Professor Quentin Bickle BA MSc PhD
- Quentin Bickle's Contacts
- Room 484
- Keppel Street
- WC1E 7HT
- T: 44 20 7927 2609
- F: 44 20 7323 5687
After a degree in Zoology, I took the MSc in Medical Parasitology at LSHTM. My PhD project, on mechanisms of vaccine-induced immunity against schistosomes, was carried out at the LSHTM field station, Winches farm, during which time I also worked at the National Institute for Medical Research on schistosome antigens/antigen genes. After a year’s sabbatical at the Walter and Eliza Hall Institute in Melbourne working on malaria antigen genes I returned to work at the Keppel Street site of LSHTM, continuing studies on the immunology of helminths and of coinfections between helminths and protozoa or viruses. I have also been involved in field research on the immunology and control of intestinal worm infections.
The focus of my current research is on discovery of new anthelmintic drugs. This is based on novel techniques we developed at LSHTM e.g. use of an automated, whole-organism, High-throughput drug screen (HTS) using High Content imaging. This has allowed HT screening of very large compound collections provided by pharma and academia. Through collaboration with medicinal chemists the aim is to develop the lead compounds we have discovered into new clinical candidates for schistosomiasis and to extend use of the technology for screening against other helminth species.
- Drug discovery and development
- Molecular biology
Disease and Health Conditions
- Latin America & Caribbean (all income levels)
- Sub-Saharan Africa (all income levels)
- Intestinal Nematodes
High Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoni.
Mansour, N.R. ; Paveley, R. ; Gardner, J.M. ; Bell, A.S. ; Parkinson, T. ; Bickle, Q. ;
PLoS Negl Trop Dis, 2016; 10(4):e0004659
Application of RNAi to Genomic Drug Target Validation in Schistosomes.
Guidi, A. ; Mansour, N.R. ; Paveley, R.A. ; Carruthers, I.M. ; Besnard, J. ; Hopkins, A.L. ; Gilbert, I.H. ; Bickle, Q.D. ;
PLoS Negl Trop Dis, 2015; 9(5):e0003801
Whole organism high-content screening by label-free, image-based bayesian classification for parasitic diseases.
Paveley, R.A. ; Mansour, N.R. ; Hallyburton, I. ; Bleicher, L.S. ; Benn, A.E. ; Mikic, I. ; Guidi, A. ; Gilbert, I.H. ; Hopkins, A.L. ; Bickle, Q.D. ;
PLoS Negl Trop Dis, 2012; 6(7):e1762
Early Exposure of Infants to GI Nematodes Induces Th2 Dominant Immune Responses Which Are Unaffected by Periodic Anthelminthic Treatment.
Wright, V.J.; Ame, S.M.; Haji, H.S.; Weir, R.E.; Goodman, D.; Pritchard, D.I.; Mohamed, M.R.; Haji, H.J.; Tielsch, J.M.; Stoltzfus, R.J.; Bickle, Q.D.;
PLoS Negl Trop Dis, 2009; 3(5):e433
Schistosomes: challenges in compound screening
Ramirez, B.; Bickle, Q.; Yousif, F.; Fakorede, F.K.; Mouries, M-A.; Nwaka, S.
Expert Opinion on Drug Discovery, 2007; 2(1):S53-S61
The Schistosoma mansoni Hepatic Egg Granuloma Provides a Favorable Microenvironment for Sustained Growth of Leishmania donovani.
Hassan, M.F.; Zhang, Y.; Engwerda, C.R.; Kaye, P.M.; Sharp, H.; Bickle, Q.D.;
Am J Pathol, 2006; 169(3):943-53
Reciprocal immunomodulation in a schistosome and hepatotropic virus coinfection model
Edwards, M. J.; Buchatska, E.; Ashton, M.; Montoya, M.; Bickle, Q. D.; Borrow, P.
Journal of Immunology, 2005; 175(10):6275-85
Laboratory and field evaluation of Schistosoma japonicum DNA vaccines in sheep and water buffalo in China
Shi, F. H.; Zhang, Y. B.; Ye, P.; Lin, J. J.; Cai, Y. M.; Shen, W.; Bickle, Q. D.; Taylor, M. G.
Vaccine, 2001; 20(3-4):462-467
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