Sarah Burr BSc MSc PhD

Lecturer

• Affiliation
• Research
• Publications

• 
• Medical Research Council Unit, The Gambia
• LSHTM
• Keppel Street
• London
• WC1E 7HT
• T: 220 449 5010

I graduated from the University of British Columbia with a BSc in Microbiology in 1996. After two years working in a diagnostic microbiology lab, I enrolled in the University of Victoria where I studied type II protein secretion in gram negative bacteria. After finishing my MSc in 2001, I relocated to Switzerland where I began work on a PhD at the Institute of Veterinary Bacteriology, Universitaet Bern. My PhD project involved the characterization of the type III secretion system in Aeromonas salmonicida. I completed my thesis in 2004 and remained at the Institute of Veterinary Bacteriology as a post-doctoral fellow studying virulence factors of Aeromonas species until 2009 when I joined Professor Mabey's group at the LSHTM.

Affiliation

• Department of Clinical Research

Research

I am based at the Medical Research Council Unit, The Gambia where I co-ordinate trachoma research activities on behalf of the LHSTM. I am currently involved in the Partnership for the Rapid Elimination of Trachoma (PRET) trial, where we are comparing different treatment strategies to determine the most cost-effective use of mass azithromycin treatment. This is a Gates-funded project in collaboration with Johns Hopkins University and UCSF. I am also involved in an ancillary study into the impact of azithromycin on nasopharyngeal carriage of Streptococcus pneumoniae and other respiratory pathogens.

• Selected publications

• Pseudomonas chlororaphis subsp. piscium subsp. nov., isolated from fresh-water fish.

  Burr, S.E.; Gobeli, S.; Kuhnert, P.; Goldschmidt-Clermont, E.; Frey, J.;

  Int J Syst Evol Microbiol, 2010;

• Trachoma Prevalence and Associated Risk Factors in The Gambia and Tanzania: Baseline Results of a Cluster Randomised Controlled Trial.

  Harding-Esch, E.M.; Edwards, T.; Mkocha, H.; Munoz, B.; Holland, M.J.; Burr, S.E.; Sillah, A.; Gaydos, C.A.; Stare, D.; Mabey, D.C.; Bailey, R.L.; West, S.K.; for the PRET Partnership, .;

  PLoS Negl Trop Dis, 2010; 4(11):e861

• The AsaP1 peptidase of Aeromonas salmonicida subsp. achromogenes is a highly conserved deuterolysin metalloprotease (family M35) and a major virulence factor.

  Arnadottir, H.; Hvanndal, I.; Andresdottir, V.; Burr, S.E.; Frey, J.; Gudmundsdottir, B.K.;

  J Bacteriol, 2009; 191(1):403-10

• Aeromonas exoenzyme T of Aeromonas salmonicida is a bifunctional protein that targets the host cytoskeleton.

  Fehr, D.; Burr, S.E.; Gibert, M.; d'Alayer, J.; Frey, J.; Popoff, M.R.;

  J Biol Chem, 2007; 282(39):28843-52

• AopP, a type III effector protein of Aeromonas salmonicida, inhibits the NF-kappaB signalling pathway.

  Fehr, D.; Casanova, C.; Liverman, A.; Blazkova, H.; Orth, K.; Dobbelaere, D.; Frey, J.; Burr, S.E.;

  Microbiology, 2006; 152(Pt 9):2809-18

• Attenuated virulence of an Aeromonas salmonicida subsp. salmonicida type III secretion mutant in a rainbow trout model.

  Burr, S.E.; Pugovkin, D.; Wahli, T.; Segner, H.; Frey, J.;

  Microbiology, 2005; 151(Pt 6):2111-8

• The ADP-ribosylating toxin, AexT, from Aeromonas salmonicida subsp. salmonicida is translocated via a type III secretion pathway.

  Burr, S.E.; Stuber, K.; Frey, J.;

  J Bacteriol, 2003; 185(22):6583-91

• Evidence for a type III secretion system in Aeromonas salmonicida subsp. salmonicida.

  Burr, S.E.; Stuber, K.; Wahli, T.; Frey, J.;

  J Bacteriol, 2002; 184(21):5966-70

• → View all Sarah Burr's publications

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