Christian Bottomley PhD
- Christian Bottomley's Contacts
- Keppel Street
- WC1E 7HT
- T: 020 7927 2533
I obtained a PhD in mathematical biology from University College London (UCL) in 2006. Since then I have worked as a medical statistician in the Department of Primary Care and Population Sciences at UCL, before joining the Tropical Epidemiology Group in June 2008.
- Centre for Evaluation
- Mathematical Modelling of Infectious Diseases
- Statistical Methodology
- Vaccine Centre
I am a course organizer for Design and Analysis of Epidemiological Studies (DANES) and teach on the courses Statistics for Epidemiology and Public Health (STEPH), and Advanced Statistical Methods in Epidemiology (ASME).
My research interests are in statistics, mathematical modelling and epidemiology.
I collaborate with investigators in The Gambia and Kenya on studies to evaluate the introduction of pneumococcal conjugate vaccines into the routine childhood vaccination schedule.
Currently I am also the principle statistician for a trial in which antibiotics are being given to women in labour with the aim of reducing bacterial transmission to infants (PregnAnZI).
- Clinical trials
- Complex interventions
- Statistical methods
- Mathematical modelling
Disease and Health Conditions
- Infectious disease
Can the buck always be passed to the highest level of clustering?
Bottomley, C. ; Kirby, M.J. ; Lindsay, S.W. ; Alexander, N. ;
BMC Med Res Methodol, 2016; 16(1):29
Modelling Neglected Tropical Diseases diagnostics: the sensitivity of skin snips for Onchocerca volvulus in near elimination and surveillance settings.
Bottomley, C. ; Isham, V. ; Vivas-Martínez, S. ; Kuesel, A.C. ; Attah, S.K. ; Opoku, N.O. ; Lustigman, S. ; Walker, M. ; Basáñez, M.G. ;
Parasit Vectors, 2016; 9(1):343
Cryptococcal meningitis screening and community-based early adherence support in people with advanced HIV infection starting antiretroviral therapy in Tanzania and Zambia: an open-label, randomised controlled trial.
Mfinanga, S.; Chanda, D.; Kivuyo, S.L.; Guinness, L.; Bottomley, C.; Simms, V.; Chijoka, C.; Masasi, A.; Kimaro, G.; Ngowi, B.; Kahwa, A.; Mwaba, P.; Harrison, T.S.; Egwaga, S.; Jaffar, S.; REMSTART trial team, .;
Lancet, 2015; 385(9983):2173-82
Prevalence of active convulsive epilepsy in sub-Saharan Africa and associated risk factors: cross-sectional and case-control studies.
Ngugi, A.K.; Bottomley, C.; Kleinschmidt, I.; Wagner, R.G.; Kakooza-Mwesige, A.; Ae-Ngibise, K.; Owusu-Agyei, S.; Masanja, H.; Kamuyu, G.; Odhiambo, R.; Chengo, E.; Sander, J.W.; Newton, C.R.; SEEDS group, .;
Lancet Neurol, 2013; 12(3):253-63
A mathematical model of serotype replacement in pneumococcal carriage following vaccination.
Bottomley, C. ; Roca, A. ; Hill, P.C. ; Greenwood, B. ; Isham, V. ;
J R Soc Interface, 2013; 10(89):20130786
Effect of two different house screening interventions on exposure to malaria vectors and on anaemia in children in The Gambia: a randomised controlled trial
Kirby, M.J.; Ameh, D.; Bottomley, C.; Green, C.; Jawara, M.; Milligan, P.J.; Snell, P.C.; Conway, D.J.; Lindsay, S.W.
Lancet, 2009; 374(9694):998-1009
Rates of microfilarial production by Onchocerca volvulus are not cumulatively reduced by multiple ivermectin treatments.
Bottomley, C.; Isham, V.; Collins, R.C.; Bas??ez, M.G.;
Parasitology, 2008; 135(13):1571-81
Population biology of multispecies helminth infection: competition and coexistence.
Bottomley, C.; Isham, V.; Basáñez, MG.
J Theor Biol, 2007; 244(1):81-95
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