Ormond, D.; Peters, N.; Sanders, M.; Sanders, S.; Sargeant, T.J.; Simmonds, M.; Smith, F.; Squares, R.; Thurston, S.; Tivey, A.R.; Walker, D.; White, B.; Zuiderwijk, E.; Churcher, C.; Quail, M.A.; Cowman, A.F.; Turner, C.M.; Rajandream, M.A.; Kocken, C.H.; Thomas, A.W.; Newbold, C.I.; Barrell, B.G.; Berriman, M.;

  Nature, 2008; 455(7214):799-803

• A global network for investigating the genomic epidemiology of malaria.

  Malaria Genomic Epidemiology Network: Achidi, EA; Agbenyega, T; Allen, S; Amodu, O; Bojang, K; Conway, D; Corran, P; Deloukas, P; Djimde, A; Dolo, A; Doumbo, O; Drakeley, C; Duffy, P; Dunstan, S; Evans, J; Farrar, J; Fernando, D; Tran, TH; Horstmann, R; Ibrahim, M; Karunaweera, N; Kokwaro, G; Koram, K; Kwiatkowski, D; Lemnge, M; Makani, J; Marsh, K; Michon, P; Modiano, D; Molyneux, ME; Mueller, I; Mutabingwa, T; Parker, M; Peshu, N; Plowe, C; Puijalon, O; Ragoussis, J; Reeder, J; Reyburn, H; Riley, E; Rogers, J; Sakuntabhai, A; Singhasivanon, P; Sirima, S; Sirugo, G; Tall, A; Taylor, T; Thera, M; Troye-Blomberg, M; Williams, T; Wilson, M; Amenga-Etego, L; Apinjoh, TO; Bougouma, E; Dewasurendra, R; Diakite, M; Enimil, A; Hussein, A; Ishengoma, D; Jallow, M; Lin, E; Ly, A; Mangano, VD; Manjurano, A; Manning, L; Ndila, CM; Nyirongo, V; Oluoch, T; Nguyen, TN; Suriyaphol, P; Toure, O; Rockett, KA; Vanderwal, A; Clark, T; Parker, M; Wrigley, R; Kwiatkowski, D; Alcock, D; Auburn, S; Barnwell, D; Bull, S; Campino, S; deVries, J; Elzein, A; Evans, J; Fitzpatrick, K; Ghansah, A; Green, A; Hart, L; Hilton, E; Hubbart, C; Hughes, C; Jeffreys, AE; Kivinen, K; MacInnis, B; Manske, M; Maslen, G; McCreight, M; Mendy, A; Moyes, C; Nyika, A; Potter, C; Risley, P; Rowlands, K; SanJoaquin, M; Small, K; Somaskantharajah, E; Stevens, M; Teo, Y; Watson, R; Agbenyega, T; Carucci, D; Cook, K; Doyle, A; Duombo, O; Farrar, J; Gottlieb, M; Marsh, K; Puijalon, O; Taylor, T; Kwiatkowski, D.

  Nature, 2008; 456(7223):732-7

• Functional constraint and small insertions and deletions in the ENCODE regions of the human genome.

  Clark, T.G.; Andrew, T.; Cooper, G.M.; Margulies, E.H.; Mullikin, J.C.; Balding, D.J.;

  Genome Biol, 2007; 8(9):R180

• A genotype calling algorithm for the Illumina BeadArray platform.

  Teo, Y.Y.; Inouye, M.; Small, K.S.; Gwilliam, R.; Deloukas, P.; Kwiatkowski, D.P.; Clark, T.G.;

  Bioinformatics, 2007; 23(20):2741-6

• → View all Dr Taane Clark's publications

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