Dr Antoine Claessens PhD
- Antoine Claessens's Contacts
- Keppel Street
- WC1E 7HT
- T: +220 44 95 443, ext 3016
I am a Research Fellow on a joint LSHTM/MRC-Gambia fellowship from the MRC. After my PhD at Edinburgh University with Pr Alex Rowe and a post-doc with Pr Dominic Kwiatkowski at the Sanger Institute, I joined LSHTM in 2014. I'm mainly based at the MRC-Gambia in Fajara, The Gambia, West Africa.
My current research focuses on genomics of Plasmodium falciparum asymptomatic infection.
The Plasmodium falciparum population in The Gambia fluctuates between a high prevalence in the wet season (transmission season) to a low prevalence in the dry season (no transmission). This drastic environmental change likely selects parasites that are genetically better suited for one environment or the other. We regularly collect blood samples from asymptomatic volunteers, sequence P. falciparum genomes and compare allele frequency variations between pre and post-transmission seasons. I am testing the hypothesis that some parasite allele frequencies will be associated with survival over the dry season.
Scientific interest keywords: Malaria, genomics, transcriptomics, antigenic variation, var genes, mutation rate, G-quadruplex.
- Genetic epidemiology
- Molecular biology
Disease and Health Conditions
- Gambia, The
- Antigenic Variation
- mutation rate
- var genes
Generation of antigenic diversity in Plasmodium falciparum by structured rearrangement of Var genes during mitosis.
Claessens, A. ; Hamilton, W.L. ; Kekre, M. ; Otto, T.D. ; Faizullabhoy, A. ; Rayner, J.C. ; Kwiatkowski, D. ;
PLoS Genet, 2014; 10(12):e1004812
Selection of Plasmodium falciparum parasites for cytoadhesion to human brain endothelial cells.
Claessens, A. ; Rowe, J.A. ;
J Vis Exp, 2012; (59):e3122
A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells.
Claessens, A. ; Adams, Y. ; Ghumra, A. ; Lindergard, G. ; Buchan, C.C. ; Andisi, C. ; Bull, P.C. ; Mok, S. ; Gupta, A.P. ; Wang, C.W. ; Turner, L. ; Arman, M. ; Raza, A. ; Bozdech, Z. ; Rowe, J.A. ;
Proc Natl Acad Sci U S A, 2012; 109(26):E1772-81
Design of a variant surface antigen-supplemented microarray chip for whole transcriptome analysis of multiple Plasmodium falciparum cytoadherent strains, and identification of strain-transcendent rif and stevor genes.
Claessens, A. ; Ghumra, A. ; Gupta, A.P. ; Mok, S. ; Bozdech, Z. ; Rowe, J.A. ;
Malar J, 2011; 10:180
Adhesion of Plasmodium falciparum-infected erythrocytes to human cells: molecular mechanisms and therapeutic implications.
Rowe, J.A. ; Claessens, A. ; Corrigan, R.A. ; Arman, M. ;
Expert Rev Mol Med, 2009; 11:e16
Putative DNA G-quadruplex formation within the promoters of Plasmodium falciparum var genes.
Smargiasso, N. ; Gabelica, V. ; Damblon, C. ; Rosu, F. ; De Pauw, E. ; Teulade-Fichou, M.P. ; Rowe, J.A. ; Claessens, A. ;
BMC Genomics, 2009; 10:362
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