Professor David Baker BSc PhD

Professor of Malaria Parasite Biology

About David Baker

Malaria Centre Head of Biology

Background

David completed his PhD in 1988 at the University of Hull on the molecular biology of the intestinal parasite Giardia lamblia. He then moved to the London School of Hygiene & Tropical Medicine to work on the sexual stages of the malaria parasite Plasmodium falciparum. Current research is focused on investigating signal transduction pathways that regulate development of the most serious human malaria parasite Plasmodium falciparum. David is also involved in drug discovery work to exploit knowledge generated on these pathways to develop new antimalarial drugs.

Affiliation

Centres

Teaching

I am involved in various aspects of teaching the MSc in Molecular Biology of Infectious Diseases (MBID). I organise the D2 Module - Molecular Biology: Research Progress and Applications (3160).

 

Research

David Baker’s research group uses biochemical and genetic approaches to study the cyclic nucleotide signal transduction pathways of malaria parasites. The cyclic nucleotides cAMP and cGMP perform a whole spectrum of cellular functions in diverse organisms. Earlier work from other laboratories suggested that both of these second messenger molecules may play roles in malaria parasite differentiation. David's studies have focused on the cyclase enzymes that synthesise cyclic nucleotides, the phosphodiesterases that degrade them, but also on the protein kinase that is activated by cGMP (PKG). David's group have found that in Plasmodium falciparum cGMP and PKG play an essential role in triggering the formation of mature sexual parasite forms (gametogenesis) which are required to transmit disease to the mosquito vector. As part of a collaboration they also showed that this pathway is important for the development of the ookinete form of P. berghei within the mosquito. It is now becoming clear that cGMP signalling and the PKG enzyme are vital for multiple parasite stages, because using specific PKG inhibitors in conjunction with inhibitor-insensitive transgenic parasites the team have demonstrated that asexual blood stage schizogony cannot progress if this kinase is blocked. With others they have shown that PKG functions upstream of a protease cascade and a calcium-dependent protein kinase (CDPK5) that are also required for asexual blood stage schizont rupture and merozoite egress. More recently, through another collaboration, they showed that PKG activity stimulates calcium release required for merozoite egress and that this is likely mediated through regulation of phosphoinositide metablism. Since drug resistance is a huge problem, David's group are investigating whether cyclic nucleotide signalling pathways could be targeted in the development of novel antimalarial drugs. 

David received a Wellcome Trust Senior Investigator Award in 2015. This is a joint award with Professor Mike Blackman at the Francis Crick Institute that will focus on the cGMP signalling pathway in malaria parasites.

 

 

Research areas

  • Drug discovery and development
  • Parasites
  • Pharmacokinetics
  • Protozoa

Disciplines

  • Biochemistry
  • Cell biology
  • Genomics
  • Molecular biology
  • Parasitology

Disease and Health Conditions

  • Infectious disease
  • Malaria

Other interests

  • Antiprotozoal Drug Discovery
  • Artemisinin Resistance
  • Cell Signalling
  • Drug Efficacy
  • Epigenetics
  • Gametocytes
  • Gene Expression
  • Infectious Diseases
  • Microbial Pathogenicity
  • Mosquitoes
  • Plasmodium Falciparum Gametocyte Biology
  • Transmission
  • Wellcome Trust
  • cGMP-dependent Protein Kinase
  • cell biology
  • drug development
  • molecualr biology
  • parasites
  • structural biology
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