Professor Graham Clark BSc PhD
- Graham Clark's Contacts
- Room 367
- Keppel Street
- WC1E 7HT
- T: 44 20 7927 2351
- F: 44 20 7636 8739
I joined the Department in 1996, after obtaining a BSc (Hons) in Zoology from the University of Edinburgh, a PhD from the Rockefeller University in New York, and postdoctoral training at the U.S. National Institutes of Health in Bethesda, Maryland. (Full CV)
- Department of Pathogen Molecular Biology
- Faculty of Infectious and Tropical Diseases
- Division of Education
I teach molecular biology methods, lecture on gut protozoa, and contribute to phylogenetics teaching as part of various modules. I was for 10 years the Programme Director for the MSc in Molecular Biology of Infectious Diseases and a member of the course and examination committees for the MSc in Medical Parasitology. From August 2009 until September 2016 I was Taught Programme Director for the Faculty of Infectious and Tropical Diseases, which meant I had oversight of teaching on all the MScs, Short Courses and modules run by the Faculty. In February 2014 I became Associate Dean of Education with responsibility for Quality, Academic Standards and Collaborative Provision across the School.
My main interests are in the genetic diversity and evolution of gut protozoan parasites, especially Entamoeba histolytica, the agent responsible for amoebic dysentery and amoebic liver abscesses, other species of Entamoeba, and Blastocystis, an organism of uncertain pathogenicity. I was involved in the E. histolytica genome project and I run the Entamoeba Homepage. The work on Blastocystis has focussed on its mitochondrial genome in an attempt to understand the function of the organelle in this anaerobic organism. Genome sequencing of Blastocystis and its relative Proteromonas - both mitochondrial and nuclear - is being undertaken at present. Genetic diversity within and between species is being explored in both Entamoeba and Blastocystis. My ORCID ID is 0000-0002-0521-0977
- Molecular biology
- Molecular epidemiology
Disease and Health Conditions
- Diarrhoeal diseases
- Emerging Infectious Disease
- Neglected Tropical Diseases (NTDs)
- United Kingdom
- Biodiversity And Health
Blastocystis mitochondrial genomes appear to show multiple independent gains and losses of start and stop codons.
Jacob, A.S.; Andersen, L.O.; Bitar, P.P.; Richards, V.P.; Shah, S.; Stanhope, M.J.; Stensvold, C.R.; Clark, C.G.;
Genome Biol Evol, 2016; 8(11):3340-3350
Expanding the Entamoeba Universe: New Hosts Yield Novel Ribosomal Lineages.
Jacob, A.S. ; Busby, E.J. ; Levy, A.D. ; Komm, N. ; Clark, C.G. ;
J Eukaryot Microbiol, 2015; 63(1):69-78
Variable geographic distribution of Blastocystis subtypes and its potential implications.
Alfellani, M.A.; Stensvold, C.R.; Vidal-Lapiedra, A.; Onuoha, E.S.; Fagbenro-Beyioku, A.F.; Clark, C.G.;
Acta Trop, 2013; 126:11-18
Genetic Diversity of Blastocystis in Livestock and Zoo Animals.
Alfellani, M.A. ; Taner-Mulla, D. ; Jacob, A.S. ; Imeede, C.A. ; Yoshikawa, H. ; Stensvold, C.R. ; Clark, C.G. ;
Protist, 2013; 164(4):497-509
Increased Sampling Reveals Novel Lineages of Entamoeba: Consequences of Genetic Diversity and Host Specificity for Taxonomy and Molecular Detection
Stensvold, C.R.; Lebbad, M.; Victory, E.L.; Verweij, J.J.; Tannich, E.; Alfellani, M.; Legarraga, P.; Clark, C.G.
Protist, 2011; 162(3):525-541
Patterns of Evolution in the Unique tRNA Gene Arrays of the Genus Entamoeba.
Tawari, B.; Ali, I.K.; Scott, C.; Quail, M.A.; Berriman, M.; Hall, N.; Clark, C.G.;
Mol Biol Evol, 2008; 25(1):187-198
Organelles in Blastocystis that Blur the Distinction between Mitochondria and Hydrogenosomes.
Stechmann, A.; Hamblin, K.; Perez-Brocal, V.; Gaston, D.; Richmond, G.S.; van der Giezen, M.; Clark, C.G.; Roger, A.J.;
Curr Biol, 2008; 18(8):580-5
Analysis of two genomes from the mitochondrion-like organelle of the intestinal parasite Blastocystis: Complete sequences, gene content and genome organization.
Pérez-Brocal, V.; Clark, C.G.;
Mol Biol Evol, 2008; 25(11):2475-82
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