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Prof Graham Clark

Professor of Molecular Parasitology

United Kingdom

Tel.
02079272351

I joined the Department in 1996, after obtaining a BSc (Hons) in Zoology from the University of Edinburgh, a PhD from the Rockefeller University in New York, and postdoctoral training at the U.S. National Institutes of Health in Bethesda, Maryland. Following 10 years as a Programme Director, from August 2009 until September 2016 I was Taught Programme Director for the Faculty of Infectious and Tropical Diseases, which meant I had oversight of teaching on all the MScs, Short Courses and modules run by the Faculty. In February 2014 I became Associate Dean of Education with responsibility for Quality, Academic Standards and Collaborative Provision across the School, and I am a member of several School-level education committees..

Affiliations

Department of Infection Biology
Faculty of Infectious and Tropical Diseases

Teaching

I teach molecular biology methods and lecture on gut protozoa as part of various modules.

Research

My main interests are in the genetic diversity and evolution of gut protozoan parasites, especially Entamoeba histolytica, the agent responsible for amoebic dysentery and amoebic liver abscesses, other species of Entamoeba, and Blastocystis, an organism of uncertain pathogenicity. I was involved in the E. histolytica genome project and I run the Entamoeba Homepage. The work on Blastocystis has focussed on its mitochondrial genome in an attempt to understand the function of the organelle in this anaerobic organism. Genome sequencing of Blastocystis and its relative Proteromonas - both mitochondrial and nuclear - is being undertaken at present. Genetic diversity within and between species is being explored in both Entamoeba and Blastocystis as well as other gut protozoa.

Research Area
Parasites
Protozoa
Genomics
Molecular biology
Molecular epidemiology
Parasitology
Disease and Health Conditions
Diarrhoeal diseases
Region
World

Selected Publications

Evolutionary analysis of cellular reduction and anaerobicity in the hyper-prevalent gut microbe Blastocystis.
Záhonová, K; Low, RS; Warren, CJ; Cantoni, D; Herman, EK; Yiangou, L; Ribeiro, CA; Phanprasert, Y; Brown, IR; Rueckert, S; Baker, NL; Tachezy, J; Betts, EL; Gentekaki, E; Van der Giezen, M; CLARK, CG; Jackson, AP; Dacks, JB; Tsaousis, AD;
2023
Current Biology
Pre-empting Pandora's Box: Blastocystis Subtypes Revisited.
Stensvold, CR; CLARK, CG;
2020
Trends in Parasitology
Differentiation of Blastocystis and parasitic archamoebids encountered in untreated wastewater samples by amplicon-based next-generation sequencing.
Stensvold, CR; Lebbad, M; Hansen, A; Beser, J; Belkessa, S; O'Brien Andersen, L; CLARK, CG;
2019
Parasite Epidemiology and Control
Genetic Diversity and Gene Family Expansions in Members of the Genus Entamoeba.
Wilson, IW; Weedall, GD; Lorenzi, H; Howcroft, T; Hon, C-C; Deloger, M; Guillén, N; Paterson, S; CLARK, CG; Hall, N;
2019
Genome Biology and Evolution
Extreme genome diversity in the hyper-prevalent parasitic eukaryote Blastocystis.
Gentekaki, E; Curtis, BA; Stairs, CW; Klimeš, V; Eliáš, M; Salas-Leiva, DE; Herman, EK; Eme, L; Arias, MC; Henrissat, B; Hilliou, F; Klute, MJ; Suga, H; Malik, S-B; Pightling, AW; Kolisko, M; Rachubinski, RA; Schlacht, A; Soanes, DM; Tsaousis, AD; Archibald, JM; Ball, SG; Dacks, JB; CLARK, CG; Van der Giezen, M; ... Roger, AJ.
2017
PLoS biology
Blastocystis Mitochondrial Genomes Appear to Show Multiple Independent Gains and Losses of Start and Stop Codons.
JACOB, AS; Andersen, LO; Bitar, PP; Richards, VP; Shah, S; Stanhope, MJ; Stensvold, CR; CLARK, CG;
2016
Genome biology and evolution
Genetic diversity of blastocystis in livestock and zoo animals.
Alfellani, MA; Taner-Mulla, D; JACOB, AS; Imeede, CA; Yoshikawa, H; Stensvold, CR; CLARK, CG;
2013
Protist
Variable geographic distribution of Blastocystis subtypes and its potential implications.
Alfellani, MA; Stensvold, CR; Vidal-Lapiedra, A; Onuoha, ES U; Fagbenro-Beyioku, AF; CLARK, CG;
2013
Acta tropica
Evolutionary analysis of cellular reduction and anaerobicity in the hyper-prevalent gut microbe Blastocystis
Záhonová, K; Low, RS; Warren, CJ; Cantoni, D; Herman, EK; Yiangou, L; Ribeiro, CA; Phanprasert, Y; Brown, IR; Rueckert, S; Baker, NL; Tachezy, J; Betts, EL; Gentekaki, E; Van der Giezen, M; CLARK, CG; Jackson, AP; Dacks, JB; Tsaousis, AD;
2023
Current Biology
Further insight into the genetic diversity of Entamoeba coli and Entamoeba hartmanni.
Stensvold, CR; Ascuña-Durand, K; Chihi, A; Belkessa, S; Kurt, Ö; El-Badry, A; Van der Giezen, M; CLARK, CG;
2022
Journal of eukaryotic microbiology
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