Quentin Bickle BA MSc PhD
- Quentin Bickle's Contacts
- Room 484
- Keppel Street
- WC1E 7HT
- T: 44 20 7927 2609
- F: 44 20 7323 5687
After graduating with a degree in Zoology an interest in insects led to the MSc in Medical Parasitology at LSHTM. Learning about the parasites themselves resulted in a particular focus on schistosomes. Encouraged by Professor George Nelson (the Head of the Helminthology Department at the time) he joined Martin Taylor at Winches farm, the field station of LSHTM in St Albans, to work on mechanisms of irradiated vaccine-induced immunity against schistosomes, completing a London University PhD, further postdoctoral studies and an MSc in Applied Immunology at Brunel University. During subsequent employment at the field station he spent time at the National Insitute for Medical Research in London working on schistosome molecular biology and took a year sabbatical at the Walter and Eliza Hall Institute in Melbourne working on malaria antigen genes. On his return he moved to the Keppel Street site of LSHTM.
Current major focus is on drug discovery for new anthelmintic drugs based on novel techniques developed at LSHTM, notably an automated, whole-organism, High-throughput screen (HTS) using High Content imaging for activity against schistosomes. This allows HT screening of very large compound collections provided by pharma and academia. Through collaboration with medicinal chemists the aim is to develop new clinical candidates for schistosomiasis and to extend use of the technology for screening against other helminth species.
- Drug discovery and development
- Molecular biology
Disease and Health Conditions
- Latin America & Caribbean (all income levels)
- Sub-Saharan Africa (all income levels)
- Intestinal Nematodes
Application of RNAi to Genomic Drug Target Validation in Schistosomes.
Guidi, A. ; Mansour, N.R. ; Paveley, R.A. ; Carruthers, I.M. ; Besnard, J. ; Hopkins, A.L. ; Gilbert, I.H. ; Bickle, Q.D. ;
PLoS Negl Trop Dis, 2015; 9(5):e0003801
Whole organism high-content screening by label-free, image-based bayesian classification for parasitic diseases.
Paveley, R.A. ; Mansour, N.R. ; Hallyburton, I. ; Bleicher, L.S. ; Benn, A.E. ; Mikic, I. ; Guidi, A. ; Gilbert, I.H. ; Hopkins, A.L. ; Bickle, Q.D. ;
PLoS Negl Trop Dis, 2012; 6(7):e1762
Comparison of microscopy and alamar blue reduction in a larval based assay for schistosome drug screening.
Mansour, N.R.; Bickle, Q.D.;
PLoS Negl Trop Dis, 2010; 4(8):e795
Early Exposure of Infants to GI Nematodes Induces Th2 Dominant Immune Responses Which Are Unaffected by Periodic Anthelminthic Treatment.
Wright, V.J.; Ame, S.M.; Haji, H.S.; Weir, R.E.; Goodman, D.; Pritchard, D.I.; Mohamed, M.R.; Haji, H.J.; Tielsch, J.M.; Stoltzfus, R.J.; Bickle, Q.D.;
PLoS Negl Trop Dis, 2009; 3(5):e433
Schistosomes: challenges in compound screening
Ramirez, B.; Bickle, Q.; Yousif, F.; Fakorede, F.K.; Mouries, M-A.; Nwaka, S.
Expert Opinion on Drug Discovery, 2007; 2(1):S53-S61
The Schistosoma mansoni Hepatic Egg Granuloma Provides a Favorable Microenvironment for Sustained Growth of Leishmania donovani.
Hassan, M.F.; Zhang, Y.; Engwerda, C.R.; Kaye, P.M.; Sharp, H.; Bickle, Q.D.;
Am J Pathol, 2006; 169(3):943-53
Reciprocal immunomodulation in a schistosome and hepatotropic virus coinfection model
Edwards, M. J.; Buchatska, E.; Ashton, M.; Montoya, M.; Bickle, Q. D.; Borrow, P.
Journal of Immunology, 2005; 175(10):6275-85
Laboratory and field evaluation of Schistosoma japonicum DNA vaccines in sheep and water buffalo in China
Shi, F. H.; Zhang, Y. B.; Ye, P.; Lin, J. J.; Cai, Y. M.; Shen, W.; Bickle, Q. D.; Taylor, M. G.
Vaccine, 2001; 20(3-4):462-467
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