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Dr Christian Bottomley

Associate Professor

United Kingdom

I obtained a PhD in mathematical biology from University College London (UCL) in 2006. Since then I have worked as a medical statistician in the Department of Primary Care and Population Sciences at UCL, before joining the International Statistics and Epidemiology Group in June 2008.

Affiliations

Department of Infectious Disease Epidemiology and International Health
Faculty of Epidemiology and Population Health

Centres

Centre for Data and Statistical Science for Health
Centre for Evaluation
TB Centre
Antimicrobial Resistance Centre

Teaching

I am a course organizer for the module Design and Analysis of Epidemiological Studies, and also a tutor on the Epidemiology MSc and Clinical Trials MSc.

Research

My research interests are in applied statistics and infectious disease epidemiology.

I collaborate with investigators in The Gambia and Kenya on studies to evaluate the introduction of pneumococcal conjugate vaccines into the routine childhood vaccination schedule. Through these collaborations I have become interested in evaluating vaccines and other interventions using interrupted time series analyses.

I am also the principle statistician for several ongoing trials, including a cluster-randomsied trial of a hospital management intervention in Malawi, a trial of fractional dose pneumococcal vaccine in Kenya, and a trial of intra-partum azithromycin in The Gambia and Burkina Faso.

Selected Publications

Effect of Intrapartum Azithromycin vs Placebo on Neonatal Sepsis and Death: A Randomized Clinical Trial.
ROCA, A; CAMARA, B; Bognini, JD; Nakakana, UN; Somé, AM; Beloum, N; Rouamba, T; Sillah, F; Danso, M; Jones, JC; Graves, S; Jagne, I; Getanda, P; DARBOE, S; Tahita, MC; Ndure, E; Franck, HS; Edmond, SY; Dondeh, BL; Nassa, WG J; Garba, Z; Bojang, A; Njie, Y; BOTTOMLEY, C; Tinto, H; ... PregnAnZI-2 Working Group,
2023
JAMA
Quantifying previous SARS-CoV-2 infection through mixture modelling of antibody levels.
BOTTOMLEY, C; OTIENDE, M; Uyoga, S; GALLAGHER, K; Kagucia, EW; Etyang, AO; Mugo, D; Gitonga, J; Karanja, H; Nyagwange, J; ADETIFA, IM O; AGWEYU, A; Nokes, DJ; Warimwe, GM; SCOTT, JA G;
2021
Nature communications
Analysing Interrupted Time Series with a Control
BOTTOMLEY, C; SCOTT, JA G; Isham, V;
2019
Epidemiologic Methods
Effect of 10-valent pneumococcal conjugate vaccine on the incidence of radiologically-confirmed pneumonia and clinically-defined pneumonia in Kenyan children: an interrupted time-series analysis.
Silaba, M; OOKO, M; BOTTOMLEY, C; Sande, J; Benamore, R; Park, K; Ignas, J; Maitland, K; Mturi, N; Makumi, A; OTIENDE, M; Kagwanja, S; Safari, S; Ochola, V; Bwanaali, T; Bauni, E; Gleeson, F; Deloria Knoll, M; ADETIFA, I; Marsh, K; Williams, TN; Kamau, T; Sharif, S; Levine, OS; Hammitt, LL; ... SCOTT, JA G.
2019
The Lancet Global Health
Comparative efficacy of low-dose versus standard-dose azithromycin for patients with yaws: a randomised non-inferiority trial in Ghana and Papua New Guinea.
MARKS, M; Mitjà, O; BOTTOMLEY, C; Kwakye, C; Houinei, W; Bauri, M; Adwere, P; Abdulai, AA; Dua, F; Boateng, L; Wangi, J; Ohene, S-A; Wangnapi, R; Simpson, SV; Miag, H; Addo, KK; Basing, LA; Danavall, D; Chi, KH; Pillay, A; Ballard, R; Solomon, AW; Chen, CY; Bieb, SV; Adu-Sarkodie, Y; ... Study team,
2018
The Lancet Global health
Housing Improvements and Malaria Risk in Sub-Saharan Africa: A Multi-Country Analysis of Survey Data.
TUSTING, LS; BOTTOMLEY, C; Gibson, H; KLEINSCHMIDT, I; Tatem, AJ; Lindsay, SW; Gething, PW;
2017
PLoS medicine
Modelling Neglected Tropical Diseases diagnostics: the sensitivity of skin snips for Onchocerca volvulus in near elimination and surveillance settings.
BOTTOMLEY, C; Isham, V; Vivas-Martínez, S; Kuesel, AC; Attah, SK; Opoku, NO; Lustigman, S; Walker, M; Basáñez, M-G;
2016
Parasites & vectors
Oral azithromycin given during labour decreases bacterial carriage in the mothers and their offspring: a double-blind randomized trial.
ROCA, A; Oluwalana, C; Bojang, A; CAMARA, B; KAMPMANN, B; BAILEY, R; Demba, A; BOTTOMLEY, C; D'ALESSANDRO, U;
2016
Clinical microbiology and infection
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