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Professor Gregory Bancroft

BSc PhD

Professor
of Immunology

Greg graduated from the University of Western Australia with a BScHons from the laboratory of Prof. Geoffrey Shellam, having completed a research project on the role of NK cells in genetically determined resistance against murine cytomegalovirus.  He completed a PhD at the National Institute for Medical Research Mill Hill, London under the guidance of Dr Ita Askonas on the role of macrophages in immunity to African trypanosomiasis, which started his interests in phagocyte biology and pathways of macrophage activation.  After a four year period studying this topic as a postdoctoral fellow at Harvard Medical School, Boston and Washington University, St Louis with Prof. Emil Unanue, Greg moved to the LSHTM in 1988, initially to study macrophage mediated immunity against the AIDS-related fungal pathogen Cryptococcus neoformans.

Affiliations

Faculty of Infectious and Tropical Diseases
Immunology and Infection Department

Centres

Tuberculosis (TB) Centre
Vaccine Centre

Teaching

Greg is the Programme Director for the Immunology of Infectious Diseases MSc, a one year course which trains future immunologists for a career in immunology research or infectious disease.

 

Research

Greg Bancroft is currently Professor of Immunology at the London School of Hygiene & Tropical Medicine.  He has over 30 years of experience working in the field of infection and immunity.  Greg’s current research relates to understanding the mechanisms of pathogenesis and the development of novel vaccines against two important pathogenic bacteria, M. tuberculosis and B. pseudomallei.  His work in tuberculosis relates to the pre-clinical evaluation for candidate live attenuated TB vaccines through the EU. This is a critical go-no go decision step in the development of the many live attenuated TB vaccines being developed within the EU framework.

He uses similar approaches of experimental modeling, cell mediated immunity and imaging in studies on the causative agent of melioidosis (B. pseudomallei), an important cause of septic death in rural Thailand and Northern Australia.  This work is done primarily with a long standing collaboration with colleagues at Khon Kaen University in the endemic region of Thailand who study human immune responses to this organism and at both Mahidol and Chulalongkorn Universities on melioidosis and tuberculosis.  Much of his work investigating the genetic basis of virulence of B. pseudomallei is in collaboration with Prof. Rick Titball (University of Exeter) and Prof. Brendan Wren (LSHTM).  He is  an Honorary Lecturer at  Mahidol University in Bangkok and Visiting Scholar at Khon Kaen University, Thailand.  In addition he has had long standing collaborations with colleagues in DSTL and at NIMR Mill Hill/Crick, the latter on tuberculosis and now more recently melioidosis research.

 

Research Area
Vaccines
Discipline
Immunology
Disease and Health Conditions
Tuberculosis
Melioidosis
Neglected Tropical Diseases (NTDs)
Country
United Kingdom
Thailand
Region
Europe & Central Asia (all income levels)

Selected Publications

Rapid in vivo assessment of drug efficacy against Mycobacterium tuberculosis using an improved firefly luciferase.
Andreu, N.; Zelmer, A.; Sampson, S.L.; Ikeh, M.; Bancroft, G.J.; Schaible, U.E.; Wiles, S.; Robertson, B.D.;
J Antimicrob Chemother
Low-Dose Exposure of C57BL/6 Mice to Burkholderia pseudomallei Mimics Chronic Human Melioidosis.
Conejero, L. ; Patel, N. ; de Reynal, M. ; Oberdorf, S. ; Prior, J. ; Felgner, P.L. ; Titball, R.W. ; Salguero, F.J. ; Bancroft, G.J. ;
Am J Pathol
Combining Vaccination and Postexposure CpG Therapy Provides Optimal Protection Against Lethal Sepsis in a Biodefense Model of Human Melioidosis
Easton, A.; Haque, A.; Chu, K.R.; Patel, N.; Lukaszewski, R.A.; Krieg, A.M.; Titball, R.W.; Bancroft, G.J.
Journal of Infectious Diseases
Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis
Pankla, R.; Buddhisa, S.; Berry, M.; Blankenship, D.M.; Bancroft, G.J.; Banchereau, J.; Lertmemongkolchai, G.; Chaussabel, D.
Genome Biology
A critical role for neutrophils in resistance to experimental infection with Burkholderia pseudomallei
Easton, A.; Haque, A.; Chu, K.; Lukaszewski, R.; Bancroft, G.J.
Journal of Infectious Diseases
A live experimental vaccine against Burkholderia pseudomallei elicits CD4(+) T cell-mediated immunity, priming T cells specific for 2 type III secretion system proteins
Haque, A.; Chu, K.; Easton, A.; Stevens, M.P.; Galyov, E.E.; Atkins, T.; Titball, R.; Bancroft, G.J.
Journal of Infectious Diseases
Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guerin mutants that secrete listeriolysin.
Grode, L.; Seiler, P.; Baumann, S.; Hess, J.; Brinkmann, V.; Eddine, A.N.; Mann, P.; Goosmann, C.; Bandermann, S.; Smith, D.; Bancroft, G.J.; Reyrat, J.M.; van Soolingen, D.; Raupach, B.; Kaufmann, S.H.;
J Clin Invest
See all Professor Gregory Bancroft's Publications